Study of Pathogenesis in Dysphagia

吞咽困难发病机制的研究

• 批准号: 02670767
• 负责人: OKAMURA Hiroshi
• 金额: $ 1.34万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670767/
• 关键词: deglutition; dysphagia; fluorography; swallowing pressure; esophageal orifice; cricopharyngeal muscle; geriatrics; swallowing reflex; 嚥下プログラム; 嚥下圧曲線; 咽頭・食道透視; 固型造影剤; 筋電図

In this research project, normal and pathological swallowing function was evaluated through multidimensional analyses of deglutition.Investigation of Swallowing Mechanisms by Pharyngo-esophageal FluorographyThe following findings were often observed in geriatric group ; laryngeal penetration and disorder of movement of epiglottis in using liquid contrast medium and retention of bolus in the valleculla and pharyngeal splitting deglutition in using solid contrast medium. The same findings were also observed in the group with a sensation of difficulty in swallowing. These results suggest that propelling power of bolus and swallowing reflectory mechanism may be distorted in geriatric group and at the initial stage of dysphagia.Investigation of Swallowing Mechanisms by Measurements of Swallowing Pressure and Electromyographic RecordingsThe cricopharyngeal muscle mainly regulated the resting tone of the esophageal orifice and was innervated by the pharyngo-esophageal nerve unilaterally. The … More normal critical ranges of the swallowing pressure at the velopharyngeal, hypopharyngeal and cervico-esophageal regions were determined through observation of 30 normal adults. From these ranges, the classification of swallowing pressure curve which consists of 5 types was defined. The normal conduction curve of swallowing pressure was an S-like figure and this curve could visualize normal or abnormal pattern of conduction of swallowing pressure. The relaxation of the esophageal orifice started at the pharyngeal end. Therefore, to investigate the relaxation of the esophageal orifice in swallowing, it was recommended that the intraluminal pressure should be measured at the pharyngeal end. The critical ranges of the time and duration of the relaxation was also determined.Multi-dimensional Analyses of Pathogenesis of DysphogiaMulti-dimensional analyses of pathogenesis of dysphagia was investigated in 130 patients with dysphagia. The application of solid bolus for fluorography is a useful method for detecting the loss of swallowing reflex and the decrease of propelling power of bolus. The program of swallowing in the central nervous system can be clarified by the conduction curve of swallowing pressure, and the propelling power of bolus by the classification of swallowing pressure curve. Moreover, the relaxing mechanisms of the esophageal orifice are diagnosed by the measurement of the intraluminal pressure at the pharyngeal end. Less

在这项研究项目中，通过多种多样的吞咽功能。对比培养基。由pearyngo-posophegeal神经支配，横向……吞咽的更为正常的临界范围，在静脉咽喉，下刺和宫颈癌的范围ure的类型是类似的，这可以可视化吞咽压力的正常或异常还确定了放松的时间和持续时间。通过吞咽压力曲线的分类，推注的能力是通过对成对末端的Ntraluminal disture的测量来诊断出的

项目成果

丘村 煕,森 敏裕,稲木 匠子: "Hypopharyngeal Stricture (in Recent Advances in BronchoーEsophagology (edーby Inoue T))" Excerpta Medica, 600(227-232) (1990)

Hiro Okamura、Toshihiro Mori、Takuko Inagi：“下咽狭窄（支气管食管学的最新进展（由 Inoue T 编辑））” Excerpta Medica，600(227-232) (1990)

稲木 匠子,丘村 煕,森 敏裕: "Radiographic Evaluation of Pharyngeal Swallowing (in Otorhinolaryngology.Head and Neck Sargery,od.by Sacritan,T.)" Kugler publication, 3206(3011-3013) (1991)

Takuko Inagi、Hiro Okamura、Toshihiro Mori：“咽部吞咽的放射学评估（在 Otorhinolaryngology.Head and Neck Sargery，od.Sacritan,T.）” Kugler 出版物，3206(3011-3013) (1991)

Hiroshi Okamura Toshihiro Mori: "Surgical treatment of Functional Dysphagia" J Clin Exper Med. 154, No. 11. 11687-690 (1990)

Hiroshi Okamura Toshihiro Mori：“功能性吞咽困难的手术治疗”J Clin Exper Med。

Hiroshi Okamura Shoko Inaki Kouji Fukui Ryiuchi Aibara: "Pharyngeal Swallowing Function in the Elderly -Videofluoroscopic Observations-" J Jpn Bronchoesophagol Soc. 42, No. 2. 116-120 (1991)

冈村浩 翔子 稻城晃司 福井龙内 相原龙一：“老年人的咽部吞咽功能 - 电视透视观察 -” J Jpn Bronchoesophagol Soc。

丘村 煕,森 敏裕,相原 隆一,稲木 匠子,福井 康二,河北 誠二: "嚥下機構に関する実験的研究ー輸状咽頭筋の神経支配様式ー" 喉頭. 3. 97-102 (1991)

Hei Okamura、Toshihiro Mori、Ryuichi Aihara、Takuko Inagi、Koji Fukui、Seiji Kawakita：“吞咽机制的实验研究 - 咽部肌肉横向的神经支配模式” Larynx. 3. 97-102 (1991)