Experimental Studies of Influencing Agents to Neuromuscular Blocking Effects

影响神经肌肉阻滞作用的药物的实验研究

• 批准号: 03670736
• 负责人: SUZUKI Hajime
• 金额: $ 1.15万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670736/
• 关键词: Neuromuscular block; magnesium ion; muscle relaxants; Rocuronium; Calcium channel blockers; Diltiazem; Evoked electromyography; alpha-Bungarotoxin; パンクロニウム; Rocuronium; Vecuronium; 神経筋庶断; 複合筋活動電位面複曲線

[Aim of Investigation]The studies were aimed to evaluate electrophysiologically neuromuscular blocking mechanisms of some agents which are using to clinical anesthesia.[Methods]Compound action potentials (CAPs) which were derived from gastrocunemius muscles of cats by electrical stimulation of sciatic nerves were induced. Changes of amplitudes of CAPS, recovery curves (RCs) and tranin-of-four ratios (TOFRs) which were obtained from changing mode of stimulations were estimated for evaluation of their blocking effects.[Results]1. Neuromuscular blocks which were depended on serum [Mg^<2+>] were observed, and some evidences which were suggested that the blocks were caused from inhibition of transmitter release from motor nerves could be found.2. When the blocking effects by non-depolarizing relaxants were compared to that by Mg^<2+>, it was reconfirmed that the relaxants may have some inhibiting effects to motor nerve terminals.3. Rocuronium, a newly developed relaxant, produced non-depolarizing block, and its inhiditing effect to motor nerve terminals was similar as to be found in vecuronium.4. Diltiazem, a calcium channel blocker, showed a slight neuromuscular blocking effect, however, the effect was considered to be ignored ievel.

[研究目的]本研究旨在评价一些用于临床麻醉的药物的电生理神经肌肉阻滞机制。[方法]通过电刺激坐骨神经诱导猫腓肠肌产生复合动作电位(CAP) 。估计改变刺激模式时获得的CAPS幅度、恢复曲线(RCs)和四轮比值(TOFRs)的变化，以评价其阻断效果。[结果]1．观察到依赖于血清[Mg^2+]的神经肌肉阻滞，并发现了一些证据表明该阻滞是由于运动神经递质释放受到抑制而引起的。2．将非去极化弛豫药与Mg^2+的阻滞作用进行比较，再次证实弛豫药可能对运动神经末梢有一定的抑制作用。 3．罗库溴铵是一种新开发的松弛剂，产生非去极化阻滞，其对运动神经末梢的抑制作用与维库溴铵相似。 4．地尔硫卓是一种钙通道阻滞剂，显示出轻微的神经肌肉阻滞作用，但该作用被认为可以忽略不计。

项目成果

Hidemori SHIRAISHI: "Study of neuromuscular transmission with evoked electromyography--11. Comparison between blocks by magnesium and by pancuronium (English Abstract)" MASUI 43 (4). (Accepted to publish). (1993)

Hidemori SHIRAISHI：“用诱发肌电图研究神经肌肉传递--11。镁阻滞剂和泮库溴铵阻滞剂的比较（英文摘要）”MASUI 43 (4)。

Hidemori Shiraishi, et al: "Fading Resporses in the Euoked FMG after Rocuronium in Cats" Canadian Jomnal of Anaesthesia. 39. 1099-1104 (1992)

Hidemori Shiraishi 等人：“猫罗库溴铵后 Euoked FMG 中的反应消失”加拿大麻醉杂志。