Development of treatment method for prevention of dental caries and dentin hypersensitivity with silica-fluoride compound

硅氟化合物预防龋齿和牙本质过敏的治疗方法的开发

• 批准号: 16591916
• 负责人: SUGE Toshiyuki
• 金额: $ 2.24万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591916/
• 关键词: ammonium hexafluorosilicate; diamine silver fluoride; fluoride; dentin hypersensitivity; dental caries; silica; calcium phosphate; dentin tubule; イヌ生活歯; 操作型電子顕微鏡; 人工唾液; 象牙質透過性; 象牙細管内液; フッ化カルシウム

Diamine silver fluoride (Saforide) is clinical use for prevent of progress of dental caries and desensitizing for hypersensitive tooth. Unfortunately, diamine silver fluoride stained tooth black due to silver precipitation. Therefore, diamine silver fluoride is mainly applied deciduous tooth. To overcome this drawback, ammonium hexafluorosilicate was prepared. The purpose of this study was to evaluate the occluding ability of dentin tubules and acid resistance of bovine tooth after ammonium hexafluorosilicate treatment. The surface of dentin disks was observed with scanning electron microscopy (SEM) at immediately after ammonium hexafluorosilicate treatment and 7 days after immersion in synthetic saliva. SEM observation showed that open dentin tubules were occluded completely immediately after and 7 days after ammonium hexafluorosilicate treatment. Some silica compounds are known to induce apatite formation, therefore, silica-calcium phosphate precipitate formed with ammonium hexafluorosilicate treatment may play important roles for durable occlusion of dentin tubules by inducing apatite precipitate from saliva. In addition, we evaluate whether or not ammonium hexafluorosilicate increase acid resistance of bovine enamel and dentin. The depth of demineralized tooth was measured with surface roughness analyzer. Diamine silver fluoride and ammonium hexafluorosilicate treatment showed greater acid resistance that of NaF or acidulated phosphate fluoride treatment. The deminaralized depth was reduced 24.1% and 23.9%, ammonium hexafluorosilicate and diamine silver fluoride treatment, respectively. It was concluded that ammonium hexafluorosilicate is useful for the treatment of dentin hypersensitivity and prevent of progress of dental caries since ammonium hexafluorosilicate treatment occluded open dentin tubules completely with silica-calcium phosphate precipitate and increased acid resistance of bovine tooth without changing the color of tooth.

二胺氟化银（Saforide）临床用于预防龋齿进展和过敏牙齿脱敏。不幸的是，二胺氟化银由于银沉淀而将牙齿染黑。因此，二胺氟化银主要应用于乳牙。为了克服这个缺点，制备了六氟硅酸铵。本研究的目的是评价六氟硅酸铵处理后牛牙牙本质小管的闭塞能力和耐酸性。在六氟硅酸铵处理后立即和在合成唾液中浸泡7天后用扫描电子显微镜（SEM）观察牙本质盘的表面。 SEM观察显示，六氟硅酸铵处理后即刻和7天后，开放的牙本质小管完全闭塞。已知一些二氧化硅化合物会诱导磷灰石形成，因此，用六氟硅酸铵处理形成的二氧化硅-磷酸钙沉淀可能通过诱导唾液中的磷灰石沉淀而对牙本质小管的持久闭塞发挥重要作用。此外，我们还评估了六氟硅酸铵是否可以提高牛牙釉质和牙本质的耐酸性。用表面粗糙度仪测量牙齿脱矿深度。二胺氟化银和六氟硅酸铵处理显示出比NaF或酸化磷酸盐氟化物处理更高的耐酸性。六氟硅酸铵和二胺氟化银处理的脱矿深度分别降低了24.1%和23.9%。结论是，六氟硅酸铵可用于治疗牙本质过敏和预防龋齿的进展，因为六氟硅酸铵治疗用二氧化硅-磷酸钙沉淀完全闭塞开放的牙本质小管，并增加牛牙齿的耐酸性而不改变牙齿的颜色。

项目成果

Comparison of the occluding ability of dentinal tubules with different morphology between calcium phosphate precipitation method and potassium oxalate treatment

• DOI: 10.4012/dmj.24.522
• 发表时间: 2005-12-01
• 期刊: DENTAL MATERIALS JOURNAL
• 影响因子: 2.5
• 作者: Suge, T;Kawasaki, A;Ebisu, S
• 通讯作者: Ebisu, S

Ammonium hexafluorosilicate increased acid resistance of bovine enamel and dentine

六氟硅酸铵提高牛牙釉质和牙本质的耐酸性

• 发表时间: 2005
• 期刊: Journal of Material Science : Materials in Medicine 16・5
• 作者: Ryoma Nakao;Hidenobu Senpuku;Haruo Watanabe;Tanaka T.;Inoue H;Morimoto Y;Ono K;Okabe S;Kito S;Kito S.;Morimoto Y.;Tanaka T.;Morimoto Y.;Tanaka T.;Kito S.;Tanaka T.;Takagi Y;Takagi Y;Takagi Y;市原 隆洋;岸川隆蔵;瀬戸浩行他;瀬戸浩行他;Kawashima N;Kawashima N;Kawashima N;川島伸之;Kawashima N;Kawashima N;Kawashima N;川島伸之;T.Suge et al.;T.Suge et al.;T.Suge et al.;A.Kawasaki et al.
• 通讯作者: A.Kawasaki et al.

A new treatment method for dentin hypersensitivity : application of ammonium hexafluorosilicate solution

治疗牙本质过敏的新方法：六氟硅酸铵溶液的应用

• 发表时间: 2006
• 期刊: Dental tribune, Asia Pacific edition 4・12
• 作者: Ohara N;Hayashi Y;S;Kim S-K;Matsunaga T;Yanagiguchi K;Ikeda T;吉羽邦彦;Y.Nomura;T.Suge et al.
• 通讯作者: T.Suge et al.

Effects of ammonium hexafluorosilicate on dentinal tubule occlusion for the treatment of dentin hypersensitivity

六氟硅酸铵对牙本质小管闭塞治疗牙本质过敏的影响

• 发表时间: 2006
• 期刊: American Journal of Dentistry (in press)
• 作者: Ryoma Nakao;Hidenobu Senpuku;Haruo Watanabe;Tanaka T.;Inoue H;Morimoto Y;Ono K;Okabe S;Kito S;Kito S.;Morimoto Y.;Tanaka T.;Morimoto Y.;Tanaka T.;Kito S.;Tanaka T.;Takagi Y;Takagi Y;Takagi Y;市原 隆洋;岸川隆蔵;瀬戸浩行他;瀬戸浩行他;Kawashima N;Kawashima N;Kawashima N;川島伸之;Kawashima N;Kawashima N;Kawashima N;川島伸之;T.Suge et al.
• 通讯作者: T.Suge et al.

Effiects of pre- or post-application of calcium chloride on occluding ability of potassium oxalate for the treatment of dentin hypersensitivity

氯化钙前后应用对草酸钾治疗牙本质过敏的封闭能力的影响

• 发表时间: 2005
• 期刊: American Journal of Dentistry 18・2
• 作者: Nomura Y;Teshima W;Kawahara T;Tanaka N;Ishibashi H;Okazaki M;Arizono K.;Yokota H;T.Suge et al.
• 通讯作者: T.Suge et al.