Estimation of re-stenosis after PTCA by laboratory test of coagulation and fibrinolysis.

通过凝血和纤溶实验室测试评估 PTCA 后的再狭窄。

• 批准号: 10672191
• 负责人: KOMIYAMA Yutaka
• 金额: $ 1.79万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10672191/
• 关键词: PTCA; re-stenosis; prothrombin time; von Willebrand factor; thrombin-antithrombin III; tissue factor; プロトロンビン時間; 自然発症高血圧ラット

To detect flue re-stenosis after PTCA by laboratory tests of blood coagulation and fibrinolysis molecular markers, we made several clinical and experimental medical projects, as follows. Clinically, we demonstrated that the ratio of re-stenosis was dependent on the device and the levels of von Willebrand factor were linearly changed with the ratio. Experimentally, blood coagulation system, especially hypercoagulable state of spontaneously hypertensive (SHR) was studied by our newly modified laboratory test, diluted tissue factor prothrombin time (dil. PT), and thrombin-antithrombin (TAT) values were linearly changed with blood pressure and dil. PT.In the mice system, we observed a break down induced by verotoxin 2 and LPS by laboratory tests and biochemical analysis of blood coagulation and fibrinolysis system. Platelet count, TAT and fibrinogen was linearly changed with the fatal ratio and pathophysiological state. Moreover, m RNAs of tissue factor and PAI-1 in kidney were also changed with the values of laboratory tests and patholysiological state.

为了通过实验室凝血和纤维蛋白溶解分子标记的实验室测试来检测PTCA后的烟道再延伸，我们进行了几个临床和实验医学项目，如下所示。在临床上，我们证明了重新延缓的比率取决于该装置，并且von Willebrand因子的水平随比例线性改变了。在实验上，通过我们的新修饰的实验室测试，稀释的组织因子凝血酶原时间（DIL。PT）和凝血酶 - 抗凝血酶（TAT）值，通过血压和血压和血压和血压和血压抗凝血酶凝血酶凝血酶凝结剂（DIL。PT）来研究血液凝血系统，特别是可自发性高血压（SHR）的过度磁性状态（SHR）。 Dil。 pt。在小鼠系统中，我们观察到通过实验室测试和血液凝结和纤维蛋白溶解系统的生化分析，由Verotoxin 2和LPS引起的分解。血小板计数，TAT和纤维蛋白原通过致命比率和病理生理状态线性改变。此外，随着实验室测试和病理生物学状态的值，肾脏中组织因子和PAI-1的M RNA也发生了变化。

项目成果

Munakata M & Komiyama Y et al.: "Whole blood prothrombin time using diluted tissue factor is shortened in spontaneous hypertensive rats."Semin Thromb Hemost. 26. 97-100 (2000)

宗像中号

Sugatani J & Komiyama Y et al: "Activation of coagulation in C57BL/6 mice given verotoxin 2 (VT2) and the effect of co-administration of LPS with VT2."Thromb Res.. 100. 61-72 (2000)

菅谷 J

Yamamoto Y & Kamihata H et al.: "Factors associated with agiographic progression of moderate coronary artcry stenosis."Junkankika. 46(1). 78-83 (1999)

山本Y

Sugatani J & Komiyama Y et al.: "Activation of coagulation in C57BL/6 mice given verotoxin 2 (VT2) and the effect of co-administration of LPS with VT2."Thromb Res. 100(1). 61-72 (2000)

菅谷 J

山本克浩,神畠宏 他: "冠動脈造影所見により高度狭窄への進展を予測できるか."循環器科. 46. 78-83 (1999)

Katsuhiro Yamamoto、Hiroshi Kamabatake 等人：“可以通过冠状动脉造影结果预测严重狭窄的进展吗？”46. 78-83 (1999)