DEVELOPMENT OF MICRO FRUID CONTROL SYSTEM BY USING MICROSTEREOLITHOGRAPHY

利用微立体光刻技术开发微流体控制系统

• 批准号: 13124205
• 负责人: IKUTA Koji
• 金额: $ 30.21万
• 依托单位: NAGOYA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13124205/
• 关键词: Biochemical IC; Micro Stereolithography; MEMS; Two-Photon Stereolithography; Tailor-made Medicine; Implantable Micro Device; Biodegradable Polymer; Optically Driven Micromachine; 2光子高速光造形法; 光硬化性樹脂; 生体適合性材料; テーラーメード製薬; 体内埋込型デバイス; マイクロポンプ; マイク

Biochemical IC chips for future micro/nano chemical device have been investigated. We took a systematic research approach for development compared with conventional research project.1) New fabrication process to create real three-dimensional micro/nano structures has been developed. The micro/nano stereo lithography process originally developed in lkuta's laboratory was further advanced for this project. Nano scale needle and tweezers were fabricated and driven by laser trapping. Smooth remote drive and ft Newton scale force sensing were demonstrated experimentally.2) New chip-sets of biochemical IC chips have been successfully developed and their functions were verified. Cell-free protein synthesis with advanced micro pump chips was succeeded. Several proteins have been synthesized from DNA without any living cell. This function is the key technology for not only post genome research but also order-made medicine based.3) Homogenizer chips to destroy cell and tissue in micro scale without damaging cell protein. Simple and effective coupling method between biochemical IC chips was developed. The silicon-rubber coupling can make a tight sealing. These results directly contribute to real total micro analysis process and devices.4) Artificial kidney device utilizing micro stereo lithography has been developed. Miniaturization and rat test were carried out successfully in Prof. Nagakura's lab.5) New technique for cell biology by using micro fluidics has been proposed and verified by Prof. Sokabe and Prof. Naruse. Since many new knowledge in life science were obtained through the new approach, it was made clear that micro chemical devices such as biochemical IC chips can contribute to basic life science as well as biomedical applications.

研究了未来微纳化学器件的生化IC芯片。与传统的研究项目相比，我们采取了系统的研究方法进行开发。1）开发了创建真实三维微/纳米结构的新制造工艺。最初在 lkuta 实验室开发的微/纳米立体光刻工艺在该项目中得到了进一步发展。纳米级针和镊子是通过激光捕获制造和驱动的。平滑远程驱动和ft牛顿尺度力传感进行了实验论证。2)新型生​​化IC芯片组研制成功并进行功能验证。利用先进的微泵芯片成功实现无细胞蛋白质合成。一些蛋白质已经在没有任何活细胞的情况下由 DNA 合成。该功能不仅是基因组后研究的关键技术，也是基于订单的医学的关键技术。3) 均质器芯片，可在微观尺度上破坏细胞和组织而不破坏细胞蛋白。开发了生化IC芯片之间简单有效的耦合方法。硅橡胶联轴器可实现紧密密封。这些结果直接有助于真正的整体微分析过程和装置。4)利用微立体光刻技术的人工肾装置已经开发出来。 Nagakura教授的实验室成功地进行了小型化和大鼠实验。5) Sokabe教授和Naruse教授提出并验证了利用微流控技术进行细胞生物学的新技术。由于通过新方法获得了生命科学领域的许多新知识，因此明确了生化IC芯片等微化学器件可以为基础生命科学以及生物医学应用做出贡献。

项目成果

K.Ikuta, S.Maruo, T.Hasegawa, T.Adachi: "Micro-stereolithography and its Application to Biochemcal IC Chip"Proc. of SPIE. 360-374 (2001)

K.Ikuta、S.Maruo、T.Hasekawa、T.Adachi：“微立体光刻及其在生化 IC 芯片中的应用”Proc。

K.Ikuta, Y.Sasaki, H.Maegawa, S.Maruo: "Biochemical IC chips for pretreatment in biochemical experiments"Proc. of the 15th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2003). 343-346 (2003)

K.Ikuta、Y.Sasaki、H.Maekawa、S.Maruo：“用于生化实验预处理的生化IC芯片”Proc。

K.Ikuta, M.Nokata, H.Ishii: "Safety Evaluation method of Human-Care Robot Control and Special Robot Simulator"Proc. of 7th International Conference on Rehabilitation Robotics (ICORR'01). 317-326 (2001)

K.Ikuta，M.Nokata，H.Ishii：“载人机器人控制和特种机器人模拟器的安全评估方法”Proc。

長倉俊明, 石原 謙 他: "糖尿病治療のための自立型微小インスリン注入システムの研究"中谷電子計測技術振興財団 年報. 15. 60-64 (2001)

Toshiaki Nagakura、Ken Ishihara 等：“用于糖尿病治疗的自支撑微胰岛素注射系统的研究”Nakatani 电子测量技术促进基金会年度报告 15. 60-64 (2001)。

K.Ikuta, K.Iritani, J.Fukuyama: "Mobile Virtual Endoscope System with Haptic and Visual Information for Non-invasive Inspection Training"Proc. of the 2001 IEEE Robotics and Automation Conference (ICRA'01). 2037-2044 (2001)

K.Ikuta、K.Iritani、J.Fukuyama：“具有触觉和视觉信息的移动虚拟内窥镜系统，用于非侵入性检查培训”Proc。