Seroepidemiological study on Ascaris suum infection in humans, an emerging zoonosis causing visceral larva migrans

人类猪蛔虫感染的血清流行病学研究，一种引起内脏幼虫移行症的新出现的人畜共患病

• 批准号: 09470070
• 负责人: NAWA Yukifumi
• 金额: $ 7.49万
• 依托单位: Miyazaki Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470070/
• 关键词: Ascaris suum; visceral larva migrans; zoonosis; pigs; epidemiology; immunodiagnosis; allergy; pollinosis; 幼虫移行症; 新興感染症; 好酸球; 疫学調査; 免疫血清診断; 人獣共通寄生虫症; 土壌媒介寄生虫症; 食品媒介寄生虫症; 新興・再興感染症; IgE; Ascaris suum; visceral larva migrans; zoonosis; pigs; epidemiology; immunodiagnosis; allergy; pollinosis; 幼虫移行症; 新興感染症; 好酸球; 疫学調査; 免疫血清診断; 人獣共通寄生虫症; 土壌媒介寄生虫症; 食品媒介寄生虫症; 新興・再興感染症; IgE

Ascaris suum is naturally an intestinal parasite of pigs. Viscerallarva migrans (VLM) characterized as pneumonitis and/or liver dysfunction with marked eosinophilia has been known to occur after experimental or accidental ingestion of A. suum embryonated eggs. However, natural occurrence of VLM due to A. suum has never been reported until our recent discovery of the presence of this disease in the pig-farming area in Kyushu. By the end of 1999, we have found 128 cases of immunoserologically diagnosed VLM probably caused by infection with A. suum. These cases included 2 ocular and 5 CNS involvement. After the informed concent has obtained, seroepidemiological survey was conducted in the pig-farming area in Kyushu; 6 towns in Miyazaki Prefecture and 2 towns in Kagoshima prefecture. The results show that 20-30% of the residents living in pig-farming area were seropositive against A. suum antigen by IgG-ELISA, while those living in non-pig-farming area showed less than 10% seropositivity against A. suum. Because parasitic infection has been supposed to affect and modulate allergic status, we examined the relationship between A. suum infection and allergy in the pig-farming area in Kyushu. For this purpose, specific IgE antibody against cedar pollen and/or mite allergen was measured as well as specific IgG/IgE antibodies against A. suum. The results show that the prevalence of allergic individuals having anti-cedar pollen and/or anti-mite IgE antibody was far greater in A. suum-infected group compared to that in parasite-free group. These results suggest that parasite infection is one of the important risk factor for allergic disease.

阿斯卡里斯·苏姆（Ascaris Suum）自然是猪的肠道寄生虫。众所周知，在实验或意外摄入苏脂曲霉的胚胎胚胎卵子后，已知发生的肺炎和/或肝功能障碍的特征是肺炎和/或肝功能障碍。然而，直到我们最近在九州的养猪场中发现这种疾病的存在，因此从未报道过由于A. suum引起的VLM的自然发生。到1999年底，我们发现了128例免疫学诊断的VLM病例可能是由A. suum感染引起的。这些病例包括2个眼和5个CNS参与。知情浓度获得后，在京都的养猪场进行了血清ePIDEMIOLOGOLOGY。宫崎骏县的6个城镇和Kagoshima县的2个城镇。结果表明，居住在猪养猪场的居民中有20-30％的居民对Suum抗原的血清阳性是IgG-Elisa，而居住在非幼犬区域的人则表现出针对A. suum的血清抗原。由于寄生虫感染被认为会影响和调节过敏状态，因此我们检查了九州猪养殖区域的曲霉感染与过敏之间的关系。为此，测量了针对雪松花粉和/或螨过敏原的特异性IgE抗体，以及针对A. suum的特定IgG/IgE抗体。结果表明，与无寄生虫组相比，在曲霉感染的组中，具有抗纤维花粉和/或抗分泌IgE抗体的过敏个体的患病率要大得多。这些结果表明，寄生虫感染是过敏性疾病的重要危险因素之一。