Neuromuscular mechanisms governing knee joint biomechanics during normal gait

正常步态下控制膝关节生物力学的神经肌肉机制

基本信息

批准号：
418025-2013
负责人：
Hunt, Michael
金额：
$ 2.11万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2018
资助国家：
加拿大
起止时间：
2018-01-01 至 2019-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=654106
关键词：
Neuromuscular mechanisms governing knee joint

项目摘要

During ambulation, the joints of the lower limb - the knee in particular - must withstand large forces exerted onto them to permit the smooth and efficient continuation of forward progression. While structures such as bones and ligaments can assist in the distribution of these forces, our muscles are believed to be primarily responsible for absorption of these forces and to protect the joints over time. Previous researchers have attempted to model the distribution of forces throughout the knee joint during walking, though these models are limited in their accuracy due to a lack of information regarding the anatomy of the lower limb during weight-bearing activities and the difficulty in isolating the effects of muscle activation on movement parameters. The proposed mechanistic research program will provide new information about not only the relationships between aspects of muscle function and loading at the knee joint during walking, but the neuromuscular control of normal human movement. ****We will investigate the relationships between measures of knee joint loading and neuromuscular outcomes such as output from the brain, muscle power, and the relative timing of different lower limb muscles. We will also combine images of knee joint structure during weight-bearing to produce a more accurate model of the complex relationship between muscle and joints during movement. This proposed research will provide an integrated analysis of neuromuscular function from the brain, through the nerves, and out to the muscles which will act as a new model for neuromuscular assessment of physical function. It will provide evidence on the effects of diminished muscle function which will not only serve as a basis for future applied research, but will help to refine current models of normal movement. Finally, this basic research on normal function may be used by future researchers to develop optimal treatment strategies for people with diminished muscle and joint function.**

在行走过程中，下肢的关节（尤其是膝盖）必须承受施加在其上的巨大力，以允许平稳有效地继续向前前进。虽然骨骼和韧带等结构可以帮助分布这些力，但我们的肌肉被认为主要负责吸收这些力并随着时间的推移保护关节。先前的研究人员曾尝试对步行过程中整个膝关节的力分布进行建模，但由于缺乏有关负重活动期间下肢解剖结构的信息以及难以隔离影响，这些模型的准确性受到限制肌肉激活对运动参数的影响。拟议的机械研究计划不仅将提供有关行走过程中肌肉功能和膝关节负荷之间关系的新信息，而且还将提供有关正常人体运动的神经肌肉控制的新信息。 ****我们将研究膝关节负荷测量值与神经肌肉结果（例如大脑输出、肌肉力量以及不同下肢肌肉的相对时间）之间的关系。我们还将结合负重过程中膝关节结构的图像，以生成运动过程中肌肉和关节之间复杂关系的更准确模型。这项拟议的研究将对从大脑、神经到肌肉的神经肌肉功能进行综合分析，这将作为身体功能神经肌肉评估的新模型。它将提供有关肌肉功能减弱的影响的证据，这不仅可以作为未来应用研究的基础，而且有助于完善当前的正常运动模型。最后，未来的研究人员可以利用这项关于正常功能的基础研究来为肌肉和关节功能减弱的人制定最佳治疗策略。 **