Risk Evaluation for the Incidence of Congenital Hypothyroidism in Prenatal Multiple Exposure to Toxic Chemical Compounds

产前多次接触有毒化合物导致先天性甲状腺功能减退症发生的风险评估

基本信息

批准号：
13308031
负责人：
NAGAYAMA Junya
金额：
$ 26.54万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

项目摘要

Serum concentrations (Mean±S.D.) of TSH, fT_3 and fT_4, respectively, were 35.4±49.7 μIU/ml, 3.07±0.89 pg/ml and 1.09±0.32 ng/dl in 64 (male:38,female:26) positive neonates in the mass-screening for congenital hypothyroidism or cretinism. In 108 (male:58,female:50) negative neonates in this mass-screening, the respective serum concentrations were 8.56±5.62 μIU/ml, 3.60±0.84 pg/ml and 2.46 ± 0.67 ng/dl. Concentrations of TSH were significantly higher in the positive neonates than in the negative neonates, and those of fT_3 and fT_4 lower in the former ones than in the latter ones.Contamination levels (Mean±S.D., neonates with cretinism : normal neonates) of the organochlorine compounds in the breast milk samples which were collected within 4 weeks after childbirth were as follows: Dioxins (TEQ-pg/g);0.52±0.40:0.28±0.15,PCBs (ng/g);2.6±2.:1.5±1.3,DDT (ng/g) ;7.2±6.8:3.7±3.7,HCH (ng/g);2.7±3.4:1.3±1.2,Chlordane (ng/g);1.6±1.7:0.76±0.68 and HCB (ng/g);0.30±0.22:0.17±0.18. According to these analytical results, concentrations of the organochlorine compounds except HCH in the breast milk were significantly higher in the mothers who gave birth to neonates with congenital hypothyroidism than in those who gave birth to normal neonates.Consequently, this study suggests higher prenatal multiple exposures to such organochlorine compounds may cause congenital hypothyroidism in Japan.

64例（男：38例，女：26例）阳性新生儿中TSH、fT_3和fT_4的血清浓度（平均值±标准差）分别为35.4±49.7 μIU/ml、3.07±0.89 pg/ml和1.09±0.32 ng/dl在先天性甲状腺功能减退症或克汀病的大规模筛查中。本次筛查阴性新生儿108例（男58例，女50例），血清TSH浓度分别为8.56±5.62 μIU/ml、3.60±0.84 pg/ml、2.46±0.67 ng/dl，均显着升高。阳性新生儿高于阴性新生儿，以及 fT_3 和 fT_4产后 4 周内采集的母乳样本中有机氯化合物的污染水平（平均值±标准差，克汀病新生儿：正常新生儿）如下：二恶英（TEQ- pg/g);0.52±0.40:0.28±0.15,PCB (ng/g);2.6±2.:1.5±1.3,DDT (ng/g);7.2±6.8:3.7±3.7,HCH (ng/g);2.7±3.4:1.3±1.2,氯丹 (ng/g) ) );1.6±1.7:0.76±0.68 和 HCB （ng/g）；0.30±0.22：0.17±0.18 根据这些分析结果，母乳中除六氯环己烷以外的有机氯化合物浓度，生育先天性甲状腺功能减退症新生儿的母亲显着高于生育新生儿的母亲。因此，这项研究表明，在日本，产前多次接触此类有机氯化合物可能会导致先天性甲状腺功能减退症。