Japan-Sino Cooperative Study on Risk Factor Analysis of Cardiovascular Diseases

日中心血管疾病危险因素分析合作研究

基本信息

批准号：
63045021
负责人：
YAMORI Yukio
金额：
$ 4.74万
依托单位：
Shimane Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63045021/
关键词：
Blood pressure Salt Body mass index Taurine 3 Methylhistidine Chinese Brazilian 栄養

项目摘要

Many epidemiological findings and experimental data have indicated that cardiovascular diseases are potentially preventable by dietary modifications. To investigate the relationships of dietary factors to blood pressure (BP) among Chinese and Brazilian populations, we carried out survey on 5 populations in China (1988-1989) and 2 populations, Japanese (JB) and Brazilian (BB), in Brazil (1990) according to international cooperative Cardiovascular Diseases and Alimentary Comparison Study protocol. From each population, 100 men and 100 women (50-54 y. o.) were recruited for BP measurement, 24-hrurine collection and blood test.Among 11 populations including 5 populations (Urumqi, Altai, Tulufan, Hetian, and Guangzhou) in this study and 6 populations (Beijing, Shanghai, Shijiazhuang, Guiyang, Guangzhou, and Lhasa) in former study (1985 and 1986), we assessed relationships of urinary electrolytes and amino acids to BP. Besides Body Mass Index (BMI), urinary salt excretion showed significant positive correlations with SBP and DBP (p<0.01, respectively). Taurine, rich in sea foods, divided by urea nitrogen and 3-methylhistidine, special component in muscles, divided by creatinine had significant inverse relationships to SBP and DBP (p<0.05, respectively).To assess differences between Japanese in Brazil (JB) and in Japan (JJ), we also carried out optional study in 3 areas (town, mountain village and fishing village) in Shimane prefecture in Japan. BMI in JB and BB were significantly higher than J (p<0.05). Hypertensive prevalence also higher in JB (41.2%) and BB (45.8%) than J (25-33%). The highest urinary salt excretion was observed in JB (14.0g) more than BB (12.7g) and mountain village (11.8g). Urinary taurine excretion in JB was 1.5 times higher than BB, but half less than JJ.In conclusion, sodium and obesity adversely affect BP, whereas animal protein may have beneficial influence on BP.

许多流行病学发现和实验数据表明，心血管疾病可能通过饮食改造可以预防。为了研究中国和巴西人口中饮食因素与血压（BP）的关系，我们根据国际心脏血管疾病和杀伤性比较研究协议对中国和巴西的5名人群（1988-1989）和2个人口进行了调查。在每个人群中，招募了100名男性和100名女性（50-54Y。O。）进行BP测量，24-挽回收集和血液测试。研究（1985年和1986年），我们评估了尿电解质和氨基酸与BP的关系。除了体重指数（BMI）外，尿盐排泄与SBP和DBP显示出显着的正相关（分别为P <0.01）。 Taurine, rich in sea foods, divided by urea nitrogen and 3-methylhistidine, special component in muscles, divided by creatinine had significant inverse relationships to SBP and DBP (p<0.05, respectively).To assess differences between Japanese in Brazil (JB) and in Japan (JJ), we also carried out optional study in 3 areas (town, mountain village and fishing village) in Shimane prefecture in Japan. JB和BB中的BMI显着高于J（P <0.05）。 JB（41.2％）和BB（45.8％）的高血压患病率也高于J（25-33％）。在JB（14.0G）中观察到的尿液排泄最高（12.7g）和山村（11.8G）。 JB中的尿转氨酸排泄物比BB高1.5倍，但结论是JJ.的一半，钠和肥胖对BP产生了不利影响，而动物蛋白可能对BP具有有益的影响。