Targeting TGF-beta proteins to control animal reproduction

靶向 TGF-β 蛋白来控制动物繁殖

• 批准号: DP220101179
• 负责人: Dr Kelly Walton
• 金额: $ 35.99万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101179
• 关键词: Targeting; TGF; beta; proteins; control; Targeting; TGF; beta; proteins; control

This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide a non-surgical method of contraception in companion/feral species, which should address the large unmet need for fertility control in these animals.

该项目旨在开发一套新型的生物制剂来控制女性哺乳动物的生育能力。该项目预计将证明，靶向一类卵巢蛋白将增强或抑制卵的产生。该项目的预期结果是（1）改变牲畜动物的繁殖，这应该通过增加的牛群/羊群大小为农业产生带来的重大好处，（2）在这些动物中应解决对伴侣/野性物种的非手术避孕方法，这应该解决这些动物的巨大不受欢迎的需求。