CLINICAL AND EXPERIMENTAL STUDIES ON THE MAINTENANCE OF SUFFICIENT HEPATIC CIRCULATION WITH ARTERIAL BLOOD DURING THE TEMPORARY OCCLUSION OF THE HILAR HEPATIC CIRCULATION.

暂时阻塞肝门肝循环期间用动脉血维持充分肝循环的临床和实验研究。

基本信息

批准号：
63570638
负责人：
HAMAZAKI Keisuke
金额：
$ 1.34万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

1.Experimental study in mongrel dogs: This study was performed to clarify the safe range of the blood flow volume to maintain the liver function, structure and systemic circulation as possible as normal under the condition of total hilar clamping when the hepatic circulation was supplied only through the extracorporeal catheter bypass from the artery to the hepatic portal vein in flow control.(1)In the study of the energy metabolism of the liver during the bypass circulation, the lowest limit of the arterial blood inflow volume tl maintain the hepatic function was confirmed to be in the range between 10% to 25% of the normal total hepatic blood flow volume.(2)In the study of the morphology of the liver after the bypass circulation for 2 hours, the lowest limit of the arterial blood inflow volume to maintain the hepatic structure normal was confirmed to be in the range between 10% to 25% of the normal total hepatic blood flow volume.The highest limit of that was confirmed to be in the range between 50% to 75% of the normal total hepatic blood flow volume.(3)In the study of the systemic hemodynamics during the bypass circulation, the safe flow rate of bypass circulation ranged from 25% to 75% of the normal total hepatic blood flow volume.2.Clinical studyThis double catheter bypass method was devised to perform block resection of the hepatoduodenal ligament in cases of the carcinoma of the bile duct and head of the pancreas. In the study of 20 clinical cases, this method was confirmed to be safe from the view point of the systemic hemodynamic and liver function tests.

1.经验杂种犬的实验性研究：进行了这项研究，以阐明血液流量的安全范围，以在总的肺夹层状态下，在总肺夹具的状态下，在肝外绕过肝外旁路的肝外静脉循环中以肝静脉的流量控制在流量控制中（1）在流量中，在流量中，在流量中，肝外绕过肝循环时，尽可能正常。动脉血液流入体积TL维持的最低极限确认肝功能在正常总血流量的正常总血流量的10％至25％之间。（2）在研究旁路循环后肝脏形态2小时的研究中，在动脉血液易流量的最高范围是正常水平的范围25％的范围为25％的范围25％，均为5％的范围。确认的限制在正常总血流量量的50％至75％之间。（3）在旁路循环期间全身性血流动力学的研究中，旁路循环的安全流量范围为25％到75％的肝血流量的正常血流量的范围为正常血液流量的正常水平。胆管癌和胰腺头。在对20例临床病例的研究中，从系统性血流动力学和肝功能测试的角度来确认该方法可以安全。