A new framework for multiscale and multiorientation image analysis and its application to medical volume data analysis

多尺度多方向图像分析新框架及其在医学体数据分析中的应用

• 批准号: 11680389
• 负责人: SATO Yoshinobu
• 金额: $ 2.18万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680389/
• 关键词: quantification; image measurement; blood vessels; pulmonary nodules; articular cartilage; accuracy validation; Thickness; diameter; 局部濃淡構造; 方向空間; ヘッセ行列; 固有値解析; Gaussフィルタ; Gaborフィルタ; ボリュームビジュアライゼーション; セグメンテーション

This project investigated a basic framework and clinical applications for the enhancement, segmentation, and quantification of line-like shapes such as blood vessels and sheet-like shapes such as articular cartilage in medical volume data. Based on multiscale Gaussian filters and the Hessian matrix of the volume function, line and sheet structures with various widths are enhanced. Local intensity structures are represented as continuous functions by further combining the gradient vectors. Medial axis/surface elements are locally determined based on the second-order approximations of local intensity structures. Diameter/thickness quantification is performed based on detected medial axis/surface elements, and various widths of structures are combined through multiscale integration. The utility of the framework was demonstrated by applications to the characterization of pulmonary nodules based on the spatial distribution of vessels surrounding pulmonary nodules, and articular cartilage thickness determination using real computed tomography (CT) and magnetic resonance (MR) volume data.

该项目研究了医疗体积数据中血管等线状形状和关节软骨等片状形状的增强、分割和量化的基本框架和临床应用。基于多尺度高斯滤波器和体积函数的Hessian矩阵，增强了各种宽度的线和片结构。通过进一步组合梯度向量，局部强度结构被表示为连续函数。中轴/表面元素是基于局部强度结构的二阶近似来局部确定的。基于检测到的中轴/表面元素进行直径/厚度量化，并通过多尺度积分组合各种宽度的结构。该框架的实用性通过基于肺结节周围血管的空间分布的肺结节表征的应用以及使用真实计算机断层扫描（CT）和磁共振（MR）体积数据确定关节软骨厚度的应用来证明。

项目成果

Y Sato ほか: "Limits to the accuracy of 3D thickness measurement in magnetic resonance images"電子情報通信学会技術研究報告[医用画像]. Vol.100,No.172(MI2000-30). 67-72 (2000)

Y Sato 等人：“磁共振图像中 3D 厚度测量的精度限制”IEICE 技术报告 [医学成像] 第 100 卷，第 172 号（MI2000-30）。

Nakanishi K, Tanaka H, Sugano N, Sato Y, UeguLchi T, Kubota T, Tamura S, Nakamura H: "MR-based three-dimensional presentation of cartilage thickness in the femoral head"European Radiology. 11(11). 2178-2183 (2001)

Nakanishi K、Tanaka H、Sugano N、Sato Y、UeguLchi T、Kubota T、Tamura S、Nakamura H：“基于 MR 的股骨头软骨厚度三维呈现”欧洲放射学。

Sato Y, Nakanishi K, Tanaka H, Nishii T, Sugano N, Nakamura H, Ochi T, Tamura S: "Limits to the Accuracy of 3D Thickness Measurement in Magnetic Resonance Images"Lecture Notes in Computer Science, (Proc. Forth International Conference on Medical Image Com

Sato Y、Nakanishi K、Tanaka H、Nishii T、Sugano N、Nakamura H、Ochi T、Tamura S：“磁共振图像中 3D 厚度测量精度的限制”计算机科学讲义，（Proc. 第四届国际会议）

H Shikata ほか: "Quantitative evaluation of the spatial distribution of vessels surrounding pulmonary nodules"Computer Assisted Radiology and Surgery : 14th International Symposium and Exhibition (CARS2000). 761-766 (2000)

H Shikata 等人：“肺结节周围血管空间分布的定量评估”计算机辅助放射学和外科：第 14 届国际研讨会和展览（CARS2000）（CARS2000）。

Shikata H., Kitaoka H., Keserci B., Sato Y., Shinichi T.: "Quantitative Evaluation of the spatial distribution of vessels surrounding pulmonary nodules"Computer Assisted Radiology and Surgery: 14th International Symposium and Exhibition (CARS2000), San Fr

Shikata H.、Kitaoka H.、Keserci B.、Sato Y.、Shinichi T.：“肺结节周围血管空间分布的定量评估”计算机辅助放射学和外科：第 14 届国际研讨会和展览 (CARS2000)，旧金山