Development of a new type proton irradiation system built in a rotating gantry

新型旋转龙门质子辐照系统的开发

• 批准号: 13670914
• 负责人: MARUHASHI Akira
• 金额: $ 2.18万
• 依托单位: KYOTO UNIVERSITY (2002-2003)University of Tsukuba (2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670914/
• 关键词: Proton Therapy; Energy Filter; SOBP; Opposing Pair Field; Intensity Modulation; Bolus; Collimator; Integrity of Cell Division; 陽子線; 回転ガントリー; 拡大ブラッグピーク; 低融点合金; 線量分布; SOBP(拡大ブラッグピーク); MLC(マルチリックシリメータ); 回転ガントリ; MLC(マルチリーフコリメータ); 可変形状ボーラス

The object of this study is to propose a new type of an irradiation system for the proton cancer therapy. This system is developed to make good use of the rotating gantry system which is suitable to select various rotating angles of axis of opposing pair field. This study has main two subjects to improve the present state of the art of the proton cancer therapy to make it use for any person who will hope it.The fist is to develop a more compact, smaller, simpler and cheaper system to make the intensity distribution of a typical beam extracted from an accelerator as a penciliform beam with narrow Bragg-peak modify to uniformly irradiate the extended width of the target volume to the highest dose. As a result of this research, we proposed a new energy filter which plays both roles of a scattering system for transverse spreading of proton beam and of a bar ridge filter for modulating the range of the Bragg curve.The second is to develop a simple irradiation method to improve the conformity of the highest dose region of 3-D dose distribution of the proton beam to the target region. As a result, it was clearly shown that it is important to make positively use of non-uniformity of a transverse profile and of an axial profile within a spread of Bragg-peak of a 3-D dose distribution.

本研究的目的是提出一种用于质子癌症治疗的新型照射系统。该系统的开发是为了充分利用旋转龙门系统，适合选择相对对场轴的各种旋转角度。这项研究主要有两个主题，以提高质子癌症治疗的现有技术水平，使其适用于任何希望它的人。第一个是开发一种更紧凑、更小、更简单和更便宜的系统，以提高质子癌症治疗的强度。从加速器提取的典型光束的分布为具有窄布拉格峰的铅笔形光束，修改以均匀地照射目标体积的扩展宽度至最高剂量。作为这项研究的结果，我们提出了一种新的能量滤波器，它既起到质子束横向扩展的散射系统的作用，又起到调节布拉格曲线范围的条脊滤波器的作用。提高质子束3D剂量分布的最高剂量区域与目标区域的一致性的方法。结果，清楚地表明，积极利用3D剂量分布的布拉格峰的扩展内的横向轮廓和轴向轮廓的不均匀性是重要的。

项目成果

野口実穂: "標的領域に付与される陽子線の線量分布の最適化に関する研究"医学物理. 22(Sup.2). 75-76 (2002)

Miho Noguchi：“应用于目标区域的质子束剂量分布的优化研究”医学物理22（Sup.2）（2002）。

Y.Takada, A.Maruhashi, T.Sakae, K.Yasuoka, A.Nohtomi: "Commissioning for new proton therapy facility (#1)"Japanese Journal of Medical physics. 21 (sup.2). 144-145 (2001)

Y.Takada、A.Maruhashi、T.Sakae、K.Yasuoka、A.Nohtomi：“新质子治疗设施的调试（

A.Maruhashi: "Experimental in vitro proton RBE (relative to ^<137>Cs-γ) at PMRC"Abstracts of the XXXV PTCOG Meeting. 9 (2001)

A.Maruhashi：“PMRC 的体外质子 RBE（相对于^<137>Cs-γ）”摘要 XXXV PTCOG 9 (2001)。

安岡 聖: "陽子線線量分布測定における検出器依存性"医学物理. 21(Sup.2). 131-132 (2001)

Hijiri Yasuoka：“质子剂量分布测量中的探测器依赖性”医学物理学 21（Sup.2）。

K.Yasuoka, Y.Takada, A.Maruhashi, T.Sakae, A.Nohtomi: "Detector dependency of the dose distribution of proton beams"Japanese Journal of Medical physics. 21 (sup.2). 131-132 (2001)

K.Yasuoka，Y.Takada，A.Maruhashi，T.Sakae，A.Nohtomi：“质子束剂量分布的探测器依赖性”日本医学物理学杂志。