Development of titanium alloy for implant with high corrosion resistance and prompt bone connectivity

开发具有高耐腐蚀性和快速骨连接的植入物钛合金

基本信息

批准号：
16591956
负责人：
NAKAGAWA Masaharu
金额：
$ 2.3万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591956/
关键词：
Titanium Titanium Alloy Bioactivity Surface Modification Hydro-thermal Treatment Implant Bone Contact Ratio Bone Connective 細胞培養

项目摘要

Because titanium has an excellent corrosion resistance and a biocompatibility, it is used for an artificial hip joint and a dental implant, etc. as a metallic material for the living body. The compatibility of titanium with the bone is more excellent than that of other materials. However, there is a case removed after implantation by the micro movement etc. The aim of this research is a development of surface modification method for the titanium implant to give a strong and prompt bone.There is a method of calling the alkali treatment to make one of the expected surface modification method extract a bone-like apatite layer directly to the surface of titanium. The material is soaked in a simulated body fluid, and the bioactivity of titanium is appreciable according to whether apatite precipitate on it.In this study, in order to fix a small amount of Ca to the surface of titanium beforehand, a hydro-thermal treatment was given at 200C by using 10mmol/L CaCl_2 solution paying attention to the generation mechanism of apatite in vivo. Pure Ti and the Ti alloy with this treatment showed that an initial attachment and a proliferation speed of the osteoblast cell gathered from rat's bone marrow were higher than those with the alkali treatment.The titanium implant with this treatment was implanted in rat's tibia bone and interface of bone and implant was observed. After implantation for 1 week, the bone contact rate of the titanium with this treatment indicated the more than 55% while the titanium with non-treatment indicated 5.7%. And that value reached about 100% after implantation for 4 weeks.From the above-mentioned result, it was suggested that the hydro-thermal treatment that used the CaCl_2 solution was a surface modification method giving bioactivity for titanium.

由于钛具有优异的耐腐蚀性和生物相容性，因此作为生物体的金属材料用于人工髋关节和牙科植入物等。钛与骨骼的相容性比其他材料更加优异。然而，也存在植入后因微移动等原因而被移除的情况。本研究的目的是开发钛植入物的表面改性方法，以赋予钛植入物坚固且迅速的骨。有一种称为碱处理的方法，使钛植入物变得坚固且迅速。一种预期的表面改性方法将骨状磷灰石层直接提取到钛表面。将材料浸泡在模拟体液中，根据其上是否析出磷灰石来判断钛的生物活性。本研究通过水热处理，预先将少量的Ca固定在钛表面。在200℃下用10mmol/L CaCl_2溶液给予，关注体内磷灰石的生成机制。纯钛和经该处理的钛合金显示，从大鼠骨髓采集的成骨细胞的初始附着和增殖速度均高于碱处理的。经该处理的钛植入物植入大鼠胫骨和界面观察骨和植入物的情况。植入1周后，经过处理的钛材骨接触率超过55%，而未经处理的钛材骨接触率为5.7%。植入4周后该值达到约100%。从上述结果表明，使用CaCl_2溶液的水热处理是一种赋予钛生物活性的表面改性方法。