Ontogenetic development of neural control of the heart rate in the human fetus quantitatively assessed using a probability matrix.

使用概率矩阵定量评估人类胎儿心率神经控制的个体发育。

基本信息

批准号：
01570935
负责人：
KOYANAGI Takashi
金额：
$ 1.41万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

项目摘要

For the past 3 years, we quantitatively analyzed, using a probability matrix, the age-related fetal heart rate changes in the fetuses with hydrocephalus and anencephalous as well as the normal fetuses.1. Analyzed was the age-related characteristics of FHR variation in normal fetuses from 20 to 41 weeks' gestation, using the "congruence rate" between the standard matrix constructed from the original whole data in each 2 consecutive gestational age and the matrix produced from a small sample of FIIR data randomly selected from the original data set, as a parameter. The minimum number of FHR beats necessary to get a "congruence rate" of 90% for the standard probability matrix was 2700 beats at 27-28 weeks' gestation, gradually increasing up to about 6000 beats at 34-35 weeks' gestation. Two statistically significant critical points were found to be at 28-29 weeks' and at 34-35 weeks' gestation. These findings indicate that there were 3 different characteristics of FHR variation pertaining … More to the mechanism. of PIIR control throughout the gestational periods studied.2. Refering to the standard probability matrix for the corresponding gestational week, the age-related differences in fetal heart rate change in anencephalic or hydrocephalic fetuses was evaluated, using the 'incongruence rate" as a parameter, representing the difference between the standard matrix and the subjected matrix. In hydrocephalic fetuses, the -incongruence rate- remained within the normal range, between 11.8 and 30.6% at 31-39 weeks' gestation. On the contrary, in anencephalic fetuses, the "incongruence rate" increased, with advance in gestation, from 15.9-40.6% at 24 weeks' gestation to 36.5-45.3% at 34 weeks' gestation. and the values were beyond the normal range from 31 weeks' gestation onwards. Combining these results with autopsy findings, these suggest that the central nervous system, cephalate to the medulla, begins to play a substantial role in the control of fetal heart rate changes, at least, from 31 weeks' gestation onwards. Less

在过去的3年中，我们使用与年龄相关的胎儿心率变化，与正常胎儿相关的胎儿变化。1。几周的妊娠，使用“在连续2个妊娠年龄的原始整体数据中均制成的标准与从原始数据集随机选择的一小部分fiir数据产生的矩阵，作为参数。FHRBEATS的最小数量对于标准概率矩阵的90％是27-28的妊娠，在妊娠34-35周时逐渐增加了大约6000次。 FHR的变化与妊娠期的胎儿相关的妊娠期。 ND在31-39周的妊娠期。这些结果与尸检结果相结合，表明中央神经系统从31周开始