Developing technology for imaging cancer tumors and sentinel lymph nodes utilizing sonic wave emission by magnetically stimulated particles

开发利用磁刺激粒子的声波发射对癌症肿瘤和前哨淋巴结进行成像的技术

• 批准号: 21240054
• 负责人: MATSUSHITA Nobuhiro
• 金额: $ 29.87万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21240054/
• 关键词: 励磁音響効果; 画像装置; がん診断; フェライトナノ粒子; 磁性ビーズ; センチネルリンパ節診断; 標的化; 磁気ハイパーサーミア; 音源位置; 画像化; 速度ポテンシャル; インパルス応答; フォトフォニック; センチネルリンパ節; フェライトビーズ; 超音波画像; 腫瘍マーカー; 低侵襲性医療; 断層画像撮影

In order to apply to sentinel lymph node mapping by emission of acoustic waves by magnetically-stimulated particles, we developed new devices which will enable 3D magnetic particle imaging by using only one microphone. They are(1) Bunny ear Reflector Microphone(BERM) in which a microphone is mounted on a asymmetric position of a reflector and the impulse response of burst acoustic waves propagated directly and reflected by the reflector is analyzed. And(2)"Random Path Holophonic Sensor" in which the impulse response of burst ultrasonic waves propagated through the small apertures distributed randomly(after maximal-length sequences) on a microphone head is analyzed. Simulation experiments confirmed the operation principle of our new devices. We also developed "two-step ligand exchange reaction", by which we successfully synthesized ferrite beads with narrow size distribution ; when their average size was 20 nm they showed strong magneto-acoustic effect and they were accumulated at the first lymph nodes(pseudo sentinel lymph nodes) of a mouse at a high efficiency.

为了通过磁刺激粒子发射声波应用于前哨淋巴结测绘，我们开发了新设备，只需使用一个麦克风即可实现 3D 磁粒子成像。它们是：(1)兔耳反射式麦克风(BERM)，其中麦克风安装在反射器的不对称位置上，并分析直接传播并经反射器反射的突发声波的脉冲响应。 (2)“随机路径全息传感器”，分析了通过麦克风头上随机分布的小孔(在最大长度序列之后)传播的突发超声波的脉冲响应。模拟实验证实了我们新装置的工作原理。我们还开发了“两步配体交换反应”，成功合成了窄粒径分布的铁氧体磁珠；当它们的平均尺寸为20 nm时，它们表现出强烈的磁声效应，并且它们在小鼠的第一淋巴结（伪前哨淋巴结）处高效积累。

项目成果

Anticancer sentinel-lymph-node mapping by sonic waves generated by magnetic beads under ac magnetic field

交流磁场下磁珠产生的声波进行抗癌前哨淋巴结定位

• 发表时间: 2009
• 作者: Abe M.;Kakegawa K.;Ueda T.;NakagawaT.;Handa H.
• 通讯作者: Handa H.

Aqueous Solution Synthesis of Size-Controlled Magnetite Nanoparticles for Bio Magnetic Beads

用于生物磁珠的尺寸控制的磁铁矿纳米粒子的水溶液合成

• 发表时间: 2009
• 作者: FUSE K.;Taniguchi T.;Okada K.;andMatsushita N.
• 通讯作者: andMatsushita N.

Hydrothermal Growth of Fatty Acid Stabilized Iron Oxide Nanocrystals

• DOI: 10.1021/jp8062433
• 发表时间: 2009-01
• 期刊: Journal of Physical Chemistry C
• 影响因子: 3.7
• 作者: T. Taniguchi;Kazunori Nakagawa;Tomoaki Watanabe;N. Matsushita;M. Yoshimura

Rational Hydrothermal Route to Functional Metal Oxide Nanoparticles

功能性金属氧化物纳米颗粒的合理水热路线

• 发表时间: 2009
• 作者: Taniguchi T.;Watanabe T.;YoshimuraM.;and Matsushita N.
• 通讯作者: and Matsushita N.

スピンスプレー法による結晶化α-Fe_2O_3薄膜の作製

旋喷法制备α-Fe_2O_3晶化薄膜

• 发表时间: 2011
• 作者: 武田理恵;洪正洙;勝又健一;岡田清;松下伸広
• 通讯作者: 松下伸広