Targeting TGF-beta proteins to control animal reproduction

靶向 TGF-β 蛋白来控制动物繁殖

• 批准号: DP220101179
• 负责人: Dr Kelly Walton
• 金额: $ 35.99万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101179
• 关键词: Targeting; TGF; beta; proteins; control

This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide a non-surgical method of contraception in companion/feral species, which should address the large unmet need for fertility control in these animals.

该项目旨在开发一套新型生物制剂来控制雌性哺乳动物的生育能力。该项目期望证明针对单一类别的卵巢蛋白将增强或抑制卵子的产生。该项目的预期成果是：(1) 改变家畜饲养方式，通过增加畜群/羊群规模，为农业带来显着效益；(2) 为伴侣/动物提供非手术避孕方法。野生物种，这应该可以解决这些动物对生育控制的巨大未满足的需求。