Physiological study on the role of zinc enzyme on the improvement of taste disorders

锌酶改善味觉障碍作用的生理研究

基本信息

批准号：
15380087
负责人：
KOMAI Michio
金额：
$ 5.57万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15380087/
关键词：
zinc deficiency taste abnormality rat carbonic anhydrase zinc enzyme lingual trigeminal nerve chorda tympani nerve appetite control peptide 炭酸脱水酵素亜鉛キレート剤三叉神経炭酸脱水酵素(CA)CA II

项目摘要

We have confirmed that NaCl preference is greater in the zinc-deficient and low-zinc rats than in the control (zinc-sufficient and pair-fed) rats after 4 days' feeding. Furthermore, we have also reported that long-term zinc deficiency decreases taste sensitivity at the level of the chorda tympani nerve and that the change in NaCl preference due to zinc deficiency occurs before the decrease in taste sensitivity. In order to clarify the mechanism for the increased NaCl preference observed in zinc-deficient and low-zinc rats at an earlier stage of the feeding, we therefore investigated the effects of zinc deficiency on plasma index (mineral concentration, pH, hematocrit), blood pressure, urinary excretion, water intake and selected hormones. Male 4 week-old Sprague-Dawley rats were divided into three groups (zinc-deficient, low-zinc and pair-fed). At an earlier stage of the feeding period, there was no change of plasma sodium concentration in the zinc-deficient rats. We also investigated that the effects of zinc deficiency on neurohypophysial hormones in rats because brain oxytocin system is important for the regulation of sodium balance via effects on sodium intake and excretion. In consequence, the feeding of zinc-deficient diet causes the decrease of plasma oxytocin concentration even after 4 days' feeding. These results suggest that the dietary signal of zinc-deficiency may reflect NaCl preference, possibly through the hypothalamus-neurohypophysial system.

我们已经证实，在锌和低锌大鼠中，NaCl的偏好比对照4天后的对照（锌充足和配对）大鼠更大。此外，我们还报道说，长期锌缺乏症在鼓膜神经的水平上降低了味觉敏感性，并且在降低味觉敏感性之前，由于锌缺乏症引起的NaCl偏好的变化发生。为了阐明在喂养的早期阶段在锌缺陷率和低锌大鼠中观察到的NaCl偏好的机制，我们研究了锌缺乏对血浆指数（矿物浓度，pH，血液pH，血液pH），血压，尿压排泄，水摄入和选择的激素的影响。雄性4周大的Sprague-Dawley大鼠分为三组（缺乏锌，低锌和配对）。在进食期的较早阶段，缺乏锌的大鼠血浆钠浓度没有变化。我们还研究了锌缺乏对大鼠神经型激素的影响，因为脑催产素系统对于通过对钠摄入和排泄的影响来调节钠平衡很重要。因此，即使在4天后，锌缺陷饮食的喂养也会导致血浆催产素浓度的降低。这些结果表明，锌缺陷的饮食信号可能反映了NaCl的偏好，可能是通过下丘脑 - 非植物学系统。