Analysis of T cell epitope in Asian type multiple sclerosis

亚洲型多发性硬化症T细胞表位分析

• 批准号: 08670712
• 负责人: KIRA Jun-ichi
• 金额: $ 1.34万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670712/
• 关键词: multiple sclerosis; disease susceptibility; HLA; Japanese; Asian; Helper T cell; HLA-DPB1^<**>0501; IFNgamma; HLA DPB1^*0501; multiple sclerosis; magnetic resonance imaging; Asian; Western; atopy; IgE; mite

We studied the polymorphism of HLA-A-DPBl gene in 90 Japanese patients with multiple sclerosis (MS) including 44 patients with Asian type MS showing recurrent opticomyelitis and 46 patients with Westem type MS with disseminated central nervous system involvement. We earlier found a significant association between an HLA-DRB1^<**> 1501-DRB5^<**>0101 haplotype and susceptibility to Western type but not Asian type MS.In the present work, we found that the frequency of DPB1^<**>0501 allele was significantly increased in the patients with Asian type MS (88.6% vs. 63.0%, p^<COIT><0.05), but not Western type MS,as compared with findings in healthy control subjects. In addition, Asian type MS showed a higher age of onset, a higher Expanded Disability Status Scale score, a greater visual impairment, a higher frequency of hyperprolactinemia and higher cell counts and protein contents in the cerebrospinal fluid than did Westem type MS.Our data provide further evidence that Asian and Western type MS are distinct regarding the immunogenetic backgound, and suggested that Asian type MS is a HLA-DPBl^<**>0501-restricted autoimmune disease.

我们研究了90名日本多发性硬化症患者（MS）中HLA-A-A-DPBL基因的多态性，包括44例亚洲型MS患者，显示复发性眼肌炎和46例WestEM型MS患者，患有散布的中枢神经系统参与。我们早些时候发现HLA-DRB1^<**> 1501-DRB5^<**> 0101单倍型和对西方类型的敏感性，但不是亚洲类型的MS.在当前工作中，我们发现DPB1^的频率是与健康对照组相比，亚洲型MS患者的0501等位基因显着增加（88.6％vs. 63.0％，P^<COIT> <0.05），而不是西部型MS。此外，亚洲类型的MS显示出更高的发病年龄，扩大的残疾状态量表评分，更大的视觉障碍，高授激素血症的频率更高，细胞计数和较高的细胞计数和蛋白质含量较高提供进一步的证据表明，亚洲和西方型MS在免疫遗传的背景下是不同的，并建议亚洲型MS是HLA-DPBL^<**> 0501限制性自身免疫性疾病。

项目成果

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Kira J 等人：“人类 T 细胞嗜淋巴细胞病毒 I 型感染与血管性痴呆的关联。”

Kira J,et al.: "Multiple sclerosis with mite antigen-specific IgE." J Neurol Sci,in press.

Kira J 等人：“与螨抗原特异性 IgE 相关的多发性硬化症。”

Kira J,Yamasaki K,YamamotoI,Mizusawa H,Yoshino S,et al: "Induction of chronic infiammatory arthropathy and mesenchymal tumors in rats infected with HTL V-I." J AIDS Hum Retroviral. 16. 380-392 (1997)

Kira J、Yamasaki K、YamamotoI、Mizusawa H、Yoshino S 等人：“感染 HTL V-I 的大鼠诱发慢性炎症性关节病和间质肿瘤。”

Kira J, et al.: "Western versus Asian types of multiple sclerosis:immunogentically and clinically distinct disorders." Ann Neurol. 140. 569-574 (1996)

Kira J 等人：“西方类型与亚洲类型的多发性硬化症：免疫原性和临床上不同的疾病。”

Kira J, et al.: "A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein(MBP)in a patients with macroglobulinemia." J Neurol Sci. 148. 47-52 (1997)

Kira J 等人：“一种新型单克隆抗体，可与巨球蛋白血症患者的高分子量神经元细胞质蛋白和髓磷脂碱性蛋白 (MBP) 发生反应。”