Longitudinal study in an island community for aging effects on neurological findings and genetic factors on vascular dementia

在岛屿社区中进行的纵向研究，了解衰老对神经系统检查结果的影响以及血管性痴呆的遗传因素

• 批准号: 10670596
• 负责人: NAKAGAWA Masanori
• 金额: $ 1.86万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670596/
• 关键词: Aging effects on nervous system; Dementia; Genetic factors; Elders in an island community; Cerebrovascular disorders; MMSE; Polymorphism of ACE gene; Mitochondria DNA 5178; 脳血管性痴呆; 神経疾患

Purpose: To clarify aging effects on neurological findings and genetic factors related to vascular dementia, we analyzed neurological findings in elders living an island community and genetic factors in patients with cerebrovascular disorders (CVD).Methods and materials: 1) Neurological findings, dementia scale (MMSE) and dietary intake in the elders aged 60 year-old or over living in an island in Kagoshima, Japan were studied every other year. 2) Angiotensin converting enzyme (ACE) gene (II, ID, DD) and mitochondria 5178C/A polymorphism were analyzed in patients with CVD (127 cases) and the elders in an island (294 cases).Results: 1) The longitudinal study in the elders in an island. The score of MMSE in 590 elders was decreased with aging and the decrease ratio was higher in elders with aging. The incidence of cardiac disorders was significantly high in the elders without decrement of MMSE scale, but the incidence of renal disorders was high in the elders with decrement of the scale. Some dietary intake (tempura etc) showed negative correlation with MMSE score. 2) Genetic polymorphism and CVD. The mitochondrial DNA (mtDNA) polymorphism, 5178C, was significantly dominant in patients with CVD (p<0.01). MtDNA5178C was also dominant in all CVD subtypes without statistical difference between CVD subtypes. The women CVD patients with mt5178C showed higher total cholesterol and triglyceride levels in serum. ACE genotypes and allele frequency were not different between CVD patients and control or between CVD subtypes.Conclusions: In this study, we showed the longitudinal change of dementia scale and the factors that might be related to the change in elders living in an island. We also demonstrated the genetic factors that might be related to the onset of CVD.

目的：阐明对与血管痴呆有关的神经系统发现和遗传因素的衰老作用，我们分析了长者的神经系统发现，脑血管疾病患者（CVD）患者中的岛屿社区和遗传因素（CVD）。方法性和材料。 （MMSE）每隔一年就研究了60岁或超过60岁的长老居住在日本Kagoshima的一个岛上的饮食摄入量。 2）在CVD患者（127例）和岛屿的长者中，分析了血管紧张素转化酶（ACE）基因（II，ID，DD）和线粒体5178C/A多态性的。在一个小岛的长老中。随着衰老的衰老，MMSE在590名长者中的得分降低，而老年人的降低比率更高。在长者中，心脏疾病的发生率显着较高，而没有MMSE量表的降低，但肾脏疾病的发生率在长老中较高，随着量表的降低。一些饮食摄入量（tempura等）与MMSE评分显示出负相关。 2）遗传多态性和CVD。线粒体DNA（mtDNA）多态性为5178c，在CVD患者中显着主导（P <0.01）。 MTDNA5178C在所有CVD亚型中也占主导地位，而CVD亚型之间没有统计差异。 MT5178C的女性CVD患者在血清中显示出较高的总胆固醇和甘油三酸酯水平。 CVD患者和对照组或CVD亚型之间的ACE基因型和等位基因频率没有差异。结论：在这项研究中，我们显示了痴呆量表的纵向变化以及可能与居住在岛上的长老变化有关的因素。我们还证明了可能与CVD发作有关的遗传因素。

项目成果

Isashiki Y, Nakagawa M, Ohba N, et al.: "Retinal manifestations in mitochondrial diseases associated with mitochondrial DNA mutation"Acta Ophthalmologica Scandinavica. 76. 6-13 (1998)

Isashiki Y、Nakakawa M、Ohba N 等人：“与线粒体 DNA 突变相关的线粒体疾病中的视网膜表现”Acta Olookingmologica Scandinavica。

Takashima H, Nakagawa M, Suehara M, Saito M, Saito A, Kanzato N, Matsuzaki T,Hirata K, Terwilliger JD, Osame M.: "Gene for hereditary motor and sensory neuropathy (proximal dominant form) mapped to 3q13.1"Neuromuscular Disorders. 9. 368-371 (1999)

Takashima H, Nakakawa M, Suehara M, Saito M, Saito A, Kanzato N, Matsuzaki T,Hirata K, Terwilliger JD, Osame M.：“遗传性运动和感觉神经病（近端显性形式）映射到 3q13.1 的基因”

Yamagata H, Nakagawa M, Johnson K, Miki T.: "Further evidence for a major ancient mutation underlying myotonic dystrophy from linkage disequilibrium studies in the Japanese population."Journal of Human Genetics. 43. 246-249 (1998)

Yamagata H、Nakakawa M、Johnson K、Miki T.：“从日本人群的连锁不平衡研究中进一步证明了强直性肌营养不良背后的主要古代突变。”人类遗传学杂志。

Nakagawa M, Suehara M, Saito A, et al.: "A novel MPZ gene mutation in dominantly inherited neuropathy with focally folded myelin sheaths"Neurology. 52. 1271-1275 (1999)

Nakakawa M、Suehara M、Saito A 等人：“局灶性折叠髓鞘显性遗传性神经病中的新型 MPZ 基因突变”神经病学。

Ohkubo R, Nakagawa M, Higuchi I, et al.: "familial skeletal myopathy with atrioventricular block"Internal medicine. 38. 856-860 (1999)

Ohkubo R，Nakakawa M，Higuchi I，等：“家族性骨骼肌病伴房室传导阻滞”内科。