Strong Solid Bases for Organic Synthesis

有机合成的强固体碱

• 批准号: 10450301
• 负责人: BABA Toshihide
• 金额: $ 4.61万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10450301/
• 关键词: Base catalysis; Strong solid base; Base strength; Organic synthesis; C-C bond formation; Si-C C-C bond formation; アニオン; アニソン; カルボアニオン; カリウムアミド; シリルアセチレン; ノーアルキン

Active sites (centers) of solid-base play important roles of (1) the abstraction of protons from the reactants, (2) activation of reactants without proton abstraction and (3) cooperative action of acidic and basic sites. In present short review, the roles (1) and (2) were focused to understand the catalysis by strong solid-bases such as KNHィイD22ィエD2 on alumina and KF on alumina, respectively. The preparation and characterization of these catalysts were described. To extend utility of the strong solid-base catalysts, they were applied to various reactions including the isomerization of alkenes and alkynes, the dimerization of alkynes, Tishchenko reaction, and the formation of Si-C, Si-N and Si-O bonds.

固体碱的活性位点（中心）起着以下重要作用：（1）从反应物中夺取质子，（2）在不夺取质子的情况下活化反应物，以及（3）酸性和碱性位点的协同作用。角色（1）和（2）分别侧重于了解强固体碱（例如氧化铝上的 KNH 和氧化铝上的 KF）的催化作用，以及它们的制备和表征。为了扩展强固体碱催化剂的实用性，它们被应用于各种反应，包括烯烃和炔烃的异构化、炔烃的二聚、Tishchenko 反应以及 Si-C、Si-N 和 Si 的形成。 -O键。

项目成果

Toshihide Baba, Hisashi Kizuka, Haruhisa Handa and Yoshio Ono: "Reaction of Ketones or Aldehydes with 1-Alkynes over Solid-Base Catalysts"Appl. Catal. A, Gneral. (in press).

Toshihide Baba、Hisashi Kizuka、Haruhisa Handa 和 Yoshio Ono：“酮或醛与 1-炔烃在固体基催化剂上的反应”应用。

Toshihide Baba, Satoru Hikita, Haruhisa Handa, and Yoshio Ono: "Catalytic Property of Europium Supported on Alumina from Its Ammoniacal Solution"Res. Chem. Intermediates. 24. 495-505 (1998)

Toshihide Baba、Satoru Hikita、Haruhisa Handa 和 Yoshio Ono：“氨溶液中氧化铝负载铕的催化性能”Res。

E,Suzuki Y.Ono: "Disproportionation of triethoxysilane over KF/Al_2O_3 and heat-treated hydrotalcite" Applied Catalysis General. 166. 419-424 (1998)

E，Suzuki Y.Ono：“三乙氧基硅烷在 KF/Al_2O_3 和热处理水滑石上的歧化”应用催化综述。

Toshihide Baba, Akiko Kato, Hiroko Yuasa, Fumihiko Toriyama, Haruhisa Handa, and Yoshio Ono: "Metathesis of Siliylalkynes and Cross-Metathesis of Siliylalkyne and 1-Alkyne over Solid-Base Catalysts"J. Catal.. 176. 488-494 (1998)

Toshihide Baba、Akiko Kato、Hiroko Yuasa、Fumihiko Toriyama、Haruhisa Handa 和 Yoshio Ono：“甲硅烷基炔的复分解以及甲硅烷基炔和 1-炔在固体基催化剂上的交叉复分解”J。

Toshihide Baba, Akiko Kato, Hiroko Yuasa, Fumihiko Toriyama, Haruhisa Handa, and Yoshio Ono: "New Si-C Bond Forming Reactions over Solid-Base Catalysts"Catal. Today. 44. 271-276 (1998)

Toshihide Baba、Akiko Kato、Hiroko Yuasa、Fumihiko Toriyama、Haruhisa Handa 和 Yoshio Ono：“固体基催化剂上的新 Si-C 键形成反应”催化剂。