Development of Benign Chemical Processes on Nano-seized Reaction Environments

纳米反应环境下良性化学工艺的发展

基本信息

批准号：
14207095
负责人：
KOBAYASHI Shu
金额：
$ 31.78万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

Development of highly efficient chemical processes with no harmful waste is an important subject from an environmental viewpoint. In our project, development of organic reactions in water and development of polymer-immobilized catalysts have been focused. The results obtained are summarized below.1.Organic reaction in water is one of the most promising methods in environmental benign chemical processes. Furthermore, water sometimes plays an interesting role on reactivity and selectivity of organic reactions. We carried out investigations of organic reactions in water, and it was found that a Brφnsted acid-surfactant combined catalyst worked as a good reaction promoter in dehydrating reactions in water by forming hydrophobic reaction environments. We also showed that polymer supported Brφnsted acid is effective in several reactions in water ; for example, dehydrating reactions, deprotecting reactions of alcohols, etc. Moreover, highly enantioselective Mannich-type reactions and hydroxymethylation in aqueous media were also achieved. Those results would inspire that water is a promising solvent.2.Highly functionalized organometallic catalysts were sometimes harmful to human body and environment. Therefore, it is important to develop chemical processes without any organometallic waste. Our group has already developed microencapsulate methods for immobilizing metal-containing catalysts. In this project, we focused immobilization of useful metal-containing catalysts, ruthenium, palladium and osmium compounds. Those reagents were successfully immobilized on novel polymers with perfect recovery and reuse. Those catalysts were also employed in metathesis, hydrogenation, and asymmetric dihydroxylation of olefins with high efficiency. The results obtained would contribute to development of clean chemical processes.

从环境角度来看，开发无有害废物的高效化学工艺是一个重要课题，我们的项目重点关注水中有机反应的发展和聚合物固定化催化剂的开发。1.有机。水中反应是环境友好的化学过程中最有前途的方法之一，此外，我们在水中进行有机反应，发现水有时起着有趣的作用。我们还表明，聚合物负载的布朗斯台德酸在水中的脱水反应、醇的脱保护反应等中是有效的。此外，在水介质中还实现了高度对映选择性的曼尼希型反应和羟甲基化反应，这些结果表明水是一种有前途的溶剂。2.高功能化的有机金属催化剂有时是有害的。因此，开发不产生任何有机金属废物的化学方法非常重要，在这个项目中，我们重点关注有用的含金属催化剂的固定化。这些试剂成功地固定在新型聚合物上，并具有完美的回收和再利用催化剂，这些试剂也可用于复分解、氢化和不对称二羟基化。所获得的结果将有助于清洁化学工艺的发展。