High-Performance Chiral Separation Systems Based on Polysaccharide Derivatives
基于多糖衍生物的高性能手性分离系统
基本信息
- 批准号:10208206
- 负责人:
- 金额:$ 27.78万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research on Priority Areas (B)
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1. Cyclohexylcarbamates of cellulose and amylose were prepared and their resolving abilities for enantiomers were evaluated as chiral stationary phases (CSPs) for high-performance liquid chromatography (HPLC). The CSPs showed high resolving abilities, and could also be used for thin-layer chromatography (TLC). These derivatives were soluble in chloroform and exhibited chiral discrimination to some chiral compounds in ^1H NMR spectroscopy as well as in HPLC.2. Chitin is a readily available polysaccharide with 1,4-glycosidic linkage as well as cellulose and amylose. However, until recently this polysaccharide had not successfully been used for the preparation of CSPs for HPLC. We have found a suitable method for the preparation of chitin carbamates, such as 3,5-dimethyl, 4-chloro and 4-trifluoromethylphenylcarbamates, with relatively high chiral recognition abilities. The CSPs of chitin 3,5-dimethyl and 3,5-dichlorophenylcarbamates can be used in the presence of chloroform as a component … More of eluents owing to their poor solubilities in the eluent.3. We studied the molecular recognition in crystalline inclusion compounds of bile acids and their derivatives. The existence of many asymmetric carbons and multiple hydrogen bonding groups enabled us to check notable effects of any point mutations of their molecular structures on chiral recognition. Recrystallization of the derivatives from liquid organic compounds afforded inclusion crystals suitable for single-crystal X-ray analysis. The host assemblies mostly have bilayered structures which involve one-dimensional spaces with some pockets. This research led to the reasonable interpretation of molecular recognition in size, shape, polarity and chirality.4. We have found that a membrane which contains an oligopeptide residue from an L-amino acid and is imprinted by a L-amino acid derivative recognizes the L-isomer in preference to the corresponding D-isomer, and vice versa. Enantioselective electrodialysis was attained with the membranes reflecting their adsorption selectivity. Less
1。制备纤维素和双链淀粉的环己基核酸酯,并将其对映异构体的分辨能力评估为高性能液相色谱(HPLC)的手性静止相(CSP)。 CSP具有高分辨率的能力,也可以用于薄层色谱法(TLC)。这些衍生物在氯仿和暴露于 ^1H NMR光谱中的某些手性化合物以及HPLC.2中的手性歧视中是固体的。几丁质是一种容易获得的多糖,具有1,4-糖苷键以及纤维素和淀粉酶。但是,直到最近,这种多糖还没有成功用于为HPLC制备CSP。我们找到了一种适合制备甲壳质载体的方法,例如3,5-二甲基,4-氯和4-三氟甲基苯基钙甲甲酸酯,具有相对较高的手性识别能力。几丁质3,5-二甲基的CSP和3,5-二氯苯基碳酸盐可以在氯仿存在下用作成分……由于它们在弹性中的溶解度差,更多的弹性。3。我们研究了胆汁酸及其衍生物的结晶包含化合物中的分子识别。许多不对称碳和多个氢键组的存在使我们能够检查其分子结构对手性识别的任何点突变的显着影响。液体有机化合物的衍生物的重结晶提供了适合单晶X射线分析的包含晶体。主机组件大多具有双层结构,涉及带有一些口袋的一维空间。这项研究导致了对大小,形状,极性和手性的分子识别的合理解释。4。我们发现,含有来自L-氨基酸的寡肽残基的膜,并由L-氨基酸衍生物印记,识别l-异构体优先于相应的D-异构体,反之亦然。对映选择性透析与反映其吸附选择性的膜相连。较少的
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
M.Yoshikawa: "Chiral Recognition of N-α-acetyltryptophans with Molecularly Imprinted Polymeric Membranes Containing DVNE Derivatives" Sen-i Gakkaishi. 54. 77-84 (1998)
M. Yoshikawa:“含有 DVNE 衍生物的分子印迹聚合物膜对 N-α-乙酰色氨酸的手性识别”Sen-i Gakkaishi 54. 77-84 (1998)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Y.Kondo: "Molecularly imprinted polyamide membranes for chiral recognition"Polym.Bull.. 44. 517-524 (2000)
Y.Kondo:“用于手性识别的分子印迹聚酰胺膜”Polym.Bull.. 44. 517-524 (2000)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
M. Chikada: "Intercalation and Polymerization in Chenodeoxycholic Acid Channels with Retention of a Crystalline State"Polym. J.. 31. 1061-1064 (1999)
M. Chikada:“鹅去氧胆酸通道中的嵌入和聚合并保留晶态”聚合物。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
