Japan-Sino Cooperative Study on Risk Factor Analysis of Cardiovascular Diseases

日中心血管疾病危险因素分析合作研究

基本信息

批准号：
63045021
负责人：
YAMORI Yukio
金额：
$ 4.74万
依托单位：
Shimane Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63045021/
关键词：
Blood pressure Salt Body mass index Taurine 3 Methylhistidine Chinese Brazilian 栄養

项目摘要

Many epidemiological findings and experimental data have indicated that cardiovascular diseases are potentially preventable by dietary modifications. To investigate the relationships of dietary factors to blood pressure (BP) among Chinese and Brazilian populations, we carried out survey on 5 populations in China (1988-1989) and 2 populations, Japanese (JB) and Brazilian (BB), in Brazil (1990) according to international cooperative Cardiovascular Diseases and Alimentary Comparison Study protocol. From each population, 100 men and 100 women (50-54 y. o.) were recruited for BP measurement, 24-hrurine collection and blood test.Among 11 populations including 5 populations (Urumqi, Altai, Tulufan, Hetian, and Guangzhou) in this study and 6 populations (Beijing, Shanghai, Shijiazhuang, Guiyang, Guangzhou, and Lhasa) in former study (1985 and 1986), we assessed relationships of urinary electrolytes and amino acids to BP. Besides Body Mass Index (BMI), urinary salt excretion showed significant positive correlations with SBP and DBP (p<0.01, respectively). Taurine, rich in sea foods, divided by urea nitrogen and 3-methylhistidine, special component in muscles, divided by creatinine had significant inverse relationships to SBP and DBP (p<0.05, respectively).To assess differences between Japanese in Brazil (JB) and in Japan (JJ), we also carried out optional study in 3 areas (town, mountain village and fishing village) in Shimane prefecture in Japan. BMI in JB and BB were significantly higher than J (p<0.05). Hypertensive prevalence also higher in JB (41.2%) and BB (45.8%) than J (25-33%). The highest urinary salt excretion was observed in JB (14.0g) more than BB (12.7g) and mountain village (11.8g). Urinary taurine excretion in JB was 1.5 times higher than BB, but half less than JJ.In conclusion, sodium and obesity adversely affect BP, whereas animal protein may have beneficial influence on BP.

许多流行病学发现和实验数据表明，心血管疾病可以通过饮食改变来预防。为了探讨中国和巴西人群饮食因素与血压（BP）的关系，我们对中国的5个人群（1988-1989年）和巴西的日本人（JB）和巴西人（BB）2个人群进行了调查。 1990）根据国际合作心血管疾病和食物比较研究协议。每个人群中招募100名男性和100名女性（50-54岁）进行血压测量、24小时尿液采集和血液检测。本研究的11个人群包括5个人群（乌鲁木齐、阿尔泰、吐鲁番、和田和广州）以及以前研究（1985年和1986），我们评估了尿电解质和氨基酸与血压的关系。除体重指数（BMI）外，尿盐排泄量与收缩压和舒张压呈显着正相关（分别p<0.01）。海鲜中丰富的牛磺酸除以尿素氮和肌肉中的特殊成分3-甲基组氨酸除以肌酐与SBP和DBP呈显着负相关（分别p<0.05）。评估巴西日本人之间的差异（JB）在日本（JJ），我们还在日本岛根县的3个地区（城镇、山村、渔村）进行了选修学习。 JB 和 BB 的 BMI 显着高于 J (p<0.05)。 JB (41.2%) 和 BB (45.8%) 的高血压患病率也高于 J (25-33%)。尿盐排泄量最高的是JB（14.0g），高于BB（12.7g）和山村（11.8g）。 JB的尿牛磺酸排泄量比BB高1.5倍，但比JJ少一半。总之，钠和肥胖对血压有不利影响，而动物蛋白可能对血压有有利影响。