Study on development of new bactericidal-biocompatible material for conserving infected pulp.

新型杀菌生物相容性牙髓保存材料的开发研究

基本信息

批准号：
03404055
负责人：
IWAKU Masaaki
金额：
$ 20.42万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1994
项目状态：
已结题

项目摘要

This study was projected for developing the most effective new bactericidal-biocompatible material to conserve the infected pulp tissue.Following results were obtained :1. A mixture of Ciprofloxacin, Metronidazole and Cefaclor showed the complete bactericidal efficacy against all of the bacteria in the infected pulp tissue.2. The antibacterial mechanism of metronidazole was revealed the investigation of the metabolism of phenylalanine and leucine of anaerobic bacteria.3. alpha-tricalcium phosphate (alpha-TCP) showed the superior biocompatibility as the direct capping material on the histopathological study using adult monkeys.4. The histopathological study showed that alpha-TCP containing mixed antibacterial drugs effectively disinfected the bacterially contaminated pulpal lesions of adult monkeys without destroying any of the sound pulp tissue and formed the hard tissue barrier covering the exposed pulpal surface.5. alpha-TCP containing mixed antibacterial drugs completely disinfected human caries lesions in vitro and in situ studies.6. In the in vivo study of the volunteer peoples, artificially exposed pulp tissue was convered by the hard tissue barrier formation without destroying any of the sound pulp tissue, when alpha-TCP containing mixed antibacterial drugs was applied on the exposed pulp tissue.7. In the clinical study of the volunteer patients, almost cases of the infected pulp, especially young, has been kept without any of the pulpectomy or pulpotomy by the application of the mixed antibacterial drugs added to alpha-TCP and covered with time by the hard tissue barrier.8. This work is now in progress.

这项研究预计是为了开发最有效的新杀菌生物兼容材料以保护感染的纸浆组织。环丙沙星，甲硝唑和头孢克拉的混合物表现出针对感染纸浆组织中所有细菌的完全杀菌疗效。2。甲硝唑的抗菌机制揭示了对厌氧细菌的苯丙氨酸和亮氨酸的代谢的研究。3。磷酸α-磷酸盐（α-TCP）在组织病理学研究中使用成年猴子在组织病理学研究中表现出优异的生物相容性。4。组织病理学研究表明，含有混合抗菌药物的α-TCP有效地消毒了成年猴子的细菌污染的牙髓病变，而不会破坏任何声音浆组织，并形成覆盖暴露的牙髓表面的硬组织屏障5。含有混合抗菌药物的α-TCP在体外和原位研究中完全消毒了人类龋齿病变。6。在志愿者的体内研究中，当将含有混合抗菌药物的α-TCP施加在暴露的果肉组织上时，通过硬组织屏障的形成人为地裸露的果肉组织在不破坏任何声浆组织的情况下通过硬组织屏障的形成转化。7。在志愿者患者的临床研究中，通过在α-TCP中添加的混合抗菌药物的应用，几乎没有任何肺炎或肺切开术的病例，尤其是年轻的果肉，尤其是年轻的果肉，并被硬组织屏障的时间覆盖。8。这项工作正在进行中。