Basic and clinical investigations on fetal blood pressure monitoring in labor by the difference in electrocardiogram and pulse oxymetry.

心电图和脉搏血氧饱和度差异监测临产胎儿血压的基础和临床研究。

• 批准号: 13671734
• 负责人: SAMESHIMA Hiroshi
• 金额: $ 2.3万
• 依托单位: (Miyazaki Medical College) University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671734/
• 关键词: Blood pressure; Electromechanical difference; Fetus; Pulse oxymetry; Plethysmograph; Labor and delivery; 胎児心拍数モニタリング; electro-mechanical delay time; 酸素飽和度モニター

In animal experiments using chronically instrumented fetal goat, we decreased fetal blood pressure by about 10 mmHg by administrating hypotensive agents or by withdrawing some amount of fetal blood. We measured intravascular blood pressure (actual-BP), heart rate, pulse oxymeter waveforms of the fetuses continuously. The time difference in electrocardiogram (the peak R-wave) and pulse oxymetry (the maximum increase in slope) was used to estimate the blood pressure (estmate-BP) with a predetermined equation "HASTE" A significant correlation (p<0.01) with good bias values (<8mmHg) and precision values (<5 mmHg) was obtained between the actual-BP and estimate-BP in all animals. This technique has the potential to provide information on fetal blood pressure on a beat-by-beat basis, which will aid in the interpretation of fetal heart rate monitoring in labor and delivery.

在使用长期仪器仪表的胎山羊进行的动物实验中，我们通过给予降压药或抽取一定量的胎儿血液，将胎儿血压降低了约10毫米汞柱。我们连续测量胎儿的血管内血压（实际血压）、心率、脉搏血氧仪波形。心电图（峰值 R 波）和脉搏血氧饱和度（斜率最大增加）的时间差用于通过预定方程“HASTE”估计血压（估计-BP），与所有动物的实际血压和估计血压之间都获得了良好的偏差值（<8mmHg）和精度值（<5mmHg）。该技术有可能提供逐次心跳的胎儿血压信息，这将有助于解释临产和分娩过程中的胎儿心率监测。

项目成果

Sameshima H, Ikenoue T, Ikeda T, Kamitomo M, Ibara S: "Unselected low risk pregnancies and continuous intrapartum fetal heart rate monitoring blood gases and cerebral palsy"Am J Obstet Gynecol. 190. 118-123 (2004)

Sameshima H、Ikenoue T、Ikeda T、Kamitomo M、Ibara S：“未选择的低风险妊娠和连续产时胎心率监测血气和脑瘫”Am J Obstet Gynecol。

鮫島浩: "胎児の病態生理学的変化に基づく分娩時心拍数モニタリングの再評価"日本産科婦人科学会誌. 54(8). 1103-1115 (2002)

Hiroshi Samejima：“基于胎儿病理生理变化的产时心率监测的重新评估”日本妇产科学会杂志 54（8）1103-1115（2002）。

Xia XY, Sameshima H, Ikeda T, Higo T, Ikenoue T: "Cerebral blood flow distribution and hypoxic-ischemic brain damage in newborn rats"J Obstet Gynecol Res. 28. 320-326 (2002)

Xia XY，Sameshima H，Ikeda T，Higo T，Ikenoue T：“新生大鼠的脑血流分布和缺氧缺血性脑损伤”J Obstet Gynecol Res。

Sameshima H, Ikenoue T, Ikeda T, Kamitomo M, Ibara S: "Unselected low risk pregnancies and continuous intrapartum fetal heart rate monitoring on umbilical blood gases and cerebral palsy"Am J Obstet Gynecol. 190. 118-123 (2004)

Sameshima H、Ikenoue T、Ikeda T、Kamitomo M、Ibara S：“未经选择的低风险妊娠和连续产时胎心率监测对脐血气体和脑瘫的影响”Am J Obstet Gynecol。

Sameshima H, Kawagoe Y, Ikenoue T, Sakamoto H: "Continous systolic blood pressure monitoring by the difference in electrocardiogram and pulse oximetry in the near term, exteriorized goat fetuses."J Soc Gynecol Invest. 10. 200-204 (2003)

Sameshima H、Kawagoe Y、Ikenoue T、Sakamoto H：“近期通过心电图和脉搏血氧饱和度的差异进行连续收缩压监测，外化山羊胎儿。”J Soc Gynecol Invest。