DEVELOPMENT OF MICRO FRUID CONTROL SYSTEM BY USING MICROSTEREOLITHOGRAPHY

利用微立体光刻技术开发微流体控制系统

• 批准号: 13124205
• 负责人: IKUTA Koji
• 金额: $ 30.21万
• 依托单位: NAGOYA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13124205/
• 关键词: Biochemical IC; Micro Stereolithography; MEMS; Two-Photon Stereolithography; Tailor-made Medicine; Implantable Micro Device; Biodegradable Polymer; Optically Driven Micromachine; 2光子高速光造形法; 光硬化性樹脂; 生体適合性材料; テーラーメード製薬; 体内埋込型デバイス; マイクロポンプ; マイク

Biochemical IC chips for future micro/nano chemical device have been investigated. We took a systematic research approach for development compared with conventional research project.1) New fabrication process to create real three-dimensional micro/nano structures has been developed. The micro/nano stereo lithography process originally developed in lkuta's laboratory was further advanced for this project. Nano scale needle and tweezers were fabricated and driven by laser trapping. Smooth remote drive and ft Newton scale force sensing were demonstrated experimentally.2) New chip-sets of biochemical IC chips have been successfully developed and their functions were verified. Cell-free protein synthesis with advanced micro pump chips was succeeded. Several proteins have been synthesized from DNA without any living cell. This function is the key technology for not only post genome research but also order-made medicine based.3) Homogenizer chips to destroy cell and tissue in micro scale without damaging cell protein. Simple and effective coupling method between biochemical IC chips was developed. The silicon-rubber coupling can make a tight sealing. These results directly contribute to real total micro analysis process and devices.4) Artificial kidney device utilizing micro stereo lithography has been developed. Miniaturization and rat test were carried out successfully in Prof. Nagakura's lab.5) New technique for cell biology by using micro fluidics has been proposed and verified by Prof. Sokabe and Prof. Naruse. Since many new knowledge in life science were obtained through the new approach, it was made clear that micro chemical devices such as biochemical IC chips can contribute to basic life science as well as biomedical applications.

已经研究了用于未来微型/纳米化学装置的生化IC芯片。与常规研究项目相比，我们采用了一种系统的开发方法。1）开发了创建实际三维微型/纳米结构的新制造过程。该项目最初在Lkuta实验室开发的微/纳米立体声光刻过程。纳米秤针和镊子是由激光诱捕制造和驱动的。经过实验证明了光滑的远程驱动器和牛顿量表的力传感。2）生化IC芯片的新芯片已经成功地开发出来，并验证了其功能。无细胞的蛋白质与高级微泵芯片成功。几种蛋白质已从没有任何活细胞的DNA中合成。该功能不仅是基因组研究后，而且是基于订单医学的关键技术。3）均质芯片以微小破坏细胞和组织而不会损害细胞蛋白。开发了生化IC芯片之间的简单有效的耦合方法。硅橡胶耦合可以使密封紧密。这些结果直接有助于实际的总微分析过程和设备。4）已经开发了使用微观立体光刻的人工肾脏装置。在Nagakura教授的实验室成功进行了微型化和大鼠测试。5）通过使用微流体的新技术，已由Sokabe教授和Naruse教授提出并验证。由于通过新方法获得了许多生活科学方面的新知识，因此很明显，诸如生化IC芯片之类的微型化学设备可以为基本的生命科学以及生物医学应用做出贡献。

项目成果

Makoto Nokata, Koji Ikuta, Hideki Ishii: "Safety-Optimizing Method of Human-Care Robot Design and Control"Proc.of IEEE International Conference on Robotics and Automation (ICRA'02). 1991-1996 (2002)

Makoto Nokata、Koji Ikuta、Hideki Ishii：“人类护理机器人设计与控制的安全优化方法”Proc.of IEEE 国际机器人与自动化会议 (ICRA02)。

Shoji Maruo, Koji Ikuta, Hayato Korogi: "Force-Controllable, Optically Driven Micromachines Fabricated by Single-Step Two-Photon Microstereolithography"Journal of Microelectromechanical Systems. 12・5. 533-539 (2003)

Shoji Maruo、Koji Ikuta、Hayato Korogi：“通过单步双光子微立体光刻技术制造的力可控光学驱动微型机器”《微机电系统杂志》12・5（2003 年）。

T.Nagakura, S.Maruo, K.Ikuta: "The Study of Micro Blood Sugar Control Device Without Energy Supply for Diabetes Therapy"Digest of Technical Papers of the 12th International Conference on Solid State Sensors, Actuators and Microsystems. 2. 1209-1212 (2003)

T.Nagakura、S.Maruo、K.Ikuta：“糖尿病治疗中无能量供应的微血糖控制装置的研究”第十二届国际固态传感器、执行器和微系统会议技术论文摘要。

M.Nokata, K.Ikuta, H.Ishii: "Safety-Optimizing Method of Human-Care Robot Design and Control"Proc. of the 2002 IEEE Robotics and Automation Conference (ICRA'02). 1991-1996 (2002)

M.Nokata，K.Ikuta，H.Ishii：“人类护理机器人设计与控制的安全优化方法”Proc。

K.Ikuta, H.Ichikawa, K.Suzuki: "Safety-active Catheter with Multiple-segments Driven by Micro Hydraulic Actuators"Proc. of Medical Image Computing and Computer-Assisted Intervention (MICCAI'02). 182-191 (2002)

K.Ikuta、H.Ich​​ikawa、K.Suzuki：“微型液压执行器驱动的多段安全主动导管”Proc。