Elucidation of the aging process of human heat adaptability and strategies for delaying it

阐明人体热适应性衰老过程及延缓衰老的策略

• 批准号: 20247035
• 负责人: INOUE Yoshimitsu
• 金额: $ 29.54万
• 依托单位: Osaka International University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20247035/
• 关键词: 環境適応能; 全身的協関; 高齢者; 体温調節; 発汗; 循環調節; 汗腺機能; 皮膚温冷覚閾値; 季節差; 最大酸素摂取量; 脱酸素化量; 皮膚血管収縮機能; 起立耐性; 筋酸素利用能; 時間分解・近赤外分光装置; 血栓形成; イオントフォレーシス法; アセチルコリン; 直接刺激性発汗; 軸索反射性発汗; 運動鍛錬者; 運動非鍛錬者; 性差; 運動トレーニング

This research project addressed the ways in which human heat adaptability changes with aging from the viewpoint of whole body coordination. Our findings suggest that in men and women, age-related decrement in thermoregulatory function may involve the input system, effector system, output system, and central system in that order, and the decrement in sweat gland function in the lower limbs may proceed from the lower legs to thigh and from posterior to anterior areas. Our results suggest that non-thermal heat loss response to combined input and sex differences in heat loss responses in young adults tended to decrease with aging. They also suggest that the enhancement of peripheral sweat function toward summer was delayed with aging, the contribution of the skin blood flow adjustment to orthostatic tolerance during the summer heat is smaller in older people, and older people are more prone to thrombogenesis in the summer. Although we failed to find a strategy to delay aging of input and output systems of the thermoregulatory function, the establishment of an exercise habit is effective for the effector system.

该研究项目从全身协调的角度探讨了人体热适应性随衰老的变化方式。我们的研究结果表明，在男性和女性中，年龄相关的体温调节功能下降可能依次涉及输入系统、效应系统、输出系统和中枢系统，而下肢汗腺功能的下降可能来自于小腿到大腿，从后部到前部。我们的结果表明，年轻人对组合输入的非热热损失反应和热损失反应的性别差异往往随着年龄的增长而减少。他们还认为，随着年龄的增长，末梢汗液功能向夏季的增强会延迟，老年人夏季炎热期间皮肤血流调节对直立耐受力的贡献较小，老年人在夏季更容易发生血栓。虽然我们未能找到延缓体温调节功能输入输出系统衰老的策略，但运动习惯的建立对于效应系统是有效的。

项目成果

Cutaneous vasodilation response to a linear increase in air temperature from 28℃ to 40℃ in prepubertal boys and young men.

青春期前男孩和年轻男性对气温从 28℃ 线性升高到 40℃ 的皮肤血管舒张反应。

• 发表时间: 2009
• 期刊: J Physiol Anthropol 28(in press)
• 作者: Inoue Y;Ichinose TK;Nakamura S;Ueda H;Kondo N;Araki T
• 通讯作者: Araki T

Comparison of invasive and non-invasive measures of arterial blood pressure in heat-stressed humans.

热应激人群有创和无创动脉血压测量的比较。

• 发表时间: 2009
• 作者: Shibasaki M;et al.
• 通讯作者: et al.

水中運動トレーニングが熱放散反応に及ぼす影響

水下运动训练对散热反应的影响

• 发表时间: 2010
• 作者: 一之瀬智子;柴田亜耶;中川梓;小倉幸雄;井上芳光
• 通讯作者: 井上芳光

Temperature regulation during exercise in humans(招待講演)

人体运动时的温度调节（特邀报告）

• 发表时间: 2009
• 作者: Matsumoto;D.;H. Yamane;and R. Tao;Kondo N
• 通讯作者: Kondo N

Reply to C. Schwiening's commentary.

回复 C. Schwiening 的评论。

• 发表时间: 2011
• 期刊: Exp Physiol 96
• 作者: CD Ichinose-Kuwahara T;Inoue Y
• 通讯作者: Inoue Y