Effects of chronic exercise on the digestive System

长期运动对消化系统的影响

基本信息

批准号：
10680071
负责人：
MINATO Kumiko
金额：
$ 1.73万
依托单位：
Wayo Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2001
项目状态：
已结题

项目摘要

The purpose of the present study was to investigate (1) effect of voluntary running exercise on the exocrine pancreas and (2) effect of cholecystokinin (CCK) antagonist (CR1505) administration on the chronic exercise induced hypertrophy of acinar cells in rats.(1) Female F344 rats were divided into control, compulsory trained, and voluntary trained groups. The compulsory trained rats were exercised for 60 min on a treadmill (35m/ min), 5 days a week, for 8 weeks. The voluntary trained rats were exercised on a voluntary basis on a wheel ergometer with a load of 30% of their body weight every day. Mean running distance for the voluntary trained group was 5. 2Km. Pancreatic weight, protein content, and enzyme activity in the compulsory and voluntary trained groups were significantly higher than in the control group. Significant correlations between running distance and these parameters of the exocrine pancreas were observed. These results suggest that exocrine pancreas function may be accelerated by increases of daily total physical activity.(2) Female F344 rats were divided into control, CR1505, trained, CR1505+trained groups. The trained rats were exercised same as the compulsory trained rats of (1). CR1505 was administrated for 10mg/kg BW, 5 days a week, for 8 weeks. Pancreatic weight gain and pancreatic acinar cells hypertrophy were observed in the trained rats. But these changes were not recognized in CR1505+trained rats. Protein content and zymogen granulus increased in the trained and CR1505+trained rats. There are no significant differences in total DNA content in whole pancreas among the 4 groups. These results suggest that chronic exercise induced hypertrophy was mediated by CCK. However, chronic exercise induced increases of protein synthesis and storage were mediated by not only CCK. There must be another system of acceleration of the exocrine pancreas induced by chronic exercise.

本研究的目的是研究（1）自愿运动对外分泌胰腺的影响，以及（2）胆囊基蛋白（CCK）拮抗剂（CR1505）对大鼠慢性运动诱导腺细胞肥大的影响（1）。（1 ）女性F344大鼠被分为控制，受过强制性训练和自愿训练的群体。每周5天，在跑步机（35m/ min）上，在跑步机（35m/ min）中锻炼强制性训练的大鼠，持续8周。自愿训练的大鼠是在每天的30％体重的30％的情况下自愿运动的。自愿训练组的平均跑步距离为5.2km。强制性和自愿训练组中的胰腺重量，蛋白质含量和酶活性明显高于对照组。观察到跑步距离与外分泌胰腺的这些参数之间的显着相关性。这些结果表明，外分泌胰腺功能可能会通过每日全体体育锻炼的增加而加速。（2）女性F344大鼠被分为对照，CR1505，训练有素，CR1505+训练有素的组。训练有素的大鼠与强制性训练的大鼠（1）相同。 CR1505每周5天以10毫克/千克的速度管理8周。在训练有素的大鼠中观察到胰腺体重增加和胰腺细胞肥大。但是在CR1505+训练的大鼠中，这些变化尚未得到认可。在受过训练的和CR1505+训练的大鼠中，蛋白质含量和酶原颗粒增加。在这四组中，整个胰腺中的总DNA含量没有显着差异。这些结果表明，慢性运动诱导的肥大是由CCK介导的。然而，慢性运动诱导的蛋白质合成和储存的增加不仅是CCK介导的。慢性运动诱导的外分泌胰腺加速度必须有另一个加速系统。