Physiological study on the role of zinc enzyme on the improvement of taste disorders

锌酶改善味觉障碍作用的生理研究

基本信息

批准号：
15380087
负责人：
KOMAI Michio
金额：
$ 5.57万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15380087/
关键词：
zinc deficiency taste abnormality rat carbonic anhydrase zinc enzyme lingual trigeminal nerve chorda tympani nerve appetite control peptide 炭酸脱水酵素亜鉛キレート剤三叉神経炭酸脱水酵素(CA)CA II

项目摘要

We have confirmed that NaCl preference is greater in the zinc-deficient and low-zinc rats than in the control (zinc-sufficient and pair-fed) rats after 4 days' feeding. Furthermore, we have also reported that long-term zinc deficiency decreases taste sensitivity at the level of the chorda tympani nerve and that the change in NaCl preference due to zinc deficiency occurs before the decrease in taste sensitivity. In order to clarify the mechanism for the increased NaCl preference observed in zinc-deficient and low-zinc rats at an earlier stage of the feeding, we therefore investigated the effects of zinc deficiency on plasma index (mineral concentration, pH, hematocrit), blood pressure, urinary excretion, water intake and selected hormones. Male 4 week-old Sprague-Dawley rats were divided into three groups (zinc-deficient, low-zinc and pair-fed). At an earlier stage of the feeding period, there was no change of plasma sodium concentration in the zinc-deficient rats. We also investigated that the effects of zinc deficiency on neurohypophysial hormones in rats because brain oxytocin system is important for the regulation of sodium balance via effects on sodium intake and excretion. In consequence, the feeding of zinc-deficient diet causes the decrease of plasma oxytocin concentration even after 4 days' feeding. These results suggest that the dietary signal of zinc-deficiency may reflect NaCl preference, possibly through the hypothalamus-neurohypophysial system.

我们已经证实，在喂养 4 天后，缺锌和低锌大鼠的 NaCl 偏好高于对照（锌充足且配对喂养）大鼠。此外，我们还报道，长期缺锌会降低鼓索神经水平的味觉敏感性，并且由于缺锌而导致的氯化钠偏好的变化发生在味觉敏感性降低之前。为了阐明缺锌和低锌大鼠在喂养早期观察到的氯化钠偏好增加的机制，因此我们研究了缺锌对血浆指数（矿物质浓度、pH、血细胞比容）、血细胞比容的影响。压力、尿液排泄、饮水量和选定的激素。将 4 周龄雄性 Sprague-Dawley 大鼠分为三组（缺锌组、低锌组和配对喂养组）。在喂养初期，缺锌大鼠的血浆钠浓度没有变化。我们还研究了缺锌对大鼠神经垂体激素的影响，因为脑催产素系统通过影响钠的摄入和排泄来调节钠平衡。因此，即使饲喂4天后，饲喂缺锌饲料仍会导致血浆催产素浓度下降。这些结果表明，缺锌的饮食信号可能反映了对氯化钠的偏好，可能是通过下丘脑-神经垂体系统。