Clinical Features and Thyroid Histology of T3-Predominant Graves' Disease.

T3为主型格雷夫斯病的临床特征和甲状腺组织学。

基本信息

批准号：
63570553
负责人：
TAKAMATSU Junta
金额：
$ 1.22万
依托单位：
Osaka Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

When patients with T_3 -predominant Graves' disease were compared with usual Graves' disease patients,1. Serum autoantibodies to thyroid peroxidase and TSH receptor were higher, while autoantibodies to thyroglobulin were not different. Thyroid-stimulating antibodies determined by cultured porcine thyroid cells were greater.2. The goiter size was greater with more hyperplastic epithelium and more intracolloidal vacuoles.3. Thyroid ^<123>I uptake was higher at 3h than 24h, suggesting enhanced thyroidal iodine turnover.4. The degree of exophthalmos of Graves' disease was not different.5. The activity of thyroid peroxidase was greater, while thyroglobulin content in the thyroid was smaller. Iodine content in thyroglobulin was also smaller. Thyroid 5' -deiodinase was greater, which may be one of the causes of increased serum T_3 relative to T_4.6. An experiment of coupling reaction using individual microsomal fractions and pooled thyroglobulin showed relatively increased T_3 production than T_4, suggesting a unique characteristic of thyroid peroxidase in this disorder.7. Clinical follow-up study showed that remission of hyperthyroidism was hardly obtained by antithyroid drug therapy. After subtotal thyroidectomy, the frequency of relapse was greater. While, after radioiodine therapy, the frequency of late-onset hypothyroidism was lower, indicating that radioiodine therapy is beneficial in this type of Graves' disease.

当将T_3-预先坟墓疾病的患者与常见的坟墓疾病患者进行比较时，1。甲状腺过氧化物酶和TSH受体的血清自身抗体更高，而对甲状腺球蛋白的自身抗体则没有差异。由培养的猪甲状腺细胞确定的甲状腺刺激抗体更大。2。甲状腺肿大小更大，具有更大的增生性上皮和更大的胶体内液泡3。甲状腺 ^<123> i的摄取率为3小时，高于24h，这表明甲状腺碘的周转率增强。4。坟墓疾病的外科观念程度没有差异。5。甲状腺过氧化物酶的活性更大，而甲状腺球蛋白含量较小。甲状腺球蛋白中的碘含量也小。甲状腺5' - 二碘酶更大，这可能是相对于T_4.6的血清T_3增加的原因之一。使用单个微粒体级分和合并的甲状腺球蛋白的偶联反应实验表现出比T_4相对增加的T_3产生，这表明该疾病中甲状腺过氧化物酶的独特特征。7。临床随访研究表明，甲状腺功能亢进症的缓解几乎是通过抗肌瘤药物治疗获得的。甲状腺次序切除术后，复发的频率更大。而放射碘治疗后，晚期甲状腺功能减退症的频率较低，这表明放射性碘治疗对这种Graves疾病是有益的。