Relationship between the changes of endocrine systems and prognosis in patients with cancer

癌症患者内分泌系统变化与预后的关系

• 批准号: 13671321
• 负责人: RINO Yasushi
• 金额: $ 2.24万
• 依托单位: yokohama city university
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671321/
• 关键词: gastric cancer; growth hormone; paradoxical response; thyrotropin releasing hormone; TRH負荷テスト; 成長ホルモンの奇異反応; 担癌; 進行胃癌; 予後; 内分泌環境; 食道癌; 担癌生体; 全身状態

Background : Patients with gastric cancer have been noted to have an abnormal response to thyrotropin releasing hormone (TRH) of growth hormone (GH). The abnormal response is called GH paradoxical response (PR). We estimated the correlation between endocrine abnormalities and prognosis of the patients with gastric cancer. Methods : Subjects were 101 patients with gastric cancer, 40 Stage I, 8 Stage II, 26 Stage III, 27 Stage IV. Stage I patients consisted of 29 males and 11 females. Stage II patients consisted of 5 males and 4 females. Stage III patients consisted of 23 males and 3 females. Stage IV patients consisted of 17 males and 10 females. None of the patients had a history of endocrine diseases. Serum GH and serum TSH levels were measured by radioimmunoassay before and after a single shot of 500 micrograms of TRH. PR were evaluated all patients. Collu et al reported that PR is defined by an increase to at least twice the baseline levels and greater than 5ng/ml. Survival rates were compared between PR positive and negative groups. Results : PR was observed 10 out of 40 cases in Stage I, and 12 out of 27 cases in Stage IV. PR positive rate was not significantly higher in Stage IV than Stage I patients. Whereas there are two patterns of PR. One is a rapid response after TRH administration (rapid response type) and the other is a late response (late response type). Positive PR group had no significant poor prognosis. However, prognosis of gastric cancer patients was better in PR negative group and late response type of PR than rapid response type of PR positive group. There was significant difference that p-value was 0.0002. Conclusions: PR of GH may be a good prognostic indicator in gastric cancer patients.

背景：已注意到胃癌患者对生长激素（GH）的促甲状腺素释放激素（TRH）有异常反应。这种异常反应称为 GH 矛盾反应 (PR)。我们评估了胃癌患者内分泌异常与预后之间的相关性。方法：受试者为 101 例胃癌患者，其中 I 期 40 例，II 期 8 例，III 期 26 例，IV 期 27 例。 I 期患者包括 29 名男性和 11 名女性。 II期患者包括5名男性和4名女性。 III期患者包括23名男性和3名女性。 IV期患者包括17名男性和10名女性。所有患者均无内分泌疾病史。在单次注射 500 微克 TRH 之前和之后，通过放射免疫测定法测量血清 GH 和血清 TSH 水平。对所有患者进行 PR 评估。 Collu 等人报道，PR 的定义是增加至基线水平至少两倍且大于 5ng/ml。比较 PR 阳性组和阴性组的生存率。结果：I期40例中有10例PR，IV期27例中有12例PR。 IV期患者的PR阳性率并不显着高于I期患者。而公关有两种模式。一种是TRH给药后快速反应（快速反应型），另一种是迟发反应（晚期反应型）。 PR阳性组无明显不良预后。但PR阴性组和PR晚期缓解型胃癌患者的预后优于PR阳性快速缓解型组。存在显着性差异，p 值为 0.0002。结论：GH PR可能是胃癌患者良好的预后指标。