Effects of exercise trainig and long-Term Survival in the BIO 14.6 cardiomyopathic Hamsters with chronic heart failure.

运动训练对患有慢性心力衰竭的 BIO 14.6 心肌病仓鼠的长期生存的影响。

基本信息

批准号：
10670651
负责人：
SATO Hideyuki
金额：
$ 1.98万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

Background. Although exercise training improves prognosis of ischemic heart failure, the effects on nonischemic heart failure are still unclear even in animal models. Because of metabolic bulnerability to sympathetic stimulation of failing hearts, exercise training may adversely affect the prognosis of nonischemic heart failure despite the beneficial effects on exercise capacity. To test the hypothesis, we examined the effect of exercise training with or without beta-blocker therapy on exercise capacity and prognosis of cardiomyopathic hamsters. Methods. We assigned 87 BIO 14.6 hamsters at 30 weeks of age into 3 groups ; sedentary control group (group C, n=27), exercise training group (group Ex, n=30), and exercise training plus beta-blocker group (group ExB, n=29). On Day 1 of the study, baseline treadmill exercise was performed to determine the maximal running speed at which animals could catch up. On Day 2, exercise training and medication were started. Treadmill exercise for 25 min … More at 40% of the baseline maximal speed was performed on every week days for 160 days in groups Ex and ExB.In group ExB, metoprolol of 1mg/kg/day, a cardioselective beta_1-blocker, was orally administered during the study. To assess exercise capacity, the maximal treadmill exercise was performed on Day 30 and Day 90. The survival rate was assessed . Results. The maximal treadmill speed gradually decreased in groups C and ExB.However, the initial decrease on Day 30 was not observed in group Ex, suggesting a short-term benefits of exercise training on exercise capacity. In contrast, the survival rate was lower throughout the study in group Ex than in group C (Kaplan-Meier, p<.01). This effect was partly but significantly attenuated in group ExB (p<.005). The survival rate on Day 160 was 77% in group C, 51% in group ExB, and only 33% in group Ex. Conclusion. Despite short-term benefits on exercise capacity, exercise training aggravated prognosis of cardiomyopathic hamsters. This effect was attenuated by cardioselective beta_1-blockade. Our results suggest that long-term exercise training promotes the progression of cardiomyopathy via Beta_1-adrenergic stimulation. Less

背景：尽管运动训练可改善缺血性心力衰竭的预后，但即使在动物模型中，其对非缺血性心力衰竭的影响仍不清楚，因为衰竭心脏的代谢易受交感神经刺激，因此运动训练可能会对非缺血性心力衰竭的预后产生不利影响。为了检验这一假设，我们研究了有或没有β受体阻滞剂治疗的运动训练对心肌病仓鼠的运动能力和预后的影响。 87 只 30 周龄 BIO 14.6 仓鼠分为 3 组；久坐对照组（C 组，n=27）、运动训练组（Ex 组，n=30）和运动训练加 β 受体阻滞剂组（ExB 组，n=30） =29）。在研究的第一天，进行基线跑步机运动以确定动物可以赶上的最大跑步速度，然后开始运动训练和药物治疗。 Ex 组和 ExB 组每周以 40% 基线最大速度进行跑步机锻炼 25 分钟，持续 160 天。在 ExB 组中，口服美托洛尔 1mg/kg/天，一种心脏选择性 β1 受体阻滞剂为了评估运动能力，在第 30 天和第 90 天进行最大跑步机运动。评估最大结果。 C 组和 ExB 组的跑步机速度逐渐降低。然而，Ex 组在第 30 天没有观察到最初的下降，这表明运动训练对运动能力有短期益处。相反，在整个研究过程中，存活率较低。 Ex 组比 C 组（Kaplan-Meier，p<.01）在 ExB 组中部分但显着减弱（p<.005）。C 组第 160 天的存活率为 77%。 ExB 组为 51%，Ex 组仅为 33%。结论尽管运动训练会加重心肌病仓鼠的预后，但长期的心脏选择性 β1 阻断会减弱这种影响。运动训练通过β_1-肾上腺素能刺激促进心肌病的进展。