Analysis of the Fetal Functional Maturity

胎儿功能成熟度分析

• 批准号: 63570783
• 负责人: HARA Kazuhiro
• 金额: $ 0.9万
• 依托单位: Kagawa Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570783/
• 关键词: fetal behavior; eye movement; amniotic fluid volume; fetal abnormality

In the management of the high-risk pregnancy, the evaluation of the fetal functional maturity is most important. Recently, so called "fetal behavior" has been regarded as the most reliable information.In this study, the quantitative analysis of fetal behavior concerning fetal movements, fetal heart rate, fetal reaction to sound stimulation, fetal breathing movement, fetal eye movement in relation to REM and non-REM sleep state were carried out. And effects of drug on the fetal nervous system were also analyzed.In the complicated cases, such as EPH and IUGR, fetal nervous functions were clearly suppressed. (1) The number and strength of the fetal movement were suppressed, (2) the number of acceleration at fetal movement were also suppressed, (3) the inclination of acceleration reduced, however the the height of acceleration remained unchanged, (4) the reaction to the sound stimulation was suppressed in the complicated cases, (5) the fetal breathing movement diminished clearly, (6) The fetal eye movement was also suppressed. Concerning the effect of drug to the fetus, fetal movement and FHR accerelation were accurately diminished by the administration of chlorpromazine or haloperidol even in normal serum concentration. On the other hand, anticonvulsant (Phenytoin and Phenobarbital) showed no depressive effect on the fetus under the normal serum drug concentration.

在高危妊娠的管理中，对胎儿功能成熟的评估最为重要。最近，所谓的“胎儿行为”被视为最可靠的信息。在这项研究中，对胎儿运动，胎儿心脏速率，对声音刺激的胎儿反应，胎儿呼吸运动，与REM相关的胎儿眼运动和非REM睡眠状态的定量分析。还分析了药物对胎儿神经系统的影响。 （1）抑制胎儿运动的数量和强度，（2）胎儿运动时的加速度数也被抑制，（3）加速度的倾向降低，但是加速度的高度保持不变，（4）在复杂的情况下，对痛苦的反应抑制了胎儿呼吸的移动，（5）受到抑制的移动，（5）fteral dise the Fittal the Fettal，（6）fteral the Fettal，（6）。关于药物对胎儿的影响，即使在正常的血清浓度下，氯丙嗪或氟哌啶醇也可以准确地减少胎儿运动和FHR加速度。另一方面，在正常的血清药物浓度下，抗惊厥药（苯妥英钠和苯巴比妥）对胎儿没有抑郁作用。

项目成果

K. Hara, T. Yanagihara, T. Jimbo: "Diagnosis of fetal disease and its prognosis" The Japanese Journal of Perinatal Care. 86. 816-822 (1989)

K. Hara、T. Yanagihara、T. Jimbo：“胎儿疾病的诊断及其预后”日本围产期护理杂志。

K. Hara, T. Yanagihara, T. Jimbo: "Ultrasound diagnosis of fetal development" Obstetrical and Gynecological Therapy. 57 (5). 512-527 (1988)

K. Hara、T. Yanagihara、T. Jimbo：《胎儿发育的超声诊断》妇产科治疗。

K. Hara, T. Yanagihara, T. Jimbo: "Intrauterine therapy of the fetal urinary tract obstruction." Obstetrical and Gynecological Therapy. 58 (5). 569-573 (1989)

K. Hara、T. Yanagihara、T. Jimbo：“胎儿尿路梗阻的宫内治疗。”

K. Hara: "Psychiatric and Nervous Disorders" Acta Obstetrica et Gynaecologica Japonica. 42 (8). 847-853 (1990)

K. Hara：“精神和神经障碍”Acta Obstetrica et Gynaecologica Japonica。

原 量宏,柳原 敏宏,神保 利春: "胎児尿路閉塞症の胎内治療" 産婦人科治療. 58(5). 569-573 (1989)

Yasuhiro Hara、Toshihiro Yanagihara、Toshiharu Jimbo：“胎儿尿路梗阻的子宫内治疗”妇产科治疗 58（5）569-573（1989）。