DEVELOPMENT OF THERMOACOUSTIC FREEZING TECHNIQUE FOR LIVER CANSER

肝癌热声冷冻技术的开发

• 批准号: 13680942
• 负责人: TAKAHASHI Manabu
• 金额: $ 2.24万
• 依托单位: EHIME UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680942/
• 关键词: LIVER CANSER; LOCAL FREEZING; THERMO ACAUSTIC COOLING; NEEDLE FOR COOLING; EXCISION RESISTANCE; TEMPERATURE FOR EXCISION; PARTIAL FREEZING; COOLING VELOSITY

To excise a cancer along a free-designed resection curve, the formulation of the cooling phenomenon was conducted through the experiments using a liver of a pig. The physical properties were estimated by the reverse-analysis using the finite element method based on the heat transfer characteristic data of a liver. In addition, the proposed equation can express the relation among arbitrary cooling time and distance and temperature.Isolation of the liver was conducted using a scalpel attached to the end-effector of a three-axes vertical revolute robot. Excision force showed minimum at a liver freezing temperature of 1.5 to - 2.0℃ in the experiments ; therefore, it is preferable that the liver be excised in this temperature range. By changing cooling velocity, the excision force becomes reduced when the cooling velocity is small even if the temperature of the liver remains the same. The lower the temperature of the liver is, the larger the increment rate of excision force is with regard t … More o cooling velocity.The cooling experiment by thermo acoustic freezing in a brass tube was investigated experimentally. This thermo acoustic apparatus is composed of a brass tube used as the acoustic resonant tube and "stuck" inserted to this tube. The brass tube has 2 mm thick, with a inner diameter of 26 mm and a length of 1500 mm, which is equal to about 1/4 wavelengths. The stuck was made by bundling 100 tubes insulating tubes with an inner diameter of 1mm. A standard audio speaker adopted as the acoustic driver. The cooling experiment was carried out under the normal temperature normal pressure. The air and the helium gas were used as the working fluid. The temperature difference at both ends of the stack in the helium gas was three times larger than that in the air. The stack surface area, the internal local pressure, and the pressure amplitude of the speaker have a dominant role on the cooling capacity. It is possible to freeze the hepatocyte of about 1mm3 by using the present conventional (or simple) refrigeration system. Less

为了沿着自由设计的切除曲线切除癌症，通过使用猪肝脏的实验来制定冷却现象，并使用基于传热的有限元方法进行逆向分析来估计物理特性。此外，所提出的方程可以表达任意冷却时间与距离和温度之间的关系，这是使用连接到三轴垂直旋转切除机器人末端执行器的手术刀进行的。力显示最小值实验中肝脏冷冻温度为1.5℃至-2.0℃；因此，优选在该温度范围内切除肝脏，通过改变冷却速度，即使冷却速度较小，切除力也会减小。肝脏温度越低，切除力相对于冷却速度的增量越大。通过实验研究了在黄铜管中进行热声冷冻的冷却实验。声学装置由以下组成插入一根黄铜管作为声学谐振管并“粘”在该管上。该黄铜管厚 2 毫米，内径 26 毫米，长度 1500 毫米，大约等于 1/4 波长。将100根内径为1mm的绝缘管捆扎而成，采用标准音频扬声器作为声学驱动器，在常温常压下进行。采用氦气作为工作流体，氦气中电堆两端的温差是空气中的三倍，电堆表面积、内部局部压力以及扬声器的压力幅值都有所不同。使用现有的常规（或简单）制冷系统可以冷冻约1mm3的肝细胞。