Research for the development of an implantable artificial heart for permanent use

永久使用的植入式人工心脏的开发研究

基本信息

批准号：
13307041
负责人：
ABE Yusuke
金额：
$ 35.44万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

The purpose of this research was to develop a small implantable artificial heart with high performance to realize an artificial heart for permanent use. The rotary undulation pump, which is a quite new undulation pump, has been developing aiming to be driven with a magnetic levitation method. The first model was developed with a disk having permanent magnets and pump housing having electromagnets and hall sensors. The drive circuit was developed to examine the delta wired, Y wired and repulsion drive methods. In the repulsion method, the disk was driven by the magnetic repulsion. The result showed that the efficiency was quite lower in the repulsion method than in the other two methods. Therefore, the delta wired or Y wired methods with an active control of the gap distance was considered to be better than the repulsion method that required no active gap control. Based on the result, the second model in which spherical surface electromagnets were situated at the center of the ring-shaped disk that involves spherical surface permanent magnets was developed. The second model was driven without any hall sensors with newly developed drive circuit. The second model could generate 7L/min against 100mmHg of pressure load. To realize an active control of the gap distance, a gap sensor using optical fiber was experimentally developed. In this gap sensor, scattered light with blood was detected. The result showed the possibility that gap distance of 0 to 0.5mm could be controlled with this sensor. In the undulation pump total artificial heart using non-rotation undulation pump, forth model was developed to improve the problems in the third model. In the forth model, its total design, making procedure and drive mechanism were fully changed. A goat could survive for 11 days with the forth model.

这项研究的目的是开发一种具有高性能的小型植入人造心脏，以实现人造心脏以供永久使用。旋转起伏泵是一个非常新的起伏泵，一直在开发旨在通过磁性悬浮方法驱动的旨在。开发了第一个型号的磁盘具有带有电磁体和霍尔传感器的永久磁铁和泵外壳。开发了驱动电路，以检查三角洲有线，有线和排斥驱动方法。在排斥法中，磁盘是由磁排斥驱动的。结果表明，排斥法的效率比其他两种方法低。因此，具有空隙距离的主动控制的Delta有线或有线方法被认为比不需要主动GAP控制的排斥法更好。基于结果，开发了涉及球形表面永久磁体的环形表面电磁体的第二个模型。第二款模型是没有任何新开发的驱动电路的霍尔传感器的驱动器。第二个模型可以在100mmHg的压力负载下产生7L/min。为了实现对间隙距离的主动控制，实验开发了使用光纤的间隙传感器。在此间隙传感器中，检测到血液的散射光。结果表明，使用该传感器可以控制0至0.5mm的间隙距离的可能性。在使用非旋转起伏泵的起伏泵总人工心脏中，开发了第三个模型中的问题。在第四个模型中，其总设计，制作过程和驱动机制已完全改变。山羊可以通过第四模型生存11天。