Research for the development of an implantable artificial heart for permanent use

永久使用的植入式人工心脏的开发研究

基本信息

批准号：
13307041
负责人：
ABE Yusuke
金额：
$ 35.44万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

The purpose of this research was to develop a small implantable artificial heart with high performance to realize an artificial heart for permanent use. The rotary undulation pump, which is a quite new undulation pump, has been developing aiming to be driven with a magnetic levitation method. The first model was developed with a disk having permanent magnets and pump housing having electromagnets and hall sensors. The drive circuit was developed to examine the delta wired, Y wired and repulsion drive methods. In the repulsion method, the disk was driven by the magnetic repulsion. The result showed that the efficiency was quite lower in the repulsion method than in the other two methods. Therefore, the delta wired or Y wired methods with an active control of the gap distance was considered to be better than the repulsion method that required no active gap control. Based on the result, the second model in which spherical surface electromagnets were situated at the center of the ring-shaped disk that involves spherical surface permanent magnets was developed. The second model was driven without any hall sensors with newly developed drive circuit. The second model could generate 7L/min against 100mmHg of pressure load. To realize an active control of the gap distance, a gap sensor using optical fiber was experimentally developed. In this gap sensor, scattered light with blood was detected. The result showed the possibility that gap distance of 0 to 0.5mm could be controlled with this sensor. In the undulation pump total artificial heart using non-rotation undulation pump, forth model was developed to improve the problems in the third model. In the forth model, its total design, making procedure and drive mechanism were fully changed. A goat could survive for 11 days with the forth model.

这项研究的目的是开发一种高性能的小型植入式人工心脏，以实现永久使用的人工心脏。旋转式波动泵是一种新型波动泵，以磁悬浮方式驱动为目标而开发。第一个模型是采用具有永磁体的圆盘和具有电磁体和霍尔传感器的泵壳开发的。开发驱动电路是为了检验 Delta 线、Y 线和排斥驱动方法。在斥力方法中，磁盘由磁斥力驱动。结果表明，斥力法的效率明显低于其他两种方法。因此，主动控制间隙距离的 Delta 线或 Y 线方法被认为比不需要主动间隙控制的排斥方法更好。基于该结果，开发了第二个模型，其中球面电磁体位于涉及球面永磁体的环形盘的中心。第二种模型是在没有任何霍尔传感器的情况下使用新开发的驱动电路进行驱动的。第二个模型可以在 100mmHg 的压力负载下产生 7L/min 的流量。为了实现间隙距离的主动控制，实验研制了一种采用光纤的间隙传感器。在该间隙传感器中，检测到血液的散射光。结果表明该传感器可以控制0至0.5mm的间隙距离。在采用非旋转波动泵的波动泵全人工心脏中，针对第三种模型存在的问题，开发了第四种模型。第四个型号，其总体设计、制造程序和驱动机构都发生了全面改变。使用第四种模型，山羊可以存活 11 天。