Compilation of the vibosome-related protein seguences and its application to the analysis on eukavyotic cellular evalution

病毒体相关蛋白序列的编译及其在真核细胞评价分析中的应用

基本信息

批准号：
07680742
负责人：
HASHIMOTO Tetsuo
金额：
$ 1.47万
依托单位：
THE INSTITUTE OF STATISTICAL MATHEMATICS
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

Large number of ribosomal protein (r-protein) sequences form various organisms have been accumulated up to now in the sequence databases. Although these data might have many informations on the evolution of the ribosomes, these are not well arranged in order because nomenclatures are various among different organisms, In this work we have systematically compiled the r-protein species, evolutionarily analyzing sequence similarities.On the basis of all the alignments constructed and phylogenetic analyzes carried out up to now, the evolutionary profile of r-proteins is emerging : (1) in no small number there are protein species that exist throughout the three primary kingdoms, (2) almost all the alignments show 'one to one' correlation to align regularly, that is irregular correlation such as internal transposition appears to be rarely found, (3) wide insertion/deletions and elongation in length are usually found in the comparisons among sequences from different primary kingdoms, while within a kingdom most of the evolutionary changes are amino acid replacements and minor insertion/deletions, (4) gene duplication events have occurred on several r-protein species in the various stages of eukaryotic evolution, (5) archaebactria do not show a monophyletic clade in no small number of r-protein species.On the other hand, we began to analyze the genes of ribosome-related molecules from amitochondriate protists, Glugea plecoglossi, Giardia lamblia and Trichomonas vaginalis to elucidate early evolution of eukaryotic ribosomes.

到目前为止，在序列数据库中已经积累了各种生物的核糖体蛋白（R蛋白）序列。 Although these data might have many informations on the evolution of the ribosomes, these are not well arranged in order because nomenclatures are various among different organisms, In this work we have systematically compiled the r-protein species, evolutionarily analyzing sequence similarities.On the basis of all the alignments constructed and phylogenetic analyzes carried out up to now, the evolutionary profile of r-proteins is emerging : (1) in no small number there （2）（2）几乎所有的对齐都显示“一对一”与定期对齐的相关性，例如内部换位等不规则的相关性，似乎很少发现，（3）在序列中，在序列中通常发现了较小的酸度，而在不同的原始王国中，范围内通常会发现王位的比较，而在王国中，王国中的次数很少，并且是王者的次数。插入/缺失，（4）基因重复事件发生在真核生物进化的各个阶段的几种R蛋白质物种上，（5）考古学在不少量的R蛋白质物种中没有显示出单属枝的枝状。 Lamblia和Trichomonas阴道，以阐明真核核糖体的早期演变。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Yamamoto,A.,Hashimoto,T.,et al.: "Phylogenetic position of mitochondrion-lacking protozoan,Trichomonas tenax,based on amino acid sequences of elongation factors 1α and 2" Journal of Molecular Evolution. 44. 98-105 (1997)

Yamamoto, A., Hashimoto, T. 等人：“基于延伸因子 1α 和 2 的氨基酸序列，缺乏线粒体的原生动物 Trichomonas tenax 的系统发育位置”，分子进化杂志 44. 98-105 (1997)。）

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

Kamaishi,T.,Hashimoto,T.,Nakamura,Y.,Masuda,Y.,Nakamura,F.,Okamoto,K.,Shimizu,M.and Hasegawa,M.: "Complete nucleotide sequences of the genes encoding translation elongation factors 1α and 2 from a microsporidian parasite,Glugea plecoglossi: implications f

Kamaishi, T.、Hashimoto, T.、Nakamura, Y.、Masuda, Y.、Nakamura, F.、Okamoto, K.、Shimizu, M. 和 Hasekawa, M.：“编码翻译延伸的基因的完整核苷酸序列来自微孢子虫寄生虫 Glugea plecoglossi 的因子 1α 和 2：影响 f