Development of a system for quantitative diagnosis of myocardial infarction and atherosclerosis based on non-invasive measurement of small vibrations on the heart wall or arterial walls and their analysis

基于心壁或动脉壁微小振动的无创测量及其分析的心肌梗塞和动脉粥样硬化定量诊断系统的开发

• 批准号: 04555092
• 负责人: KANAI Hiroshi
• 金额: $ 1.92万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04555092/
• 关键词: atherosclerosis; myocardial infarction; non-invasive measurement; pulse wave velocity; elastic characteristics; ultrasonic Doppler; spectrum analysis; small vibration measurement; 脈波伝搬特性; 循環器疾患; 超音波計測; 振動スペクトル; 局所的弾性特性

In this research, we have developed a new method to measure local pulse wave velocity, which is an index of the hardness in the range of several millimeters on the aortic wall. In the standard method, the pulse wave velocity (PWV) is obtained from the difference in arrival time of pressure waves propagating from the carotid artery to the femoral artery. In this method, the measurable points are limited to those where the aorta exists near the skin surface and the distance between such points is considerable long, i.e., several hundred millimeters. It is important for early diagnosis, however, to measure the local hardness of the surface of the arterial wall. To increase the spatial resolution, it is necessary to measure vibrations due to pulse waves with frequency components up to about 50 Hz.Therefore, we have developed a new system to noninvasively measure small vibration signals on the heart wall or the aortic wall from the surface of the skin based on the ultrasonic Doppler effect. … More By this system, small vibrations with amplitudes of 10 - 100 mum on the motion due to heart beat with the large amplitude of 10 mm are successfully detected in the frequency range up to 1 kHz continuously for more than ten beat periods from the chest.This research also developed a new method for obtaining local PWV by simultaneously measuring small vibrations at two points on the surface of the tube wall and the aortic wall. By the developed method, high spatial resolution, which is necessary in the evaluation of local hardness, is attained. By comparing the static experiments and dynamic experiments using a silicon tube, it is confirmed that the local hardness (Young's modulus) of the vessel wall is also evaluated with high spatial resolution.By applying the developed system and the method to in vivo experiments, the PWV of the vibration wave transmitted between the two points on the aortic wall is obtained even for the aortic wall near the aortic valve. The distance between the two points is about several millimeters. The local elasticity (Young's modulus) is also evaluated for each measurement point. Thus, the developed system will be effective for local evaluation of the hardness on the aortic wall. Less

在这项研究中，我们开发了一种测量局部脉搏波速度的新方法，它是主动脉壁几毫米范围内的硬度指标。在标准方法中，脉搏波速度（PWV）是从主动脉壁上获得的。压力波从颈动脉传播到股动脉的到达时间的差异在这种方法中，可测量的点仅限于主动脉靠近皮肤表面的点，并且这些点之间的距离相当长，然而，测量动脉壁表面的局部硬度对于早期诊断很重要，为了提高空间分辨率，有必要测量频率成分高达约100的脉搏波引起的振动。 50 Hz。因此，我们开发了一种新系统，基于超声波多普勒效应，从皮肤表面无创地测量心壁或主动脉壁上的小振动信号……更多通过该系统，可以测量小振动。在高达 1 kHz 的频率范围内，成功地从胸部连续检测到 10 多个心跳周期内的振幅为 10 - 100 mum 的心跳运动，振幅为 10 mm。该研究还开发了一种新方法通过同时测量管壁和主动脉壁表面两点的小振动来获得局部 PWV 通过比较静态，获得了评估局部硬度所需的高空间分辨率。实验通过使用硅管的动态实验，证实了血管壁的局部硬度（杨氏模量）也可以以高空间分辨率进行评估。通过将开发的系统和方法应用于体内实验，振动波的 PWV即使对于主动脉瓣附近的主动脉壁，也能获得主动脉壁上两点之间传输的能量。每次测量也会评估两点之间的距离约几毫米。因此，所开发的系统将有效地评估主动脉壁的硬度。

项目成果

Hiroaki Sato, Hiroshi Kanai, Noriyoshi Chubachi: "Measurement of Small Vibration on Heart Wall by Tracking Cardiac Motion using Dynamic Programming" The Journal of the Acoustical Society of Japan. Vol.50, No.1. 11-21 (1994)

Hiroaki Sato、Hiroshi Kanai、Noriyoshi Chubachi：“使用动态编程跟踪心脏运动来测量心壁上的小振动”日本声学学会杂志。

金井 浩,中鉢 憲賢: "動脈硬化の早期診断を目指した動脈壁上の微小振動伝搬特性の計測" 日本超音波医学会誌. 20. (1993)

Hiroshi Kanai、Kenken Chubachi：“测量动脉壁上的微小振动传播特性以早期诊断动脉硬化”，日本医学超声学会杂志 20。（1993 年）

今井 正樹,金井 浩 中鉢 憲賢,小黒 瞬 鈴木 英男: "異なる周波数帯域成分間の相関性の定量的計測法" 日本音響学会誌. 49. (1993)

Masaki Imai、Hiroshi Kanai、Kenken Chubachi、Shun Oguro 和 Hideo Suzuki：“不同频带分量之间相关性的定量测量方法”，日本声学学会杂志 49。（1993 年）。

Hiroshi Kanai, Toyohiro Hori, Noriyoshi Chubachi, and Takahiko Ono: "Delayd Block Transfer Function and its Application to Accurate Estimation of Transfer Function" IEEE Transactions on Signal Processing. Vol.41, No.7(in press). (1994)

Hiroshi Kanai、Toyohiro Hori、Noriyoshi Chubachi 和 Takahiko Ono：“延迟块传递函数及其在传递函数精确估计中的应用”IEEE 信号处理汇刊。

朴茂薫,金井浩,中鉢憲賢: "“超音波ドプラ法による加振時の骨の曲げ振動伝搬速度の計測"" 日本音響学会誌. 50. 103-109 (1994)

Shigekun Park、Hiroshi Kanai、Kenken Chubachi：“使用超声多普勒方法测量激励期间骨骼中弯曲振动的传播速度”日本声学学会杂志 50. 103-109 (1994)。