Epidemiology of Budd-Chiari syndrome and its treatment by IVR

布加综合征的流行病学及IVR治疗

• 批准号: 03045025
• 负责人: KANEKO Masao
• 金额: $ 3.58万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03045025/
• 关键词: Budd-Chiari syndrome (BCS); Epidemiology; Dietary habit; BCS animal model; Laminaria constrictor; Interventional Radiology (IVR); Percutaneous transluminal angioplasty (PTA); Expandable metallic stent (EMS); Budd-Chiari症候群; Balloon angioplasty

Imaging diagnosis of Budd-Chiari Syndrome (BCS) being easier and more accurate by the definite criteria of the disease, however, BCS is rather rare in Japan statistically. In this study epidemiological investigation was performed by the co-operation of Chinese hospitals, where more BCS patients were available. Fifty-four patients (33 males, 21 females) of BCS over 15 years of age were subjected to study for the symptoms and laboratory findings as well as the recent dietary habit of the BCS patients, compared with the 14 control patients of each circulatory and digestive disease in accordance with the age and sex.The average onset ages were 30.3 years for males and 18.7 for females. Sex ratio was 1.57 ; more male than female. There was no characteristic family history nor past history. Abdominal distension and edema in the lower extremities were found in more than 75% of male and female patients. In males, melena, hematemesis and abdominal pain were frequently observed and abdominal pain and anorexia in females. It was noted that serum albumin was low and many patients had anemia and low platelet counts. More than 50% of the patients had enlarged liver, splenomegaly, esophageal varicies and dilated tortuous veins on the skin of abdominal and/or chest region. Smoking was not related to the disease. As for diet, BCS patients had more frequently potatoes and less frequently dried bean paste, rice in the morning, pork, vegetables and pear than 2 control groups. For fundamental study, experimental rat BCS model was developed by the use of laminaria constrictor.Thirty-two patients of BCS were treated by interventional radiology (IVR). The initial treatment of 21 cases was percutaneous transluminal angioplasty (PTA)) only and later 11 cases were treated by expandable metallic stent (EMS) from the beginning. Re-stenosis was treated by PTA and/or EMS. The long term follow-up encourages the good outcome of IVR on BCS.

通过疾病的明确标准，对Budd-Chiari综合征（BCS）的成像诊断更容易，更准确，但是，BCS在日本统计学上很少见。在这项研究中，通过中国医院的合作进行了流行病学研究，那里有更多的BCS患者可用。 15岁以上的BC的54例患者（33名男性，21名女性）受到研究的症状和实验室发现以及BCS患者最近饮食习惯的研究，与年龄和性别的每种循环系统和消化疾病的14例患者相比，平均年龄为30.3岁。性别比为1.57；男性比女性更多。没有特色的家族史也没有过去的历史。超过75％的男性和女性患者发现下肢的腹部扩张和水肿。在男性中，经常观察到梅雷娜，血液和腹痛以及女性的腹痛和厌食症。值得注意的是，血清白蛋白较低，许多患者患有贫血和低血小板计数。超过50％的患者在腹部和/或胸部区域的皮肤上肝脏肿大，脾肿大，食管静脉曲张和曲折静脉扩张。吸烟与疾病无关。至于饮食，BCS患者的土豆频率更高，早晨干米饭，猪肉，蔬菜和梨的频率较低，而不是2个对照组。对于基本研究，实验性大鼠BCS模型是通过使用laminaria coldictor开发的。通过介入放射学（IVR）治疗BC的三十二名患者。最初的21例病例治疗仅是经皮易流血管成形术（PTA），从一开始就通过可扩展的金属支架（EMS）处理11例。重新延伸作用是PTA和/或EMS治疗的。长期随访鼓励了BCS IVR的良好结果。

项目成果

岡和田 健敏,高橋 元一郎,宮崎 洋二郎,加藤 良一,加藤 俊彦,金子 昌生: "門脈内腫瘍塞栓に対するGianturco型expandable metallic stentの留置 -初期臨床経験-" 日本医学放射線学会雑誌. 52. 1599-1601 (1992)

Taketoshi Okawada、Motoichiro Takahashi、Yojiro Miyazaki、Ryoichi Kato、Toshihiko Kato、Masao Kaneko：“插入 Gianturco 型可扩张金属支架用于门静脉内肿瘤栓塞 - 初步临床经验 -” 日本医学放射学会杂志 52。 1599-1601。 (1992)

Ke Xu,Ming-Jun Han,Han-gue Zhang,Fang-xian He,Jing-rung Chang,Chang-lung Wang,Masao Kaneko,Motoichiro Takahashi,Taketoshi Okawada: "Clinical observation of Budd-Chiari syndrome treated by balloon angio-plasty(Report of 24 cases)(in Chinese)" Chinese Journ

徐科、韩明君、张汉歌、何芳贤、张景荣、王长龙、金子正夫、高桥本一郎、大川田刚俊：“球囊血管扩张术治疗布加综合征的临床观察”

高橋 元一郎,岡和田 健敏,加藤 良一,望月 隆男,大川 賀久,金子 昌生,徐 克,張 漢国,何 芳顕: "Rosch-Uchida Liver Access Setを用いたTIPSS(Transjugular Intrahepetic portosystemic Stent Shunt) -その妥当性に関するCTによる分析と臨床応用-" 日本医学放射線学会雑誌. 52. 1692-1694 (1992)

Genichiro Takahashi、Taketoshi Okawada、Ryoichi Kato、Takao Mochizuki、Kahisa Okawa、Masao Kaneko、Ke Xu、Hanguo Zhu、Fangxian He：“使用 Rosch-Uchida 肝脏通路套件的 TIPSS（经颈静脉肝内门体分流术） - 使用 CT 和 CT 进行有效性分析临床应用-》日本医学放射学会杂志. 52. 1692-1694 (1992)