Effects of exercise trainig and long-Term Survival in the BIO 14.6 cardiomyopathic Hamsters with chronic heart failure.

运动训练对患有慢性心力衰竭的 BIO 14.6 心肌病仓鼠的长期生存的影响。

基本信息

批准号：
10670651
负责人：
SATO Hideyuki
金额：
$ 1.98万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

Background. Although exercise training improves prognosis of ischemic heart failure, the effects on nonischemic heart failure are still unclear even in animal models. Because of metabolic bulnerability to sympathetic stimulation of failing hearts, exercise training may adversely affect the prognosis of nonischemic heart failure despite the beneficial effects on exercise capacity. To test the hypothesis, we examined the effect of exercise training with or without beta-blocker therapy on exercise capacity and prognosis of cardiomyopathic hamsters. Methods. We assigned 87 BIO 14.6 hamsters at 30 weeks of age into 3 groups ; sedentary control group (group C, n=27), exercise training group (group Ex, n=30), and exercise training plus beta-blocker group (group ExB, n=29). On Day 1 of the study, baseline treadmill exercise was performed to determine the maximal running speed at which animals could catch up. On Day 2, exercise training and medication were started. Treadmill exercise for 25 min … More at 40% of the baseline maximal speed was performed on every week days for 160 days in groups Ex and ExB.In group ExB, metoprolol of 1mg/kg/day, a cardioselective beta_1-blocker, was orally administered during the study. To assess exercise capacity, the maximal treadmill exercise was performed on Day 30 and Day 90. The survival rate was assessed . Results. The maximal treadmill speed gradually decreased in groups C and ExB.However, the initial decrease on Day 30 was not observed in group Ex, suggesting a short-term benefits of exercise training on exercise capacity. In contrast, the survival rate was lower throughout the study in group Ex than in group C (Kaplan-Meier, p<.01). This effect was partly but significantly attenuated in group ExB (p<.005). The survival rate on Day 160 was 77% in group C, 51% in group ExB, and only 33% in group Ex. Conclusion. Despite short-term benefits on exercise capacity, exercise training aggravated prognosis of cardiomyopathic hamsters. This effect was attenuated by cardioselective beta_1-blockade. Our results suggest that long-term exercise training promotes the progression of cardiomyopathy via Beta_1-adrenergic stimulation. Less

背景。尽管运动训练可以改善缺血性心力衰竭的预后，但即使在动物模型中，对非缺血性心力衰竭的影响仍然尚不清楚。由于对心脏失败的同情刺激的代谢强度，运动训练可能会对非缺血性心力衰竭的预后产生不利影响，尽管对运动能力产生了有益的影响。要检验假设，我们检查了具有或没有β受体阻滞剂疗法的运动训练对运动能力和心肌病剂的锻炼能力的影响。方法。我们在30周龄时分配了87个Bio 14.6仓鼠，分为3组；久坐的对照组（C组，n = 27），运动训练组（EX组，n = 30）和运动训练加上Beta-Blocker组（组EXB，n = 29）。在研究的第1天，进行了基线跑步机运动，以确定动物赶上的最大跑步速度。在第2天，开始运动训练和药物。跑步机运动25分钟…在研究过程中，每隔160天进行基线最大速度的40％，持续160天。为了评估运动能力，在第30天和第90天进行了最大的跑步机运动。评估了生存率。结果。在C组和EXB组中，最大跑步机速度逐渐降低。相反，在整个研究中，在EX组中，生存率低于C组（Kaplan-Meier，p <.01）。这种作用部分是在EXB组中显着减弱的（p <.005）。第160天的存活率为C组为77％，组EXB的生存率为51％，EX组的存活率仅为33％。结论。尽管运动能力短期益处，但锻炼训练心肌病的仓鼠的总预后总计预后。这种效果被心脏效应beta_1-blockade减弱。我们的结果表明，长期运动训练通过β_1-肾上腺素能刺激促进心脏病的进展。较少的