Analysis of pain cognition by neuro-imaging

神经影像学分析疼痛认知

• 批准号: 12671464
• 负责人: SHIBATA Masahiko
• 金额: $ 2.05万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671464/
• 关键词: alllodynia; complex regional pain syndrome; FMRI; neuro-imaging; capsokin; neuro imaging

We demonstrated the anatomical area of cerebral activation triggered by non-nociceptive stimulation in a single patient with allodynia using functional MRI evaluations. Cerebral activation with non-nociceptive stimulus was measured for both the painful right foot and the healthy left foot. The same measurements were carried out 3 month later, after confirming that the alludynia triggered an increase in activity in the primary and second somatosensory area, inferior parietal lobe, insula, medial prefrontal cortex, anterior cingulated cortex and supplementary motor area, whereas stimulation to the healthy side only resulted n activity in the primary somatosensory area and inferior parietal lobe. Three months later, after the symptoms of allodynia had disappeared, the same stimuli to the right foot showed a decrease in activation of only the primary and second somatosensory area.Allodynia is secondary to nerve injury or tissue damage. The mechanism of how allodynia is perceived is essentially unknown. In our case the patient presented signs which fit the criteria for CRPS type I. Although these symptoms ceased naturally, the allodynia seen in our patient was common to that of CRPS type I. We believe that our findings are significant for understanding the pathophysiology of allodynia seen in CRP type I.

我们使用功能性 MRI 评估，展示了一名异常性疼痛患者中由非伤害性刺激触发的大脑激活的解剖区域。测量了疼痛的右脚和健康的左脚在非伤害性刺激下的大脑激活情况。 3个月后进行了相同的测量，确认异常疼痛引发了第一和第二体感区、顶下叶、岛叶、内侧前额叶皮层、前扣带皮层和辅助运动区的活动增加，而刺激健侧仅导致初级体感区和顶下叶的活动。三个月后，异常性疼痛症状消失后，对右足进行相同的刺激，仅第一和第二体感区的激活减少。异常性疼痛是继发于神经损伤或组织损伤的。异常性疼痛的感知机制基本上是未知的。在我们的病例中，患者表现出符合 CRPS I 型标准的体征。尽管这些症状自然消失，但我们患者中观察到的异常性疼痛与 CRPS I 型相同。我们相信，我们的发现对于理解异常性疼痛的病理生理学具有重要意义见于 CRP I 型。

项目成果

Masahiko Shibata et al.: "Complex regional pain syndrome Type I associated with amyotophic lateral selerosis"Clinical Journal of pain. 19. 69-70 (2003)

Masahiko Shibata 等人：“与肌萎缩侧索硬化相关的 I 型复杂区域疼痛综合征”《疼痛临床杂志》。

Takoo Iwakura, Masahiko Shibata et al.: "Functional MRI revealed the cultical representation of allodynia after immobilization"Journal of Japan Society of pain clinicians. Vol.10. 46-50 (2003)

Takoo Iwakura、Masahiko Shibata 等人：“功能 MRI 揭示了固定后异常性疼痛的文化表征”日本疼痛临床医师学会杂志。

岩倉健夫, 柴田政彦 他: "ギブス固定後に発現したallodying時の脳賦活領域-Functional MRIによる検討"日本ペイソクリニック学会誌. 10. 46-50 (2003)

Takeo Iwakura、Masahiko Shibata 等人：“石膏固定后的脑激活区域 - 使用功能性 MRI 进行检查”日本 Paysoclinic 学会杂志 10. 46-50 (2003)。

Masahiko Shibata et al.: "Complex regional pain synd1rome Type1 associated with amyotrophic lateral sclerosis"Clinical Journal of Pain. 19. 69-70 (2003)

Masahiko Shibata 等人：“与肌萎缩侧索硬化症相关的复杂区域疼痛综合征 1 型”《临床疼痛杂志》。