Clinical study on cerebral oxygenation state and cerebral blood flow using near infrared spectroscopy

近红外光谱法测定脑氧合状态及脑血流量的临床研究

基本信息

批准号：
11671070
负责人：
ISOBE Kenichi
金额：
$ 2.37万
依托单位：
Kagawa Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

We have developed a new analytical system using full-spectrum near infrared spectroscopy, which allows optical spectroscopic measurements of cerebral oxy- and deoxyhemoglobin concentration, total hemoglobin, and cerebrovascular saturation. To investigate whether or not the mode of delivery produces differences in cerebral oxygenation, cerebral hemoglobin oxygen saturation was measured in 26 healthy term newborn infants immediately after birth. Infants in group 1 (n=20) were delivered vaginally, and those in group 2 (n=6) by elective cesarean section. The mean ± S.D. of cerebral hemoglobin oxygen saturation in group 1 increased rapidly afterbirth, from 29 ± 7 % at 2 min to 68 ± 6 % at 8.5 min, followed by an almost constant value (66 ± 7 % at 15 min). In comparison, cerebral hemoglobin oxygen saturation in group 2 also increased rapidly until 8.5 min, but after this time decreased significantly to 57 ± 5 % at 15 min after birth. This indicates that the mode of delivery has a marked influence on cerebral oxygenation immediately after birth.Near infrared topography with indocyanine green was used to measure regional cerebral blood flow (rCBF) in the temporal lobes of infants. The mean rCBF in infants without neural abnormality was 14.5 ± 3.1 ml/100 g/min. Moreover, in one asphyxiated infant with infarction and one infant with subdural and intracerebellar hemorrhage, it was demonstrated that the area of defective blood flow could be detected as well as it can by SPECT. This technique makes it possible to estimate rCBF distribution in infants at the bedside. Thus, in the future, evaluation of various neonatal illnesses should be feasible.

我们开发了一种使用全光谱近红外光谱的新分析系统，可以对脑氧合血红蛋白和脱氧血红蛋白浓度、总血红蛋白和脑血管饱和度进行光学光谱测量，以研究输送方式是否会产生脑氧合差异。第1组（n=20）中26名健康足月新生儿出生后立即测量脑血红蛋白氧饱和度。 2 (n=6) 通过选择性剖宫产，第 1 组的脑血红蛋白氧饱和度在产后迅速增加，从 2 分钟时的 29 ± 7 % 增加到 8.5 分钟时的 68 ± 6 %，随后几乎保持恒定值。（15 分钟时为 66 ± 7%）相比之下，第 2 组的脑血红蛋白氧饱和度也迅速增加，直到 8.5 分钟。此后在出生后15分钟显着下降至57±5％，这表明分娩方式对出生后立即脑氧合有显着影响。采用吲哚菁绿近红外地形图测量局部脑血流量（rCBF）。）在婴儿颞叶中，无神经异常的婴儿的平均 rCBF 为 14.5 ± 3.1 ml/100 g/min。通过对一名患有梗塞的婴儿和一名患有硬膜下和小脑内出血的婴儿进行研究，结果表明，该技术可以像 SPECT 一样检测出血流缺陷的区域，从而可以在床边估计婴儿的 rCBF 分布。因此，在未来，对各种新生儿疾病的评估应该是可行的。