ONTOGENESIS AND ABERRATION OF HEART RATE VARIATION CONTROL IN RELATION TO INFLUENCING PHENOMENON IN THE HUMAN FETUS

心率变异控制的个体发生和畸变对人类胎儿的影响现象

• 批准号: 07457390
• 负责人: KOYANAGI Takashi
• 金额: $ 4.86万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457390/
• 关键词: Ontogenesis; Ultradian rhythm; Fetal heart rate variation; Active and quiet phases; Fetal stomach movement; Werner syndrome; Preeclampsia; Neutrophil degranulation; 先天性十二指腸閉鎖症; 超音波電子スキャン; 最小二乗メディアン法; active; quiet phase; 胃の蠕動運動; ウルトラディアンリズム

We summarized our study entitled the ontogenesis and aberration of heart rate (FHR) variation control in relation to influencing phenomenon in the human fetus.1.With regrd to the extent to which a given heart rate correlates with the following heart rate(s) at any gestational age, a linear decrement in "beat-delay" from 21 beats (mean) at 23-25 weeks to 11 beats at 28-29 weeks' gestation was noted, suggesting that the conduction system-oriented heart beat gradually comes under functional control of the autonomic nervous system as well as under possible regulation by the maturing medulla oblongata. From this point in gestation thereafter, there were no significant changes in "beat-delay", thereby implying that FHR variation becomes stabilized as a result of the control rendered by the more developed autonomic nervous system function.2.As for the rhythmic changes in fetal stomach movement (FSM), two different conditions stratified with statistical significance were present. Chronological … More ly, these changes appeared to cluster into the "active" and "quiet" phases at 29 weeks' gestation onwards. The underlying mechanism of this rhythmicity is likely to demonstrate the development of ultradian rhythm pertaining to the FSM,under control of the central nervous system function.3.A case of Werner syndrome characterized by premature aging was evident to have the potential risk of reproductive problems such as incompetent cervix, premature labor, intrauterine growth retardation and hypertensive disorder.4.The neutrophil degranulation observed in preeclampsia revealed a decrease in the total granule content retained in neutrophil. This suggests that in preeclampsia, a possible modification mechanism exists, specific in neutrophil degranulation and different from the N-formyl-methionyl-leucyl-phenylalanine-induced superoxide production system.Whether or not the maternal conditions described in the later two categories possibly contribute to FHR variation remain to be further elucidated. Less

我们总结了人类tus中的相关现象中心率（FHR）变化控制的个体发生和异常（FHR）的异常。1。与给定的心率与任何妊娠年龄的随后的心率相关的程度，在任何妇女年龄之间注意到23-25周的21个节拍（平均值）的线性减少到11个节拍的妊娠。以及成熟的髓质的不可能的调节。具有时间的意义。神经神经系统的功能。3.3。一种以前衰老的特征的Werndrome病例，这对于生殖问题的潜在风险，例如不称职的子宫颈和高血压障碍。4。中性粒细胞脱粒，在前子粒细胞中观察到中性粒细胞中的中性粒细胞。可能的修饰机制存在于中性粒细胞脱粒中，并且与N-甲基甲基苯丙氨酸诱导的超氧化物的原子不同。是否在后来的两个类别中描述的母体条件可能会导致TOH R变化仍然较少

项目成果

M.Ogawa: "Pregnancy complicated with Werner syndrome." Obstetrics & Gynecology. 88. 722. (1996)

M.Okawa：“怀孕并发维尔纳综合征。”

H.Nakano: "Fetal heart rate variation describes a long-term developmental course of the human fetus, normal and abnormal." In C.Yabes-Almirante and M.B.de Luna eds.Increasingly Safe and Successful Pregnancies. Amsterdam : Elsevier. 199-206 (1996)

H.Nakano：“胎心率变化描述了人类胎儿的长期发育过程，正常和异常。”

H.Nakano: "In C.Yabes-Almirante and M.B.de Luna eds.Increasingly Safe and Successful Pregnancies.Amsterdam:Elsevier." Fetal heart rate variation describes a long-term developmental course of the human fetus,normal and abnormal., 199-206. (1996)

H.Nakano：“C.Yabes-Almirante 和 M.B.de Luna 编辑的《越来越安全和成功的怀孕》。阿姆斯特丹：Elsevier。”

Ogawa M: "Pregnancy complicated by Werner syndrome." Obstetrics and Gynecology. 722 (1996)

小川 M：“怀孕并发维尔纳综合征。”

N.Horimoto: "Developmental changes in arachidonic acid potentiation of NMDA currents in cortical neurones" NeuroReport. 7. 2463-2467 (1996)

N.Horimoto：“皮质神经元中 NMDA 电流的花生四烯酸增强的发育变化”NeuroReport。