Construction of physiological, hematological and biochemical databases for the "Lifespan Prediction Model"

“寿命预测模型”生理、血液、生化数据库构建

• 批准号: 15300230
• 负责人: TANAKA Kiyoji
• 金额: $ 10.24万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15300230/
• 关键词: vitality age; database; older adults; physiological age; ageing; activities of daily living; exercise habituation; quality of life; vitality age; database; older adults; physiological age; ageing; activities of daily living; exercise habituation; quality of life

The purposes of this study were 1)to examine the relationship between lifespan and physical vitality (vital age) based on physiological, hematological and biochemical cross-sectional data, and 2)to evaluate the validity of estimating lifespan using the <Lifespan Prediction Model> by comparing middle-aged and older adults with lower physical vitality to those with higher physical vitality. Physical vitality was based on a combination of health/fitness information for anemia, serum cholesterol level, agility and aerobic work capacity. Participants in this study were 232 Japanese people (78 men and 157 women, aged 27-91 years) who underwent the physical vitality assessment. During the follow-up study period from 1991 to 2005,twelve people (9 men and 3 women) died. This study attempted to test the hypothesis that lifespan can be predicted from the difference between chronological age and vital age (based on physical vitality scores).The following results were obtained : 1.Patients with cardiovascular disease and diabetes mellitus who died during the follow-up period had relatively lower physical vitality as evidenced by anemia, lower HDLC, and lower physical fitness level at baseline. 2.Vital age for regularlyexercising coronary patients was significantly younger than patients who stopped exercising.These results indicate that exercise habituation for an extended period of time (5 years or more) favorably affects the physical vitality of coronary patients, supporting a model of lifespan prediction using physical vitality consisting of anemia, serum cholesterol level, agility and oxygen uptake.

这项研究的目的是1）研究基于生理，血液学和生化横截面数据的生命周期与身体活力（生命年龄）之间的关系，以及2）），使用<寿命预测模型>通过比较具有较低物理活力的老年人的寿命预测模型>估计寿命的有效性。身体活力基于贫血，血清胆固醇水平，敏捷性和有氧工作能力的健康/健身信息的结合。这项研究的参与者有232名日本人（78名男性和157名27-91岁的女性）接受了身体活力评估。在1991年至2005年的后续研究期间，十二人（9名男性和3名妇女）死亡。这项研究试图检验以下假设：生命周期可以从年龄和生命年龄之间的差异（基于身体活力评分）之间的差异。获得以下结果：1。患有心血管疾病和糖尿病的患者在随访期间死亡的糖尿病和糖尿病的身体较低的身体具有较低的身体，而身体较低的身体状况较低，较低的身体状况较低，基础较低，基础较低，基本水平较低。 2.定期进行冠状动脉患者的重要年龄要比停止运动的患者年轻。这些结果表明，长期（5年或更长时间）的运动习惯对冠状动脉患者的身体活力产生了有益的影响，从而支持了使用贫血，血清胆固醇水平，脂肪，氧化和氧化物的寿命预测模型。