Development of treatment method for prevention of dental caries and dentin hypersensitivity with silica-fluoride compound

硅氟化合物预防龋齿和牙本质过敏的治疗方法的开发

• 批准号: 16591916
• 负责人: SUGE Toshiyuki
• 金额: $ 2.24万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591916/
• 关键词: ammonium hexafluorosilicate; diamine silver fluoride; fluoride; dentin hypersensitivity; dental caries; silica; calcium phosphate; dentin tubule; イヌ生活歯; 操作型電子顕微鏡; 人工唾液; 象牙質透過性; 象牙細管内液; フッ化カルシウム

Diamine silver fluoride (Saforide) is clinical use for prevent of progress of dental caries and desensitizing for hypersensitive tooth. Unfortunately, diamine silver fluoride stained tooth black due to silver precipitation. Therefore, diamine silver fluoride is mainly applied deciduous tooth. To overcome this drawback, ammonium hexafluorosilicate was prepared. The purpose of this study was to evaluate the occluding ability of dentin tubules and acid resistance of bovine tooth after ammonium hexafluorosilicate treatment. The surface of dentin disks was observed with scanning electron microscopy (SEM) at immediately after ammonium hexafluorosilicate treatment and 7 days after immersion in synthetic saliva. SEM observation showed that open dentin tubules were occluded completely immediately after and 7 days after ammonium hexafluorosilicate treatment. Some silica compounds are known to induce apatite formation, therefore, silica-calcium phosphate precipitate formed with ammonium hexafluorosilicate treatment may play important roles for durable occlusion of dentin tubules by inducing apatite precipitate from saliva. In addition, we evaluate whether or not ammonium hexafluorosilicate increase acid resistance of bovine enamel and dentin. The depth of demineralized tooth was measured with surface roughness analyzer. Diamine silver fluoride and ammonium hexafluorosilicate treatment showed greater acid resistance that of NaF or acidulated phosphate fluoride treatment. The deminaralized depth was reduced 24.1% and 23.9%, ammonium hexafluorosilicate and diamine silver fluoride treatment, respectively. It was concluded that ammonium hexafluorosilicate is useful for the treatment of dentin hypersensitivity and prevent of progress of dental caries since ammonium hexafluorosilicate treatment occluded open dentin tubules completely with silica-calcium phosphate precipitate and increased acid resistance of bovine tooth without changing the color of tooth.

二胺氟化银（Saforide）是临床用途，可防止龋齿的进展并脱敏性牙齿。不幸的是，由于银色沉淀，二胺氟化物的氟化物染成黑色。因此，二胺氟化物主要涂在落叶牙齿上。为了克服这一缺点，准备了六氟硅酸铵。这项研究的目的是评估六氟氨基硅酸盐处理后牙本质小管和牛牙齿耐酸的遮挡能力。六氟糖硅酸盐治疗后，在合成唾液中浸入7天后，使用扫描电子显微镜（SEM）观察到牙本质盘的表面。 SEM观察表明，在六氟氨基硅酸铵治疗后和7天后，完全闭塞开放式牙本质小管。已知一些二氧化硅化合物诱导磷灰石形成，因此，用六氟硅酸盐处理形成的二氧化硅 - 磷酸盐沉淀物可能会通过诱导唾液中的磷灰石沉淀物来耐用牙本质小管的持久闭塞。此外，我们评估六氟氨基硅铵是否会增加牛搪瓷和牙本质的酸性。用表面粗糙度分析仪测量脱矿质牙齿的深度。二氨基氟化物和六氟硅酸铵的治疗表现出比NAF或酸性磷酸氟化物处理更大的酸性耐药性。分别降低了24.1％和23.9％，分别降低了六氟硅酸铵和二氨基氟化物的氟化物治疗。得出的结论是，六氟氨基硅氨基酸铵可用于治疗牙本质超敏反应和防止龋齿的进展，因为六氟氨基硅酸铵治疗治疗甲基甲氟乙醇氨基酸铵与磷酸盐磷酸盐沉淀物，并增加牙齿颜色的酸性耐牙的酸性抗性。

项目成果

Comparison of the occluding ability of dentinal tubules with different morphology between calcium phosphate precipitation method and potassium oxalate treatment

• DOI: 10.4012/dmj.24.522
• 发表时间: 2005-12-01
• 期刊: DENTAL MATERIALS JOURNAL
• 影响因子: 2.5
• 作者: Suge, T;Kawasaki, A;Ebisu, S
• 通讯作者: Ebisu, S

Ammonium hexafluorosilicate increased acid resistance of bovine enamel and dentine

六氟硅酸铵提高牛牙釉质和牙本质的耐酸性

• 发表时间: 2005
• 期刊: Journal of Material Science : Materials in Medicine 16・5
• 作者: Ryoma Nakao;Hidenobu Senpuku;Haruo Watanabe;Tanaka T.;Inoue H;Morimoto Y;Ono K;Okabe S;Kito S;Kito S.;Morimoto Y.;Tanaka T.;Morimoto Y.;Tanaka T.;Kito S.;Tanaka T.;Takagi Y;Takagi Y;Takagi Y;市原 隆洋;岸川隆蔵;瀬戸浩行他;瀬戸浩行他;Kawashima N;Kawashima N;Kawashima N;川島伸之;Kawashima N;Kawashima N;Kawashima N;川島伸之;T.Suge et al.;T.Suge et al.;T.Suge et al.;A.Kawasaki et al.
• 通讯作者: A.Kawasaki et al.

A new treatment method for dentin hypersensitivity : application of ammonium hexafluorosilicate solution

治疗牙本质过敏的新方法：六氟硅酸铵溶液的应用

• 发表时间: 2006
• 期刊: Dental tribune, Asia Pacific edition 4・12
• 作者: Ohara N;Hayashi Y;S;Kim S-K;Matsunaga T;Yanagiguchi K;Ikeda T;吉羽邦彦;Y.Nomura;T.Suge et al.
• 通讯作者: T.Suge et al.

Effects of ammonium hexafluorosilicate on dentinal tubule occlusion for the treatment of dentin hypersensitivity

六氟硅酸铵对牙本质小管闭塞治疗牙本质过敏的影响

• 发表时间: 2006
• 期刊: American Journal of Dentistry (in press)
• 作者: Ryoma Nakao;Hidenobu Senpuku;Haruo Watanabe;Tanaka T.;Inoue H;Morimoto Y;Ono K;Okabe S;Kito S;Kito S.;Morimoto Y.;Tanaka T.;Morimoto Y.;Tanaka T.;Kito S.;Tanaka T.;Takagi Y;Takagi Y;Takagi Y;市原 隆洋;岸川隆蔵;瀬戸浩行他;瀬戸浩行他;Kawashima N;Kawashima N;Kawashima N;川島伸之;Kawashima N;Kawashima N;Kawashima N;川島伸之;T.Suge et al.
• 通讯作者: T.Suge et al.

Effiects of pre- or post-application of calcium chloride on occluding ability of potassium oxalate for the treatment of dentin hypersensitivity

氯化钙前后应用对草酸钾治疗牙本质过敏的封闭能力的影响

• 发表时间: 2005
• 期刊: American Journal of Dentistry 18・2
• 作者: Nomura Y;Teshima W;Kawahara T;Tanaka N;Ishibashi H;Okazaki M;Arizono K.;Yokota H;T.Suge et al.
• 通讯作者: T.Suge et al.