Relationship between the changes of endocrine systems and prognosis in patients with cancer

癌症患者内分泌系统变化与预后的关系

• 批准号: 13671321
• 负责人: RINO Yasushi
• 金额: $ 2.24万
• 依托单位: yokohama city university
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671321/
• 关键词: gastric cancer; growth hormone; paradoxical response; thyrotropin releasing hormone; TRH負荷テスト; 成長ホルモンの奇異反応; 担癌; 進行胃癌; 予後; 内分泌環境; 食道癌; 担癌生体; 全身状態

Background : Patients with gastric cancer have been noted to have an abnormal response to thyrotropin releasing hormone (TRH) of growth hormone (GH). The abnormal response is called GH paradoxical response (PR). We estimated the correlation between endocrine abnormalities and prognosis of the patients with gastric cancer. Methods : Subjects were 101 patients with gastric cancer, 40 Stage I, 8 Stage II, 26 Stage III, 27 Stage IV. Stage I patients consisted of 29 males and 11 females. Stage II patients consisted of 5 males and 4 females. Stage III patients consisted of 23 males and 3 females. Stage IV patients consisted of 17 males and 10 females. None of the patients had a history of endocrine diseases. Serum GH and serum TSH levels were measured by radioimmunoassay before and after a single shot of 500 micrograms of TRH. PR were evaluated all patients. Collu et al reported that PR is defined by an increase to at least twice the baseline levels and greater than 5ng/ml. Survival rates were compared between PR positive and negative groups. Results : PR was observed 10 out of 40 cases in Stage I, and 12 out of 27 cases in Stage IV. PR positive rate was not significantly higher in Stage IV than Stage I patients. Whereas there are two patterns of PR. One is a rapid response after TRH administration (rapid response type) and the other is a late response (late response type). Positive PR group had no significant poor prognosis. However, prognosis of gastric cancer patients was better in PR negative group and late response type of PR than rapid response type of PR positive group. There was significant difference that p-value was 0.0002. Conclusions: PR of GH may be a good prognostic indicator in gastric cancer patients.

背景：胃癌患者已注意到生长激素（GH）对甲状腺激素释放激素（TRH）的反应异常。异常反应称为GH悖论反应（PR）。我们估计内分泌异常与胃癌患者预后之间的相关性。方法：受试者是101例胃癌患者，40阶段I，第8阶段II，26阶段III，第27阶段IV。 I期患者由29名男性和11名女性组成。 II期患者由5名男性和4名女性组成。 III期患者由23名男性和3名女性组成。 IV期患者由17名男性和10名女性组成。没有患者患有内分泌疾病史。在500微克TRH的单次拍摄之前和之后，通过放射免疫测定法测量血清GH和血清TSH水平。 PR评估了所有患者。 Collu等人报道，PR的定义是基线水平至少增加了两倍，大于5ng/ml。比较PR阳性和负基组之间的存活率。结果：在I期中，有40例中有10例，在第四阶段的27例中有12例。在IV期中，PR阳性率没有明显高于I期患者。而PR有两种模式。一种是TRH给药后的快速响应（快速响应类型），另一种是较晚响应（晚期响应类型）。阳性PR组没有明显的预后不良。然而，与PR阳性组的快速反应类型相比，PR阴性组和PR的较晚反应类型的胃癌患者的预后更好。 p值为0.0002是有显着差异的。结论：GH的PR可能是胃癌患者的良好预后指标。