Risk Evaluation for the Incidence of Congenital Hypothyroidism in Prenatal Multiple Exposure to Toxic Chemical Compounds

产前多次接触有毒化合物导致先天性甲状腺功能减退症发生的风险评估

基本信息

批准号：
13308031
负责人：
NAGAYAMA Junya
金额：
$ 26.54万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

项目摘要

Serum concentrations (Mean±S.D.) of TSH, fT_3 and fT_4, respectively, were 35.4±49.7 μIU/ml, 3.07±0.89 pg/ml and 1.09±0.32 ng/dl in 64 (male:38,female:26) positive neonates in the mass-screening for congenital hypothyroidism or cretinism. In 108 (male:58,female:50) negative neonates in this mass-screening, the respective serum concentrations were 8.56±5.62 μIU/ml, 3.60±0.84 pg/ml and 2.46 ± 0.67 ng/dl. Concentrations of TSH were significantly higher in the positive neonates than in the negative neonates, and those of fT_3 and fT_4 lower in the former ones than in the latter ones.Contamination levels (Mean±S.D., neonates with cretinism : normal neonates) of the organochlorine compounds in the breast milk samples which were collected within 4 weeks after childbirth were as follows: Dioxins (TEQ-pg/g);0.52±0.40:0.28±0.15,PCBs (ng/g);2.6±2.:1.5±1.3,DDT (ng/g) ;7.2±6.8:3.7±3.7,HCH (ng/g);2.7±3.4:1.3±1.2,Chlordane (ng/g);1.6±1.7:0.76±0.68 and HCB (ng/g);0.30±0.22:0.17±0.18. According to these analytical results, concentrations of the organochlorine compounds except HCH in the breast milk were significantly higher in the mothers who gave birth to neonates with congenital hypothyroidism than in those who gave birth to normal neonates.Consequently, this study suggests higher prenatal multiple exposures to such organochlorine compounds may cause congenital hypothyroidism in Japan.

Serum concentrations (Mean±S.D.) of TSH, fT_3 and fT_4, respectively, were 35.4±49.7 μIU/ml, 3.07±0.89 pg/ml and 1.09±0.32 ng/dl in 64 (male:38,female:26) positive neonates in the mass-screening for congenital hypothyroidism or cretinism.在108（男性：58，女性：50）在这种质量筛查中的负新生儿，相对血清浓度为8.56±5.62μIU/ml，3.60±0.84 pg/ml和2.46±0.67 ng/dl。正向新生儿的TSH的浓度明显高于负新生儿，而前者的ft_3和ft_4的浓度比后来的TSH浓度高于ft_3和ft_4的浓度。施加水平（平均±s.d。，新生儿，cr美毒素：正常的新生儿：正常的新生儿：正常的新生儿）在儿童后4周收集的有机牛奶中的TSH水平。（TEQ-PG/G）; 0.52±0.40：0.28±0.15，PCBS（NG/G）； 2.6±2。：1.5±1.3，DDT（NG/G）; 7.2±6.8：3.7±3.7，HCH（NG/G）（Ng/g）; 1.6±1.7：0.76±0.68和HCB（Ng/g）; 0.30±0.22：0.17±0.18。根据这些分析结果，在母亲的母亲外，有机氯化合物的浓度明显高于先天性甲状腺功能降临甲状腺功能低下的新生儿的浓度。