STUDY FOR THE CAUSE OF DELAYED GASTRIC EMPTYING AFTER PYLORUS-PRESERVING PANCREATODUODENECTOMY

保留幽门的胰腺十二指肠切除术后胃排空延迟的原因研究

基本信息

批准号：
08671482
负责人：
TAKAHASHI Shin
金额：
$ 1.41万
依托单位：
KEIO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

项目摘要

We performed the experiments described below in mongrel dogs in order to explain the cause of delayd gastric emptying after pylorus-preserving pancreatoduodenectomy (PPPD). Strain gauge force transducers (SGT) were attached to the body of the stomach, the antrum, and the lifted jejunum, in three groups of animals : a control group, a PPPD-acute group, and a PPD-chronic group, and intestinal motility was observed. Gastric emptying was simultaneously monitored by blood acetaminophen aconcentrations, and blood motilin concentrations were also determined.In the control group, intermittent migrating complexes (IMC) having a mean duration of 15 min 42 sec occurred regularly with a mean cycle of 108 min in the interdigestive state in the body and antrum. In the PPPD-acute dogs, emptying was delayd, and retention of gastric contents and the patency of the pyloric ring were confirmed. In the PPPD chronic dogs, a strong contraction group resembling IMC emerged on POD 14 in the body and antrum, b … More ut the cycle and the duration were both irregular. When this contraction group and IMC were compared, the initiation cycle and the duration in the contraction group on POD 14 were significantly shorter compared to the IMC.On POD 28, the duration was significantly shorter, but there was no difference in the initiation cycle.The pyloric ring of the dogs was patent in the early period after PPPD,but the fact that IMD did not occur in the body or the antrum and that a strong contraction group of short duration occurred irregularly appeared to be responsible for the retention of gastric contents. In the chronic period, a strong contraction group resembling IMC was observed, and the gastric emptying recovered. However, the blood motilin concentrations when this strong contraction group emerged were lower than when IMC occurred in the control group, and the decrease in motilin production associated with removal of the duodenum also appeared to be one of the causes that led to the retention of gastric contents after PPPD. Less

我们在杂种狗中进行了下述实验，以解释在保留幽门的胰十二指肠切除术 (PPPD) 后胃排空延迟的原因，将应变计力传感器 (SGT) 连接到胃体、胃窦和提升的胃体上。空肠，在三组动物中：对照组、PPPD急性组和PPD慢性组，并观察胃排空。同时监测血液对乙酰氨基酚浓度，并测定血液胃动素浓度。在对照组中，平均持续时间为 15 分 42 秒的间歇性迁移复合物 (IMC) 有规律地出现，在消化间期状态下平均周期为 108 分钟。 PPPD 急性犬的身体和胃窦排空延迟，胃内容物滞留，幽门通畅。在PPPD慢性犬中，在身体和胃窦的POD 14处出现了重新组装IMC的强烈收缩组，但是当比较该收缩组和IMC时，其周期和持续时间均不规则。与IMC相比，POD 14时收缩组的周期和持续时间显着缩短。POD 28时，持续时间显着缩短，但起始周期没有差异。狗的幽门环PPPD 后的早期是明显的，但 IMD 并未发生在体内或胃窦，并且不规则地发生短时间的强烈收缩群，这似乎是慢性期胃内容物滞留的原因。观察到强收缩组重新组装IMC，并且胃排空恢复，但是，该强收缩组出现时的血液胃动素浓度低于对照组发生IMC时，并且与去除相关的胃动素产生减少。十二指肠似乎也是导致PPPD后胃内容物滞留的原因之一。