Early Diagnosis System of Cartilage Degeneration by Ultrasound

超声软骨退变早期诊断系统

基本信息

批准号：
15390457
负责人：
IKEUCHI Ken
金额：
$ 4.03万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

1.Ultrasonic system was established to measure articular cartilage using wavelet transform of reflected wave.2.It is found that strength of reflected wave indicates dynamic stiffness while endurance time indicates damage in the cartilage by simultaneous measurements of dynamic stiffness, density, sound velocity and defects in the cartilage.3.It is found that dynamic stiffness, sound velocity and density reduce with a development of degeneration. Thereafter, endurance time of the reflected wave increases and internal reflection appears.4.It is confirmed by experiment with articular cartilage specimens degenerated by use of collagenase enzyme that maximum strength of the reflected wave decreases with a development of degeneration.5.By means of ultrasonic measurement for unstable rabbit knee model by cutting of ligaments and meniscus and for degenerated cartilage model by collagenase treatment, cartilage at medial femoral chondyle degenerates at first and then degeneration appears at lateral femoral chondyle.6.In addition to the transducer of piezo-electric ceramic, transducer of piezo-electric polymer was produced. Both types were prove applicable to diagnoses of knee joint, hip joint, finger joint and vertebra.7.Cartilage surface of transplanted bone-cartilage complex was measured. It is found that regenerated cartilage after transplantation survives during daily life though its dynamic stiffness is lower than the original cartilage.8.Dynamic stiffness of rabbit knee articular cartilage cultured in vitro was significantly lower than the original cartilage.9.Rabbit knee articular cartilages regenerated by means of several regeneration therapies were measured and compared. According to the result, bone marrows induced to the defect by drilling and chondrocytes injected to scaffold produced cartilage with high dynamic stiffness.

1.建立了使用反射波的小波变换来测量关节软骨的系统。此后，反射波增加的耐力时间增加并出现内部反射。4。通过使用胶原酶使用胶原酶进行了退化来证实，通过使用胶原酶进行了退化，反射波的最大强度会随着变性的发展而通过超声测量的含量和不稳定的模型的培养基培养型ligement andiscement and coterment of ligaMement degerment of Ligamement Menigam Menister and Meniscement of Ligamement and Menist nemist。胶原酶处理，股骨内侧软骨的软骨首先退化，然后在股骨外侧出现变性。6。在压电 - 电陶瓷的换能器外，产生了压电 - 电气聚合物的传感器的换能器。两种类型都适用于诊断膝关节，髋关节，手指关节和椎骨。7。测量了移植的骨 - 肉饼复合物的花序表面。发现在日常生活中移植后的再生软骨生存，尽管其动态刚度低于原始软骨。8。在体外养殖的兔膝盖关节软骨的dynanig僵硬度明显低于原始软骨。9.Rabbit膝盖膝关节膝关节通过了几个Regeneration the the the the and Mealaped and are tealap and are tealap and are Mealape and are tealap and are。根据结果，通过钻孔和软骨细胞注入脚手架的软骨产生的软骨具有高动态刚度，骨髓诱导了缺陷。