Mechanical Stimulation on the Facture Healing

机械刺激对骨折愈合的影响

• 批准号: 10671379
• 负责人: KOBAYASHI Akimasa
• 金额: $ 1.15万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671379/
• 关键词: Fracture; Bone healing; Mechanics; Non union; 仮骨

To evaluate the effect of the mechanical environment on the fracture healing of bone, we investigated the healing process under the application of loads applied in cyclic compression (0〜5N), cyclic bending (0.02rad) and cyclic torsion(0.02rad).Under compressive stimulation, the healing ratio increased as rapidly as that under non-stimulation group. The fracture line disappeared completely after 6 weeks. Under cyclic bending, the healing ratio increased over the first 2 weeks, and following this period it decresed. A small amount of callus was evident around the fracture site. Fracture healing was delayed under this condition. Under cyclic torsion, the healing ratio remained at zero throughout 6 weeks. Although the amount of callus produced was greatest, the fracture line was clearly evident after 6 weeks. The fracture did not heal under this condition.

为了评估机械环境对骨骨折愈合的影响，我们研究了循环压缩（0~5N）、循环弯曲（0.02rad）和循环扭转（0.02rad）载荷下的愈合过程。压缩刺激组的愈合率与非刺激组一样迅速，6周后骨折线完全消失。循环弯曲组的愈合率在前2周内增加，此后骨折线完全消失。在这种情况下，骨折部位周围有少量愈伤组织明显减少，在循环扭转的情况下，尽管骨痂产生量最大，但骨折线清晰。 6周后骨折未愈合。