Analysis of the effects of motor command for vocalization upon auditory mechanisms in the brainstem

发声运动指令对脑干听觉机制的影响分析

• 批准号: 13671762
• 负责人: SAKAMOTO Takashi
• 金额: $ 2.3万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671762/
• 关键词: Vocalization; Periaqueductal gray; Auditory relay neuron

To investigate the effects of motor commands for vocalization upon auditory mechanisms in the brainstem during actual vocalization movement, we first identified the auditory relay neurons within the brainstem, and analyzed the inputs from the vocalization center and their discharge properties.In precollicular-postmammilary decerebrate cats, we employed the midbrain periaqueductal gray as the vocalization center, and analyzed the discharge properties of auditory relay neurons within the dorsal and ventral nuclei of the lateral remuniscus responding to the auditory stimuli that has the same fundamental frequency and formant as those of induced vocalization. These stimuli were reconstructed by the computer controlled apparatus that was equipped by this grant.We first tried to identify the responsibility to the single electrical shock delivered to the vocalization center and the responsibility to the different auditory stimuli, and then the discharge properties of these neurons during the actual vocalization movements.Most of recorded auditory relay neurons did not respond to the single shock delivered to the vocalization center within the stimulus strength which could induce vocalization movements. With higher stimulus strength, some neurons received suppressive effects and some were excitatory. However, these differences were not significant statistically, so that we did not published our results yet. To clarify the effects from the vocalization center, we are now trying to analyze the effects upon the discharges induced by the auditory stimuli. The analysis of discharge properties of auditory relay neurons during actual vocalization was not performed yet, because accompanying movements of brainstem was unexpectedly large so that stable recording was quite difficult.

为了研究实际发声运动过程中发声运动命令对脑干听觉机制的影响，我们首先识别了脑干内的听觉中继神经元，并分析了发声中枢的输入及其放电特性。 ，我们以中脑导水管周围灰质为发声中枢，分析了侧联神经背侧核和腹侧核内听觉中继神经元的放电特性与诱发发声具有相同基频和共振峰的听觉刺激。这些刺激是由该拨款配备的计算机控制设备重建的。我们首先尝试确定对发声中心的单次电击的责任和对不同听觉刺激的责任，然后确定这些神经元的放电特性大多数记录的听觉中继神经元对在可引起发声运动的刺激强度内传递到发声中枢的单次冲击没有反应。当刺激强度较高时，一些神经元受到抑制作用，而另一些神经元则受到兴奋​​作用。然而，这些差异在统计上并不显着，因此我们尚未发表我们的结果。为了阐明发声中枢的影响，我们现在尝试分析对听觉刺激引起的放电的影响。尚未对实际发声过程中听觉中继神经元的放电特性进行分析，因为伴随的脑干运动出乎意料地大，因此稳定记录相当困难。