Construction of physiological, hematological and biochemical databases for the "Lifespan Prediction Model"

“寿命预测模型”生理、血液、生化数据库构建

基本信息

批准号：
15300230
负责人：
TANAKA Kiyoji
金额：
$ 10.24万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15300230/
关键词：
vitality age database older adults physiological age ageing activities of daily living exercise habituation quality of life

项目摘要

The purposes of this study were 1)to examine the relationship between lifespan and physical vitality (vital age) based on physiological, hematological and biochemical cross-sectional data, and 2)to evaluate the validity of estimating lifespan using the <Lifespan Prediction Model> by comparing middle-aged and older adults with lower physical vitality to those with higher physical vitality. Physical vitality was based on a combination of health/fitness information for anemia, serum cholesterol level, agility and aerobic work capacity. Participants in this study were 232 Japanese people (78 men and 157 women, aged 27-91 years) who underwent the physical vitality assessment. During the follow-up study period from 1991 to 2005,twelve people (9 men and 3 women) died. This study attempted to test the hypothesis that lifespan can be predicted from the difference between chronological age and vital age (based on physical vitality scores).The following results were obtained : 1.Patients with cardiovascular disease and diabetes mellitus who died during the follow-up period had relatively lower physical vitality as evidenced by anemia, lower HDLC, and lower physical fitness level at baseline. 2.Vital age for regularlyexercising coronary patients was significantly younger than patients who stopped exercising.These results indicate that exercise habituation for an extended period of time (5 years or more) favorably affects the physical vitality of coronary patients, supporting a model of lifespan prediction using physical vitality consisting of anemia, serum cholesterol level, agility and oxygen uptake.

本研究的目的是1）根据生理、血液和生化横截面数据检查寿命和身体活力（生命年龄）之间的关系，2）评估使用<寿命预测模型>估计寿命的有效性将身体活力较低的中老年人与身体活力较高的中老年人进行比较。身体活力基于贫血、血清胆固醇水平、敏捷性和有氧工作能力等健康/健身信息的组合。这项研究的参与者是 232 名日本人（78 名男性和 157 名女性，年龄 27 岁至 91 岁），他们接受了身体活力评估。在1991年至2005年的跟踪研究期间，有12人（9男3女）死亡。本研究试图检验这样的假设：根据实足年龄和生命年龄（基于身体活力评分）之间的差异可以预测寿命。获得以下结果： 1.在接下来的时间里死亡的患有心血管疾病和糖尿病的患者上升期的身体活力相对较低，表现为贫血、低密度脂蛋白胆固醇 (HDLC) 和基线体能水平较低。 2.定期运动的冠心病患者的生命年龄明显比停止运动的患者年轻。这些结果表明，长时间（5年或更长）的运动习惯有利于冠心病患者的身体活力，支持寿命预测模型使用由贫血、血清胆固醇水平、敏捷性和摄氧量组成的身体活力。