Research hot cell with active air compression and cool down system

研究具有主动空气压缩和冷却系统的热室

• 批准号: 518282844
• 金额: --
• 依托单位: Johannes Gutenberg-Universität Mainz
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/518282844?language=en
• 关键词: Research; hot; cell; active; air

Subject of the application a lead-shielded, gas-tight research hot cell with accessories for handling short-lived, radioactive cyclotron products. The research hot cell serves to develop the full capacity of the GE PETtrace 700S cyclotron at Johannes Gutenberg University (JGU), which is designed for the production of radioactive carbon-11 (11C) and fluorine-18 (18F) but cannot be used in research due to a lack of infrastructure. As part of the appointment of a new W3 professor for radiopharmaceutical chemistry at JGU, the nuclides 11C and 18F became the focus of a cyclotron-based research profile, from basic research to clinical studies. Currently, this goal is hardly achievable, since working with gaseous 11C is associated with a high risk of unintentional activity release, while radiosynthesis has to be carried out manually, i.e. with low starting activities. As per the operating permit, 11C and 18F must be delivered into a hot cell in room 01-462 (building 1264). This is a clean room area designed for the production of radiopharmaceuticals for human applications. Use for pharmaceutical purposes and basic chemical research are incompatible. The room is practically inaccessible to academic staff. Radionuclides are brought into the research laboratories by hand and manipulated manually in shielded fume hoods, which is not a timely standard. No hot cells are available for research. For 11C research, manual handling is problematic as it is associated with a high risk of release. The building has an air filter system, which prevents the release of activity into the environment. However, this filter system is unsuitable for low-molecular weight gases, i.e. [11C]carbon dioxide, the primary product of 11C production, is not retained. The installation of a research hot cell equipped with an active air containment system to prevent the release of contaminated exhaust air in a lab next to the clean room will remedy the situation. The new cell is connected to the cyclotron via a target switch. A new client station allows for remote control of the cyclotron directly from the laboratory. The new cell solves the above problems and thus improves the effective cross section of the large DFG-funded devices at JGU (cyclotron, PET and PET/MR scanner). In the future, fully automated radiosynthesis in the cell will allow the use of high 11C and 18F activities, so that high molar activities can be achieved in order to carry out PET studies under ideal conditions. The hot cell allows a significant increase in the capacity of the cyclotron in research and opens up a wide range of opportunities for close cooperation between the working groups for nuclear chemistry, organic chemistry, pharmacy, neuroscience and nuclear medicine on issues of radiopharmaceutical sciences/imaging. By bundling such research competence, new impulses can be implemented in everything from basic research to translational research.

该应用的主题是铅屏蔽气密研究热室，配有用于处理短寿命放射性回旋加速器产品的附件。研究热室用于开发约翰内斯古腾堡大学 (JGU) 的 GE PETtrace 700S 回旋加速器的全部能力，该回旋加速器设计用于生产放射性碳 11 (11C) 和氟 18 (18F)，但不能用于由于缺乏基础设施而进行的研究。作为 JGU 任命新的 W3 放射性药物化学教授的一部分，核素 11C 和 18F 成为基于回旋加速器的研究重点，从基础研究到临床研究。目前，这一目标很难实现，因为使用气态 11C 与无意活性释放的高风险相关，而放射合成必须手动进行，即起始活性较低。根据运营许可证，11C 和 18F 必须交付到 01-462 室（1264 号楼）的热室中。这是一个洁净室区域，专为生产人类应用的放射性药物而设计。用于制药目的和基础化学研究是不相容的。学术人员实际上无法进入该房间。放射性核素是手工带入研究实验室并在屏蔽通风柜中手动操作的，这不是一个及时的标准。没有可用于研究的热室。对于 11C 研究，手动处理是有问题的，因为它与释放的高风险相关。该建筑设有空气过滤系统，可防止活性物质释放到环境中。然而，该过滤系统不适合低分子量气体，即11C生产的主要产物[11C]二氧化碳不会被保留。在洁净室旁边的实验室中安装配备主动空气遏制系统的研究热室，以防止受污染的废气释放，将弥补这种情况。新单元通过目标开关连接到回旋加速器。新的客户端站允许直接从实验室远程控制回旋加速器。新单元解决了上述问题，从而提高了 JGU DFG 资助的大型设备（回旋加速器、PET 和 PET/MR 扫描仪）的有效横截面。未来，细胞内的全自动放射合成将允许使用高11C和18F活性，从而可以实现高摩尔活性，以便在理想条件下进行PET研究。热室可以显着提高回旋加速器的研究能力，并为核化学、有机化学、药学、神经科学和核医学工作组在放射性药物科学/成像问题上的密切合作开辟了广泛的机会。通过整合这些研究能力，可以在从基础研究到转化研究的各个领域实施新的推动力。