C.Yamamoto: "Computational Studies on Chiral Discrimination Mechanism of Phenylcarbamate Derivatives of Cellulose"Bull.Chem.Soc.Jpn.. 72. 1815-1825 (1999)
C.Yamamoto:“纤维素苯基氨基甲酸酯衍生物的手性判别机制的计算研究”Bull.Chem.Soc.Jpn.. 72. 1815-1825 (1999)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Y.Hishikawa: "Selective Inclusion Phenomena in Lithocholamide Crystal Lattices;Design of Bilayered Assemblies through Ladder-Type Hydrogen Bonding Network" Chem.Lett.1289-1290 (1998)
Y.Hishikawa:“石胆酰胺晶格中的选择性包含现象;通过梯型氢键网络设计双层组件”Chem.Lett.1289-1290 (1998)
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- 影响因子:0
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OKAMOTO Yoshio其他文献
OKAMOTO Yoshio的其他文献
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{{ truncateString('OKAMOTO Yoshio', 18)}}的其他基金
Advances in Theory and Design Principles of Counting AlgorithmsBased on Polyhedral Combinatorics
基于多面体组合的计数算法理论与设计原理研究进展
- 批准号:
21700009 - 财政年份:2009
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Algorithmic exact approach to game theory on graphs and networks
图和网络博弈论的算法精确方法
- 批准号:
18710130 - 财政年份:2006
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Studies on Asymmetric Synthesis, Structure, and Function of Optically Active Poly(methacrylamide) Derivatives
光学活性聚甲基丙烯酰胺衍生物的不对称合成、结构与功能研究
- 批准号:
17550116 - 财政年份:2005
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Helix-Sense-Selective Radical Polymerization of Methacrylamides
甲基丙烯酰胺的螺旋选择性自由基聚合
- 批准号:
14350485 - 财政年份:2002
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of New Chiral Packing Material for HPLC Based on the Structure Control of Polysaccharide Derivatives and Their Immobilization onto Silica Gel
基于多糖衍生物结构控制及其硅胶固定化的新型高效液相色谱手性填料的研制
- 批准号:
13355033 - 财政年份:2001
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development and Application of Precise-Stereocontrolled Polymerization of Novel Acrylic Monomers
新型丙烯酸单体精密立体控制聚合技术的开发及应用
- 批准号:
11450355 - 财政年份:1999
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
High-Performance Separation Systems Based on Kinetic Molecular Recognition
基于动力学分子识别的高性能分离系统
- 批准号:
10208103 - 财政年份:1998
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas (B)
Teaching Materials of Geophysical Observation-Earthquakes and Geomagnetism-
地球物理观测教材-地震与地磁-
- 批准号:
09680207 - 财政年份:1997
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of Efficient Chiral Packing and Their Recognition Mechanism
高效手性堆积及其识别机制的研究进展
- 批准号:
08559008 - 财政年份:1996
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Studies on Stereocontrol of Free-Radical Polymerization
自由基聚合立体调控的研究
- 批准号:
07455370 - 财政年份:1995
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
相似海外基金
Effect of supermolecular structure of cellulosic materials on chiral discrimination
纤维素材料超分子结构对手性辨别的影响
- 批准号:
14560130 - 财政年份:2002
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of highly sensitive system for determination of absolute configuration of natural-products by labelling with chiral fluorescent reagents
开发手性荧光试剂标记测定天然产物绝对构型的高灵敏度系统
- 批准号:
11556019 - 财政年份:1999
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Development of general chiral method for chiral branched-chain carboxylic acids
手性支链羧酸通用手性方法的发展
- 批准号:
11660100 - 财政年份:1999
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
High-Performance Separation Systems Based on Kinetic Molecular Recognition
基于动力学分子识别的高性能分离系统
- 批准号:
10208103 - 财政年份:1998
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas (B)
Development of chiral fluorescent derivatization reagents for discrimination of enantiomers having chiral centers far remote from the derizatizable functional groups and their application to determination of absolute configuration of natural products
手性荧光衍生试剂的开发,用于区分手性中心远离可衍生官能团的对映体,及其在天然产物绝对构型测定中的应用
- 批准号:
10460046 - 财政年份:1998
- 资助金额:
$ 27.78万 - 项目类别:
Grant-in-Aid for Scientific Research (B).