Epidemiology and Control of Filariasis in Sri Lanla

斯里兰卡丝虫病的流行病学和控制

• 批准号: 08041184
• 负责人: KIMURA Eisaku
• 金额: $ 1.02万
• 依托单位: Aichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08041184/
• 关键词: Wuchereria bancrofti; diethylcarbamazine; Culex quinquefasciatus; permethrin; circulating antigen; elephantiasis; PCR; Sri Lanka

1.The situation of Wuchereria bancrofti infection in Matara(1) A total of 3384 people were examined. The microfilaria (mf) rate was 5.1%. There were 123 cases (5.1% of those examined) with filarial fever and 78 cases (3.3%) with elephantiasis/edema.(2) The positive rate of filarial circulating antigen was 20.7%, which was much higher than those obtained using conventional methods. The level of antigenemia was closely related to mf densities in the blood. Many 'antigen (+) and mf (-)' people were found. They constitute a new entity unknown to us before the antigenemia survey.2.The effect of annual single-dose diethylcarbamazine (DEC) treatment at 6 mg/kgThe single dose of DEC reduced mf count from the original 100% to 20% at 6 months, and to 27% at 12 months. If repeated yearly, the annual doses would reduce filarial transmission potential sharply.3.Studies on mosquito vectors in Matara(1) Mosquito (Culex quinquefasciatus) infection rate was 4.9%. Infected mosquitoes were collected through a year, indicating that tha filarial transmission occurs year-round.(2) Permethrin impregnated curtain was effective to reduce mosquito biting densities for the period of 22 weeks.4.Other activitiesSimple methods to determine serum concentration of anti-filarial drugs, and to measure circulating antigen level have been developed. PCR was successfully applied for the diagnosis of 2 species of lymphatic filariasis.

1.马塔拉（1）总共检查了3384人的Wuchereria Bancrofti感染的状况。微丝菌（MF）率为5.1％。有123例丝状发烧的病例（5.1％），有78例（3.3％）的象素/水肿。（2）丝状循环抗原的阳性率为20.7％，远高于使用常规方法获得的丝状抗原。抗原血症的水平与血液中的MF密度密切相关。发现了许多“抗原（+）和MF（ - ）”的人。它们构成了我们在抗血症调查之前未知的新实体。2。每年单剂量二乙基卡马嗪（DEC）治疗的影响6 mg/kg，单剂量的单剂量将DEC的单剂量从最初的100％降低到6个月，而在12个月（在12个月）降低到27％。如果每年重复，年剂量将急剧降低丝状传播潜力。在一年内收集了感染的蚊子，表明全年发生丝状传播。（2）氯菊酯浸渍的窗帘有效地减少22周的蚊子叮咬密度。 PCR成功地用于诊断2种淋巴丝虫病。

项目成果

Weerasooriya,M.V.: "Comparative efficacy of house curtains impregnated with permethrin,lambdacyhalothrin or bendiocarb against the vector of bancroftian filariasis,Culex quinquefasciantus Say in Matara." Transactions of the Royal Society of Tropical Medic

Weerasooriya，M.V.：“用氯菊酯、高效氯氟氰菊酯或苯虫威浸渍的窗帘对马塔拉班克罗夫特丝虫病媒介致倦库蚊的比较功效。”

Mitsui Y,Takamura N,Fujimaki Y,Yamaguchi T,Kitagawa T and Aoki Y: "Development of a competitive enzyme-linked immunosorbent assay for diethylcarbamazine." Tropical Medicine and International Health. 1. 528-534 (1996)

Mitsui Y、Takamura N、Fujimaki Y、Yamaguchi T、Kitakawa T 和 Aoki Y：“开发二乙基卡马嗪的竞争性酶联免疫吸附测定法。​​”

Weerasooriya MV.Munasinghe CS.Mudalige MPS et al.: "Comparative efficacy of house curtains impregnated with permethrin, lambdacyhalothrin or bendiocarb against the vector of bancroftian filariasis, Culex quinquefasciatus Say in Matara." Transactions of th

Weerasooriya MV.Munasinghe CS.Mudalige MPS 等人：“用氯菊酯、高效氯氟氰菊酯或苯虫威浸渍的窗帘对马塔拉班克罗夫特丝虫病媒介致倦库蚊的功效比较。”

Mitsui,Y.: "Simple and sensitive enzyme-linked immunosorbent assay for ivermectin" American Journal of Tropical Medicine and Hygiene. 54. 243-248 (1996)

Mitsui,Y.：“伊维菌素的简单而灵敏的酶联免疫吸附测定”美国热带医学和卫生杂志。

Kumura,E.: "Control of lymphatic filariasis by annual single-dose diethylcarbamazine treatments" Parasitology Today. 12. 240-244 (1996)

Kumura,E.：“通过每年单剂量二乙基卡马嗪治疗控制淋巴丝虫病”《今日寄生虫学》。