Transillumination imaging of biological body using snake photons

使用蛇光子对生物体进行透射成像

• 批准号: 15300149
• 负责人: SHIMIZU Koichi
• 金额: $ 10.05万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15300149/
• 关键词: snake photon; near-axis scattered light; near-infrared light; scattering; transillumination imaging; optical CT; light diffusion; time-resolved measurement

For transillumination imaging of a biological body by near-infrared light, a technique has been developed to realize the imaging of absorption distribution in diffuse scattering medium. Through this study, the following results were obtained.(1)In theoretical and experimental analyses, it was verified that a detectable amount of snake photons is emitted through the dense medium which could not see through with the conventional technique using ballistic photons.(2)A technique has been developed to detect the snake photon efficiently through the scattering object which corresponds to the mammalian tissue with 10-20 mm thickness. This technique is based on the time-resolved measurement of output pulse shape for ultra-fast light-pulse incidence.(3)A new technique has been developed to apply the above principle to the much simpler continuous wave (CW) measurement using a CW light source.(4)An experimental system was newly developed which consisted of a snake-photon detection device, a model phantom to simulate the optical property of mammalian tissue and an imaging system.(5)The effectiveness of the proposed principle and the usefulness of the developed system were verified in the imaging experiment using the above experimental system.(6)The proposed principle and the developed system were applied to the transcutaneous fluorescent imaging.(7)An analytical solution was obtained to describe the photon propagation in a dense random medium by applying the diffusion approximation to the equation of transfer. Using this solution, a technique to improve the transillumination image through a diffusing medium was newly developed.(8)Through this study, a concrete measure was obtained to realize the transillumination imaging using snake photons as well as clarifying the problems to be solved.

对于生物体的近红外光透照成像，已经开发了一种技术来实现漫散射介质中吸收分布的成像。通过这项研究，获得了以下结果：（1）在理论和实验分析中，验证了通过使用弹道光子的传统技术无法穿透的致密介质发射了可检测量的蛇光子。（2 ）已经开发出一种技术，可以通过相当于厚度为10-20毫米的哺乳动物组织的散射物体来有效地检测蛇光子。该技术基于超快光脉冲入射的输出脉冲形状的时间分辨测量。(3) 已开发出一种新技术，可将上述原理应用于使用 CW 的更简单的连续波 (CW) 测量(4)新开发了一种实验系统，由蛇光子探测装置、模拟哺乳动物组织光学特性的模型体模和成像系统组成。(5)该原理的有效性和实用性所开发系统的验证(6)将所提出的原理和开发的系统应用于经皮荧光成像。(7)应用扩散近似获得了描述光子在致密随机介质中传播的解析解到转移方程。利用该解决方案，新开发了一种通过扩散介质改善透照成像的技术。(8)通过本研究，获得了利用蛇光子实现透照成像的具体措施，并明确了需要解决的问题。

项目成果

CW detection of near-axis scattered light for transillumination imaging

用于透射成像的近轴散射光的连续波检测

• 发表时间: 2006
• 期刊: Proceedings of OSA topical meeting on Biomedical Optics CD-ROM
• 作者: K.Takagi;et al.
• 通讯作者: et al.

Derivation of PSF from diffusion equation for transcutaneous fluorescent imaging

从经皮荧光成像的扩散方程推导 PSF

• 发表时间: 2004
• 期刊: Proceedings of 2^<nd> Asian and Pacific Rim Symposium on Biophotonics
• 作者: Koichi Shimizu;et al.
• 通讯作者: et al.

Applied optical technology for medicine (Koichi Shimizu, ed.)

医学应用光学技术（清水浩一主编）

• 发表时间: 2004
• 作者: S.Kuriki;N.Watanabe;F.Takeuchi;H.Hagiwara;T.Soshi;A.Kouso;何 小明;Koichi Shimizu
• 通讯作者: Koichi Shimizu

Advanced Information in the field of Near Infrared Spectroscopy

近红外光谱领域的高级信息

• 发表时间: 2003
• 作者: Masataka Kitama;et al.
• 通讯作者: et al.

Koichi Shimizu, et al.: "Improvement of transcutaneous fluorescent image by depth-dependent PSF"Technical Digest of OSA Biomedical Topical Meetings. (in press). (2004)

Koichi Shimizu 等人：“通过深度相关 PSF 改进经皮荧光图像”OSA 生物医学专题会议技术文摘。