Research hot cell with active air compression and cool down system

研究具有主动空气压缩和冷却系统的热室

• 批准号: 518282844
• 金额: --
• 依托单位: Johannes Gutenberg-Universität Mainz
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/518282844?language=en
• 关键词: Research; hot; cell; active; air; Research; hot; cell; active; air

Subject of the application a lead-shielded, gas-tight research hot cell with accessories for handling short-lived, radioactive cyclotron products. The research hot cell serves to develop the full capacity of the GE PETtrace 700S cyclotron at Johannes Gutenberg University (JGU), which is designed for the production of radioactive carbon-11 (11C) and fluorine-18 (18F) but cannot be used in research due to a lack of infrastructure. As part of the appointment of a new W3 professor for radiopharmaceutical chemistry at JGU, the nuclides 11C and 18F became the focus of a cyclotron-based research profile, from basic research to clinical studies. Currently, this goal is hardly achievable, since working with gaseous 11C is associated with a high risk of unintentional activity release, while radiosynthesis has to be carried out manually, i.e. with low starting activities. As per the operating permit, 11C and 18F must be delivered into a hot cell in room 01-462 (building 1264). This is a clean room area designed for the production of radiopharmaceuticals for human applications. Use for pharmaceutical purposes and basic chemical research are incompatible. The room is practically inaccessible to academic staff. Radionuclides are brought into the research laboratories by hand and manipulated manually in shielded fume hoods, which is not a timely standard. No hot cells are available for research. For 11C research, manual handling is problematic as it is associated with a high risk of release. The building has an air filter system, which prevents the release of activity into the environment. However, this filter system is unsuitable for low-molecular weight gases, i.e. [11C]carbon dioxide, the primary product of 11C production, is not retained. The installation of a research hot cell equipped with an active air containment system to prevent the release of contaminated exhaust air in a lab next to the clean room will remedy the situation. The new cell is connected to the cyclotron via a target switch. A new client station allows for remote control of the cyclotron directly from the laboratory. The new cell solves the above problems and thus improves the effective cross section of the large DFG-funded devices at JGU (cyclotron, PET and PET/MR scanner). In the future, fully automated radiosynthesis in the cell will allow the use of high 11C and 18F activities, so that high molar activities can be achieved in order to carry out PET studies under ideal conditions. The hot cell allows a significant increase in the capacity of the cyclotron in research and opens up a wide range of opportunities for close cooperation between the working groups for nuclear chemistry, organic chemistry, pharmacy, neuroscience and nuclear medicine on issues of radiopharmaceutical sciences/imaging. By bundling such research competence, new impulses can be implemented in everything from basic research to translational research.

应用程序的主题是铅屏蔽的气密研究热单元，配有用于处理短寿命的放射性回旋产物的配件。该研究热细胞可在约翰内斯·古腾堡大学（JGU）开发GE Pettrace 700s Cyclotron的全部容量，该能力用于生产放射性碳-11（11C）和氟-18（18F），但由于缺乏基础设施而无法用于研究。作为JGU的新W3放射性药物化学教授任命的一部分，核素11C和18F成为了基于基础研究到临床研究的基于转基因研究概况的重点。目前，这一目标几乎是无法实现的，因为使用气态11C与无意间活动的高风险相关，而放射合成的风险必须手动进行，即起始活动较低。根据操作许可证，必须将11C和18F运送到01-462室（1264号建筑物）的热单元中。这是一个干净的房间区域，旨在生产用于人类应用的放射性药物。用于药物目的和基本化学研究是不兼容的。这个房间实际上是学术人员无法访问的。放射性核素被手工带入研究实验室，并用屏蔽的烟雾罩手动操纵，这不是及时的标准。没有热细胞可进行研究。对于11C研究，手动处理是有问题的，因为它与释放的高风险有关。该建筑物具有空气滤清器系统，可防止活动释放到环境中。但是，这种过滤系统不适合低分子量的气体，即[11C]二氧化碳是11C产生的主要产物，因此不保留。安装了配备有效空气封闭系统的研究热单元，以防止在清洁室旁边的实验室释放受污染的排气空气，这将弥补这种情况。新单元通过目标开关连接到回旋子。一个新的客户端站允许直接从实验室远程控制回旋器。新细胞解决了上述问题，从而改善了JGU（Cyclotron，PET和PET和MR Scanner）的大型DFG资助设备的有效横截面。将来，细胞中的全自动放射合成将允许使用高11C和18F活动，因此可以在理想条件下进行宠物研究来实现高摩尔活性。热细胞可以在研究中大幅提高回旋子的能力，并为放射性药物科学/成像问题开辟了核化学，有机化学，药学，神经科学和核医学之间密切合​​作的广泛机会。通过捆绑此类研究能力，可以在从基础研究到翻译研究的所有方面实施新的冲动。