Mechanical Stimulation on the Facture Healing

机械刺激对骨折愈合的影响

• 批准号: 10671379
• 负责人: KOBAYASHI Akimasa
• 金额: $ 1.15万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671379/
• 关键词: Fracture; Bone healing; Mechanics; Non union; 仮骨

To evaluate the effect of the mechanical environment on the fracture healing of bone, we investigated the healing process under the application of loads applied in cyclic compression (0〜5N), cyclic bending (0.02rad) and cyclic torsion(0.02rad).Under compressive stimulation, the healing ratio increased as rapidly as that under non-stimulation group. The fracture line disappeared completely after 6 weeks. Under cyclic bending, the healing ratio increased over the first 2 weeks, and following this period it decresed. A small amount of callus was evident around the fracture site. Fracture healing was delayed under this condition. Under cyclic torsion, the healing ratio remained at zero throughout 6 weeks. Although the amount of callus produced was greatest, the fracture line was clearly evident after 6 weeks. The fracture did not heal under this condition.

为了评估机械环境对骨骼断裂愈合的影响，我们研究了在循环压缩（0-5N）中施加的载荷，环状弯曲（0.02拉）和环状扭转（0.02rad）（0.02RAD）中的愈合过程中。裂缝线在6周后完全消失。在循环弯曲之后，愈合率在头2周内增加，并且在此期间脱离。骨折部位周围的证据是少量的愈伤组织。在这种情况下，断裂愈合延迟了。在循环扭转下，整个6周的愈合率保持为零。尽管产生的愈伤组织量最大，但骨折线显然是6周后的证据。骨折在这种情况下无法愈合。