Effect of estrogen on cardiovascular responses to psychological stress in rats

雌激素对大鼠心理应激心血管反应的影响

• 批准号: 13670064
• 负责人: MORIMOTO Keiko
• 金额: $ 2.3万
• 依托单位: Nara Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670064/
• 关键词: psychological stress; estrogen; blood pressure; Corticotrophin releasing hormone (CRH); plasma norepinephrine; plasma epinephrine; telemetry system; heart rate; Corticotrophin releasing hormone(CRH); 脳室内投与; α-helical CRH; エストロゲン補充; 性差; 循環反応

Estrogens are reported to have cardiovascular protective effects, but the mechanisms underlying these effects are not well defined. We investigated the sex difference in stress-induced cardiovascular responses and the effect of estrogen on these responses in free-moving adult rats. Furthermore, we assessed the central role of estrogen on the effect of corticotrophin-releasing hormone (CRH) in stress-induced cardiovascular responses.Four groups of rats, which consisted of male (M), normal female (NF), ovariectomized+placebo-treated (P) and ovariectomized+estrogen-treated (E) groups, were used in this experiment.1. Psychological stress was induced by cage-switch stress. After rats were placed in the novel environment, blood pressure and heart rate significantly increased. Blood pressure elevation was attenuated significantly in the NF group compared with the M group. Ovariectomy diminished the sex difference of blood pressure response to the stress.2. In the M group blood pressure elevat … More ion during cage-switch stress, which was repeated 60 min daily, was weakened on the 2nd and the 3rd days compared with the 1st day, but not in the NF group.2. The blood pressure responses were suppressed significantly in the E group compared with the P group during cage-switch and restraint stress. The plasma norepinephrine response induced by cage-switch stress was attenuated significantly in the E group.3. In unstressed NF, P and E group rats, the intracerebroventricular (I.C.V.) injection of CRF-41 (10 μg) increased blood pressure and heart rate. However, there were no significant differences between 3 groups.4. The I.C.V.injection of a-helical CRH (9-41), a CRH-41 receptor antagonist, did not attenuated the stress-induced hypertension in the 3 groups of female rats.These results suggest that estrogen may influence blood pressure regulation during stress in suppressing the activation of a sympathetic nervous tone in female rat. The mechanisms responsible for the greater resistance to these stresses in the NF and E group should be investigated further. Less

据报道，雌激素具有心血管保护作用，但是这些作用的基础机制尚未很好地定义。我们研究了压力诱导的心血管反应的性别差异以及雌激素对自由移动的成年大鼠这些反应的影响。 Furthermore, we assessed the central role of estrogen on the effect of corticotrophin-releasing horseone (CRH) in stress-induced cardiovascular responses.Four groups of rats, which consisted of male (M), normal female (NF), ovariectomized+placebo-treated (P) and ovariectomized+estrogen-treated (E) groups, were used in this实验1。心理压力是由笼子开关压力引起的。将大鼠放置在新的环境中后，血压和心率显着增加。与M组相比，NF组的血压升高显着衰减。卵巢切除术减少了对应激的血压反应的性别差异2。在M组血压升高中……每天重复60分钟的笼子开关应力的离子在第二天和第3天相比在第2天和第三天减弱，但在NF组中不相比2。在笼子开关和约束应力期间，与P组相比，E组的血压反应被显着抑制。 E组在CAGE开关应激诱导的血浆去甲肾上腺素反应显着衰减3。在无数NF，P和E组大鼠中，脑室内（I.C.V.）注射CRF-41（10μg）的血压和心率会增加。但是，3组之间没有显着差异。4。 I.C.V. A螺旋CRH（9-41）是CRH-41受体拮抗剂，并未减弱3组女性大鼠的应激诱导的高血压。这些结果表明，这些结果表明，在抑制女性大鼠同情性抑制性抑制同情性抑制的雌激素时，雌激素可能会影响血压调节。应进一步研究导致NF和E组中对这些应力更大抗性的机制。较少的

项目成果

Keiko Morimoto, Yoko Kurahashi, Nobusuke Tan: "Chronic estrogen replacement suppresses stress-induced cardiovascular responses in female rats"Circulation (Suppl). Vol 106, No 19. II-295 (2002)

Keiko Morimoto、Yoko Kurahashi、Nobusuke Tan：“慢性雌激素替代可抑制雌性大鼠应激诱发的心血管反应”Circulation（增刊）。

Keiko Morimoto, Yoko Kurahashi, Nobusuke Tan: "Chronic estrogen replacement suppresses stress-induced cardiovascular responses in female rats"Circulation (Suppl). Vol 106-No 19. II-295 (2002)

Keiko Morimoto、Yoko Kurahashi、Nobusuke Tan：“慢性雌激素替代可抑制雌性大鼠应激诱发的心血管反应”Circulation（增刊）。