Preparation of Arificial Stoma Using Temperature-Responsive Hydrogel

使用温度响应水凝胶制备人工造口

• 批准号: 08558102
• 负责人: AOYAGI Takao
• 金额: $ 3.65万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08558102/
• 关键词: Stoma; Hydrogel; Temperature-responsive; Poly (N-isopropylacrylamide); Poly (ethylene glycol); silicone; ポリイソプロピルアクリルアミド; 複合材料; 温度応答性

After excision of rectum or colon by some disease such as cancer, stoma that is hole for excretion is built up at an abdominal wall. It was formed using intestinal tube, however, its shape of the hole influence their social life because it dominates stoma care. From this background, we performed the research with respect to fabrication of completely artificial stoma using temperature-responsive hydrogel. In this project, we aimed acceleration of rapid volume phase transition of hydrogel in response to temperature change for rapid open and shut system of the hole. Moreover, hybridization of the temperature-responsive hydrogel and silicone rubber and application of this material to open shut system of artificial stoma were studied.Generally, poly(N-isopropylacrylamide) (PIPAAm) hydrogels form water-impermeable skin layer at the surface around its LCST.This skin layer prevent the gel from deswelling and rapid shrinking. To control the skin layer formation, we newly prepared the hydrogel c … More omposed of PIPAAm network grafted with polyethylene glycol (PEG). Our concept is that the hydrophilic PEG chains would form water path in the skin layer and as a result, water could go out from the gel in course of shrinking. PEG-graft PIPAAm gel showed very rapid shrinking and its rate depended on the grafted ratio of PEG.It was revealed that the PEG-grafting in PIPAAm hydrogel was one of the useful method for acceleration of shrinking.Separately, we prepared macromonomer composed of copolymer of IPAArn and N,N-dimethylacrylamide (DMAAm). For more hydrophilic character of DMAAm, LCST is higher than that of PIPAAm homopolymer. We prepared the novel PIPAAm hydrogel grafted with copolymer of IPAAm and DMAAm using macromonomer prepared. When we increased temperature above LCST of PIPAAm below that of macromonomer, PIPAAm could not shrink by highly hydrated macromonomer. Once we increased temperature above LCST of macromonomer, the hydrogel shrunk very rapidly. We also revealed that controlling of LCST of graft chain could accelerate the shrinking of the PIPAAm hydrogel. Less

但是，在通过苏氏蛋白酶（例如癌症）切除后，造口构症状，但其孔的形状会影响其社交生活，因为它从这种背景中占主导。研究了Al凹痕。在其LCST周围的表面上，聚凝胶（PIPAAM）水凝胶形成了可渗透的皮肤层。用聚乙烯甘氨酸（PEG）接枝。 N-二甲基丙烯酰胺（DMAAM）。在宏观工程师中，还可以加快凝胶的缩小

项目成果

岡野光夫、菊池明彦、青柳隆夫: "ゲルテクノロジー(医療用ハイドロゲル)" サイエンスフォーラム, 358 (1998)

Mitsuo Okano、Akihiko Kikuchi、Takao Aoyagi：“凝胶技术（医用水凝胶）”科学论坛，358（1998）

Y.Kaneko, S.Nakamura, K.Sakai, T.Aoyagi, A.Kikuchi, Y.Sakurai, T.Okano: "Rapid Deswelling Response of Poly(N-isopropylacrylamide)Hydrogels by the Formation of Water Release Chennels Using Poly(ethylene oxide)Graft Chains" Macromolecules. 31. 6099-6105 (19

Y.Kaneko、S.Nakamura、K.Sakai、T.Aoyagi、A.Kikuchi、Y.Sakurai、T.Okano：“通过使用聚（N-异丙基丙烯酰胺）形成水释放通道来实现聚（N-异丙基丙烯酰胺）水凝胶的快速消溶胀响应”

T.Okano, A.Kikuchi, T.Aoyagi: "Hydrogel for Clinical Use" Gel Technology (M.Abe, N.Murase, T.Suzuki, eds.Science Forum Inc.156-161 (1998)

T.Okano、A.Kikuchi、T.Aoyagi：“临床使用的水凝胶”凝胶技术（M.Abe、N.Murase、T.Suzuki，eds.Science Forum Inc.156-161（1998）

Y.Kaneko,S.Nakamura,K.Sakai,A.Kikuchi,T.Aoyagi,Y.Sakurai,T.Okano: "Deswelling mechanism for com-type grated poly(N-isopropylacrylamide) hydrogels woth rapid temperature responses" Polymer Gels and Networks. 印刷中.

Y. Kaneko、S. Nakamura、K. Sakai、A. Kikuchi、T. Aoyagi、Y. Sakurai、T. Okano：“具有快速温度响应的 com 型磨碎聚（N-异丙基丙烯酰胺）水凝胶的消溶胀机制” 聚合物凝胶和网络。

金子祐三、酒井清孝、菊池明彦、青柳隆夫、桜井靖久、岡野光夫: "温度応答性の速い高分子ゲルによる新しいパルス型薬物放出制御" 薬理と臨床. 7. 1295-1299 (1997)

Yuzo Kaneko、Kiyotaka Sakai、Akihiko Kikuchi、Takao Aoyagi、Yasuhisa Sakurai、Mitsuo Okano：“使用具有快速温度响应的聚合物凝胶的新型脉冲药物释放控制”药理学和临床研究 7. 1295-1299 (1997)。