Identifying functional gene variants and non-additive effects to enhance the power of genomic selection of purebred pigs for crossbred performance

识别功能基因变异和非加性效应，以增强纯种猪杂交性能的基因组选择能力

• 批准号: 485526-2015
• 负责人: Plastow, Graham
• 金额: $ 6.34万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=692348
• 关键词: Identifying; functional; gene; variants; non

Genetically improving lean meat yield and pork quality is a key approach for the Canadian swine industry to enhance global competitiveness and overall profitability. Genomically enhanced estimated breeding values (GEBVs) are based on DNA marker genotypes and effects. GEBVs are used to increase the rate of genetic improvement for production traits, particularly for those that are difficult and/or expensive to measure, such as carcass yield and pork quality. The overall goal of this project is to improve the GEBVs for these traits through the integration of functional gene variants and better estimates of the overall genetic effect (additive and non-additive elements) by generating and using whole genomic sequence information and low density SNP panels. This work, a collaboration with a major Canadian and international pig breeding company will develop advanced knowledge and technology, which will benefit both the academic and industry partners. With this project, reduced genotyping cost (due to imputation) and enhanced power of genome prediction will significantly increase the adoption of genomic technologies in the Canadian swine industry. The delivery of novel genomic tools and techniques (e.g. sequence imputation, mating allocation), and experienced geneticists will improve Canadian pig breeding and selection programs . In addition, a large set of genomic data resources will be generated and shared, which represent valuable information for future genomic research in pigs. Knowledge of functional gene variants will also lead to new insights for the genomic architecture and underlying biology impacting pork yield and quality, and ultimately result in increased returns to the economic benefit of the swine industry.

基因改良瘦肉产量和猪肉品质是加拿大养猪业增强全球竞争力和整体盈利能力的关键途径。基因组增强估计育种值 (GEBV) 基于 DNA 标记基因型和效应。 GEBV 用于提高生产性状的遗传改良率，特别是那些难以测量和/或测量昂贵的性状，例如胴体产量和猪肉品质。该项目的总体目标是通过整合功能基因变异来改善这些性状的 GEBV，并通过生成和使用全基因组序列信息和低密度 SNP 组合来更好地估计总体遗传效应（加性和非加性元素） 。这项与加拿大和国际大型养猪公司合作的工作将开发先进的知识和技术，这将使学术和行业合作伙伴受益。通过该项目，基因分型成本的降低（由于插补）和基因组预测能力的增强将显着增加基因组技术在加拿大养猪业的采用。新型基因组工具和技术（例如序列插补、交配分配）以及经验丰富的遗传学家的提供将改善加拿大猪的育种和选择计划。此外，还将生成和共享大量基因组数据资源，为未来猪的基因组研究提供有价值的信息。对功能基因变异的了解还将带来对影响猪肉产量和质量的基因组结构和基础生物学的新见解，并最终提高养猪业的经济效益。