Changes of functions of polymorphonuclear leukocyte after surgery for carcinoma of GI tract.

胃肠道癌术后多形核白细胞功能的变化。

• 批准号: 63570587
• 负责人: KITAMURA Michihiko
• 金额: $ 1.28万
• 依托单位: Akita University (1989)Tohoku University (1988)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570587/
• 关键词: respiratory failure after surgery for carcinoma of GI tract; superoxide anion production of polymorphonuclear leukocyte(PMN); content of lysozome of PMN; complement receptors of PMN; serum complement; serum PMN elastase; 消化器癌術後の呼吸不全; 多核白血球の活性酸素産性能

Superoxide anion production of polymorphonuclear Ieukocyte(PMN) after surgery for carcinoma of the esophagus increased significantly and reached to a peak level on 3rd-postoperative-day. Values of serum PMN elastase also increased after surgery and contents of lysozomal enzyme decreased at the same phase. Serum complement values(C3a) increased and there was statistically significant relation between the change of values of superoxide anion production and that of serum C3a. PMN complement receptors also increased. Respiratory-M-index, calculated for estimation of hypoxemia,increased significantly after surgery and reached to a peak level on 3rd-postoperative-day. There was statistically significant relation between the change of values of respiratory-M-index and that of superoxide anion production of PMN. It is concluded that hypoxemia after surgery for carcinoma of GI tract can be caused by activation of functions of PMN such as superoxide anion production and lysozomal enzyme release.

食管癌后，多形核IEUKOCYTE（PMN）的超氧化物阴离子的产生显着增加，并在第三阶段术日达到峰值水平。血清PMN弹性蛋白酶的值在手术后也增加，溶菌酶酶的含量在同一阶段降低。血清补体值（C3a）增加，超氧化阴离子产生的变化与血清C3a的变化之间存在统计学上的显着关系。 PMN补体受体也增加了。用于估计低氧血症的呼吸道-M指数在手术后显着增加，并在第三阶段的日期达到峰值水平。呼吸道-M指数值的变化与PMN的超氧化物阴离子产生的变化之间存在统计学意义。结论是，胃肠道癌后缺氧血症可能是由PMN功能（例如超氧化物阴离子产生和溶菌酶释放）的激活引起的。

项目成果

Kamiya A.: "Change of superoxide anion production of PMN in patients who underwent surgery for carcinoma of the esophagus." Akita J Med 17.

Kamiya A.：“接受食管癌手术的患者中 PMN 超氧阴离子产生的变化。”

Yokota K. et al: "The postoperative change of the PMN's superoxide anion production in esophageal cancer" Tumor & Infection 2:19-23, 1989.

Yokota K.等：“食管癌中中性粒细胞超氧阴离子产生的术后变化”肿瘤

横田憲一他: "食道癌術後の多核白血球Superoxide amion 産生能の変動-術後の低酸素、血症発現との関連において-" 腫瘍と感染. 2. 19-23 (1989)

Kenichi Yokota 等人：“食道癌手术后多核白细胞超氧化物胺离子产生能力的变化 - 与术后缺氧和血血症的关系”《肿瘤与感染》2. 19-23 (1989)。